Adding a certain compound to certain chemical reactions, such as: 3137-60-8, 5-Amino-6-chloropyrimidin-4(1H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 3137-60-8, blongs to pyrimidines compound. Application In Synthesis of 5-Amino-6-chloropyrimidin-4(1H)-one
Step 1. 5-aminopyrimidin-4-olTo a degassed mixture of 5-amino-6-chloropyrimidin-4-ol (227 mg, 1.56 mmol, Matrix) and triethylamine (1.09 mL, 7.80 mmol) in ethanol (15.0 mL) was added 10% palladium on carbon (51 mg) and the mixture was shaken under 50 psi hydrogen for two h. The mixture was filtered and concentrated to give product. LCMS (M+H)+: 112.1.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3137-60-8, its application will become more common.
Reference:
Patent; Rodgers, James D.; Shepard, Stacey; Arvanitis, Argyrios G.; Wang, Haisheng; Storace, Louis; Folmer, Beverly; Shao, Lixin; Zhu, Wenyu; Glenn, Joseph; US2010/298334; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
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