Category: 31401-45-3

Shkurko, O. P. published the artcileNMR spectra of pyrimidines. Effect of substituents on the chemical shift of meta-protons in 2- and 4-substituted pyrimidines, Product Details of C6H9N3, the publication is Khimiya Geterotsiklicheskikh Soedinenii (1978), 673-7, database is CAplus.

NMR chem. shifts were recorded for H-4 in I (R = Me₂N, MeO, Me, Ph, H, halo, CO₂Me, MeSO₂, CN) and for H-2 and H-6 in II (same R), and correlation equations with F and R substituent constants were obtained. The inductive effect of R was weaker when R and the observed H were separated by a ring N.

Khimiya Geterotsiklicheskikh Soedinenii published new progress about 31401-45-3. 31401-45-3 belongs to pyrimidines, auxiliary class Pyrimidine,Amine, name is N,N-Dimethylpyrimidin-4-amine, and the molecular formula is C39H35N5O8, Product Details of C6H9N3.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Sun, Chang-Zheng published the artcileCharacterization of the doxorubicin-pluronic F68 conjugate micelles and their effect on doxorubicin resistant human erythroleukemic cancer cells, Recommanded Product: N,N-Dimethylpyrimidin-4-amine, the publication is Journal of Nanomedicine & Nanotechnology (2011), 2(5), 1000114, database is CAplus.

Doxorubicin-pluronic F68 conjugate (DOX-P) was synthesized and its structure was confirmed by FTIR and H-NMR spectra. Using human erythroleukemic cancer cells as model, DOX-P application in chemotherapy was further investigated. Differential scanning calorimetry anal. was applied to compare the fusion and crystallization characterization between pluronic F68 and DOX-P. Morphol. and size assessment were measured using a transmission electron microscopy (TEM) to confirm the capability of forming micelles of DOX-P. Tumor cell lines K562 and K562/AO2 were used to investigate the effect of DOX-P on tumor cell resistance. The Tm and Tc of DOX-P were lower than pluronic F68 resulted from the connection of DOX to pluronic F68. Morphol. images confirmed the existence of DOX-P micelles, with an average size of about 20 nm. Drug release profile showed that the DOX-P conjugate maintained a sustained DOX release. From cell experiment in vitro, DOX-P micelles could circumvent the DOX resistance of K562/AO2 cells. With advantages of EPR effect and reducing tumor resistance, DOX-P micelles might develop as new tumor targeted delivery system for chemotherapy.

Journal of Nanomedicine & Nanotechnology published new progress about 31401-45-3. 31401-45-3 belongs to pyrimidines, auxiliary class Pyrimidine,Amine, name is N,N-Dimethylpyrimidin-4-amine, and the molecular formula is C7H5I2NO3, Recommanded Product: N,N-Dimethylpyrimidin-4-amine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Yang, Qiang published the artcileDevelopment of a Scalable Process for the Insecticidal Candidate Tyclopyrazoflor. Part 2. Fit-for-Purpose Optimization of the Route to Tyclopyrazoflor Featuring [3 + 2] Cyclization of 3-Hydrazinopyridine·2HCl and Methyl Acrylate, Synthetic Route of 31401-45-3, the publication is Organic Process Research & Development (2019), 23(10), 2133-2141, database is CAplus.

Optimization of the route to the sap-feeding insecticidal candidate tyclopyrazoflor (I) featuring [3 + 2] cyclization of 3-hydrazinopyridine·2HCl and Me acrylate is described. The key impurities in the [3 + 2] cyclization were identified and successfully controlled after optimization. The hazards associated with oxidation of an intermediate pyrazolidin-3-one using the incompatible combination of potassium persulfate and N,N-dimethylformamide (DMF) were avoided by using potassium ferricyanide in the presence of potassium hydroxide in water. The two elimination impurities in the ethylation step to produce tyclopyrazoflor were successfully minimized using Et iodide in the presence of cesium carbonate in DMF at 0 °C. The overall yield for this seven-step synthesis of tyclopyrazoflor was improved from 10% to 41% after the optimization detailed herein.

Organic Process Research & Development published new progress about 31401-45-3. 31401-45-3 belongs to pyrimidines, auxiliary class Pyrimidine,Amine, name is N,N-Dimethylpyrimidin-4-amine, and the molecular formula is C9H7NO3, Synthetic Route of 31401-45-3.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Shkurko, O. P. published the artcileVibrational spectra of monosubstituted pyrimidines, Quality Control of 31401-45-3, the publication is Zhurnal Prikladnoi Spektroskopii (1975), 23(5), 860-5, database is CAplus.

The ir and Raman spectra of 2-, 4-, and 5-monosubstituted pyrimidine derivatives were measured at 400-1600 cm-1 and the characteristic frequencies were assigned. The Raman spectra of the 2-substituted pyrimidines were characterized with strong polarized bands at 1075-95 (low intensity ir) belonging to the in-plane deformation vibration of the CH pyrimidine bonds, a 990-1000 (medium intensity ir) of the breathing vibrations of the ring at 720-870 of substituent-sensitive vibrations and with a medium depolarized band at 630-655 cm-1 (medium or strong in ir). The ir spectra show a strong band at 800-830 cm-1 (low in the Raman spectra) of the out-of plane CH vibrations. The 5-substituted derivatives show in the Raman spectra intensive polarized bands at 1080-1125 (in plane CH deformation) and at 720-860 cm-1 (substituent-sensitive vibrations) and a medium band at 610-40 cm-1. The ir spectra show, in analogy with 1,3,5-trisubstituted benzene, strong bands at 860-900 and 710-730 cm-1. The Raman spectra of the 4-monosubstituted pyrimidines are characterized with strong polarized bands at 980-95 (“breathing” vibrations) and at 720-870 cm-1 both frequencies are of medium intensity in the ir. The bands at 1100 and 610-640 cm-1 observed at 2- and 5-substituted pyrimidines are absent. The ir spectra show intense bands of the out-of-plane CH deformation vibrations at 800-850 cm-1 which are of low intensity in the Raman spectrum.

Zhurnal Prikladnoi Spektroskopii published new progress about 31401-45-3. 31401-45-3 belongs to pyrimidines, auxiliary class Pyrimidine,Amine, name is N,N-Dimethylpyrimidin-4-amine, and the molecular formula is C14H17FN4O3, Quality Control of 31401-45-3.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia

Herbich, Jerzy published the artcileModification of the intramolecular electron transfer by hydrogen bonding: 4-(dialkylamino)pyrimidines, Formula: C6H9N3, the publication is Journal of Luminescence (1992), 54(3), 165-75, database is CAplus.

The dual fluorescence (a and b) and the picosecond kinetics of the twisted intramol. charge transfer (TICT) state formation in 4-(dialkylamino)pyrimidines were studied in polar solvents. In nitriles as solvents, 2 emitting states of 4-(N,N-dimethylamino)pyrimidine or 4-(N,N-diethylamino)pyrimidine reached equilibrium within 20 ps. In alcs. the TICT emission a is attributed to the species hydrogen-bonded at the ring atom N1. The decay of the short wave fluorescence b is clearly multi- or non-exponential; it is assigned to several other complexes, some of which decay fast, not being simply kinetically coupled with the emitting form a. The nature of the fast deactivation channel appearing in alcs. as solvents is discussed taking into account the Mataga-Kakitani discrimination of the Marcus inverted regions for the charge recombination and charge shift electron transfer.

Journal of Luminescence published new progress about 31401-45-3. 31401-45-3 belongs to pyrimidines, auxiliary class Pyrimidine,Amine, name is N,N-Dimethylpyrimidin-4-amine, and the molecular formula is C6H9N3, Formula: C6H9N3.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia