Category: 31462-58-5

Reference of 31462-58-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.31462-58-5, name is 5-Iodopyrimidine, molecular formula is C4H3IN2, molecular weight is 205.9845, as common compound, the synthetic route is as follows.

General procedure: In a typical experiment, 0.75 mg (0.03 mol%) of 3 was added into a mixture of aryl halide (1.0 mmol), olefin (2 mmol), Et3N (3 mmol) in DMF (2 mL), and the reaction mixture was stirred at 130 C. The formation of coupling product was monitored byTLC/GC analyses. After disappeared of the aryl halide (checking by TLC/GC), the reaction mixture was cold at room temperature and diluted with water and ethyl acetate and the solid Pd(II) complex 3 was separated by filtration. The cross-coupling product was extracted from the aqueous layer with ethyl acetate (3 x 5 mL), dried over MgSO4 and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (ethyl acetate/hexane) to give the corresponding cross-coupling product.

Statistics shows that 31462-58-5 is playing an increasingly important role. we look forward to future research findings about 5-Iodopyrimidine.

Reference:
Article; Sarkar, Shaheen M.; Rahman, Md. Lutfor; Chong, Kwok Feng; Yusoff, Mashitah Mohd; Journal of Catalysis; vol. 350; (2017); p. 103 – 110;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 31462-58-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.31462-58-5, name is 5-Iodopyrimidine, molecular formula is C4H3IN2, molecular weight is 205.9845, as common compound, the synthetic route is as follows.

General procedure: A mixture of parthenolide (1.0mmol) and an appropriate aromatic iodide (1.1mmol) was refluxed at 80C using palladium (II) ferrocene (0.01mmol) and di-isopropylethyl-amine (3.0mmol) in toluene (0.1ml) under air for 18-24h. The reaction mixture was then allowed to cool to room temperature, water (8ml) added, and the resultant mixture was extracted with ethyl acetate (10ml×3). The separated organics were dried over Na2SO4, filtered and the filtrate concentrated under reduced pressure. The obtained crude residue was purified by silica flash chromatography (9:1 to 4:1, hexanes/EtOAc) to afford the corresponding aryl substituted parthenolide as a solid (40-50mg) in 70-80% yield.

Statistics shows that 31462-58-5 is playing an increasingly important role. we look forward to future research findings about 5-Iodopyrimidine.

Reference:
Article; Penthala, Narsimha R.; Bommagani, Shobanbabu; Janganati, Venumadhav; Macnicol, Kenzie B.; Cragle, Chad E.; Madadi, Nikhil R.; Hardy, Linda L.; Macnicol, Angus M.; Crooks, Peter A.; European Journal of Medicinal Chemistry; vol. 85; (2014); p. 517 – 525;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 31462-58-5, Adding some certain compound to certain chemical reactions, such as: 31462-58-5, name is 5-Iodopyrimidine,molecular formula is C4H3IN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 31462-58-5.

General procedure: In a typical experiment, 0.75 mg (0.03 mol%) of 3 was added into a mixture of aryl halide (1.0 mmol), olefin (2 mmol), Et3N (3 mmol) in DMF (2 mL), and the reaction mixture was stirred at 130 C. The formation of coupling product was monitored byTLC/GC analyses. After disappeared of the aryl halide (checking by TLC/GC), the reaction mixture was cold at room temperature and diluted with water and ethyl acetate and the solid Pd(II) complex 3 was separated by filtration. The cross-coupling product was extracted from the aqueous layer with ethyl acetate (3 x 5 mL), dried over MgSO4 and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (ethyl acetate/hexane) to give the corresponding cross-coupling product.

According to the analysis of related databases, 31462-58-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Sarkar, Shaheen M.; Rahman, Md. Lutfor; Chong, Kwok Feng; Yusoff, Mashitah Mohd; Journal of Catalysis; vol. 350; (2017); p. 103 – 110;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 31462-58-5, name is 5-Iodopyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 5-Iodopyrimidine

General procedure: To 3-{2-[(tert-butyldimethylsilyl)oxy]ethyl}-13-{4-[5-chloro-2-(lH-l,2,3-triazol- 1 -yl)phenyl]-6-oxo- 1 ,2,3,6-tetrahydropyridin- 1 -yl} -9-methyl-3,4,7, 15-tetraazatricyclo [12.3.1.02’6]octadeca-l(18),2(6),4,14,16-pentaen-8-one was added MeOH (0.7 ml) and cone. HC1 (0.05 ml, 0.60 mmol) and the reaction was stirred for 10 min. The crude product was purified by reverse phase preparative HPLC to yield 13-{4-[5-chloro-2-(lH- 1,2,3-triazol- l-yl)phenyl]-6-oxo- 1,2,3, 6-tetrahydropyridin-l-yl}-3-(2-hydroxyethyl)-9- methyl-3 ,4,7, 15 -tetraazatricyclo[ 12.3.1.02’6] octadeca- 1 ( 18),2(6),4, 14, 16-pentaen-8-one as a white solid (6 mg, 8.22 muiotaetaomicron, 22.2% yield). NMR (500MHz, CD3OD) delta 8.76 – 8.70 (m, 1H), 8.34 – 8.30 (m, 1H), 7.93 – 7.88 (m, 1H), 7.84 – 7.78 (m, 1H), 7.68 – 7.62 (m, 3H), 7.60 (s, 3H), 5.89 – 5.81 (m, 1H), 5.59 – 5.50 (m, 1H), 4.44 – 4.38 (m, 2H), 4.05 – 3.97 (m, 3H), 3.51 – 3.45 (m, 2H), 2.61 – 2.51 (m, 1H), 2.23 – 2.09 (m, 3H), 1.99 – 1.81 (m, 2H), 1.65 – 1.53 (m, 1H), 1.39 – 1.28 (m, 2H), 1.19 – 1.12 (m, 2H), 1.12 – 1.08 (m, 3H). MS(ESI) m/z: 587.5 (M+H)+. Analytical HPLC (Method A): RT = 5.33 min, purity = 96%; Factor XIa Ki = 5.5 nM, Plasma Kallikrein Ki = 140 nM.(9R, 135)- 13- {4- [3 -Chloro-2-fluoro-6-(trifluoromethyl)phenyl]-6-oxo- 1,2,3,6- tetrahydropyridin- 1 -yl} -9-methyl-4-(pyrimidin-5-yl)-3 ,4,7, 15 -tetraazatricyclo[ 12.3.1.026] octadeca- 1(1 8),2,5,14,1 6-pentaen-8-one trifluoroacetate (7.5 mg, 9.85 imol, 18% yield)was prepared according to the procedures described in Example 11 by substituting (2-bromoethoxy)Qert-butyl)dimethylsilane with 5-iodopyrimidine. ?H NMR (500MHz,DMSO-d6) oe 9.58 (s, 1H), 9.39 (s, 2H), 9.19 (s, 1H), 8.80 (s, 1H), 8.68 (d, J=4.9 Hz, 1H),7.85 (t, J=7.8 Hz, 1H), 7.76 (s, 1H), 7.70 (d, J=8.5 Hz, 1H), 7.60 (d, J=4.3 Hz, 1H), 7.266.97 (m, 1H), 5.92 (s, 1H), 5.71 (d, J=8.8 Hz, 1H), 3.97 (br. s., 1H), 3.67 (br. s., 1H), 3.443.36 (m, 1H), 2.73 (br. s., 1H), 2.19 (br. s., 1H), 2.06 (br. s., 1H), 1.76 (br. s., 1H), 1.56(br. s., 1H), 1.34 (br. s., 1H), 0.97 (d, J=6.7 Hz, 3H), 0.69 (br. s., 1H). MS(ESI) m/z:640.1 [M+H]. Analytical HPLC (Method B): RT = 1.84 mm, purity = 99.0%; Factor XIaKi = 5.4 nM, Plasma Kallikrein Ki = 13 nM.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 31462-58-5, 5-Iodopyrimidine.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; DILGER, Andrew, K.; CORTE, James, R.; DE LUCCA, Indawati; FANG, Tianan; YANG, Wu; WANG, Yufeng; PABBISETTY, Kumar Balashanmuga; EWING, William, R.; ZHU, Yeheng; WEXLER, Ruth, R.; PINTO, Donald, J.P.; ORWAT, Michael, J.; SMITH II, Leon, M.; WO2015/116882; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 31462-58-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.31462-58-5, name is 5-Iodopyrimidine, molecular formula is C4H3IN2, molecular weight is 205.9845, as common compound, the synthetic route is as follows.

General procedure: To a round-bottom flask, aryl electrophile (1.0mmol), Pdnanocatalyst (1.5 mol%), Cs2CO3(1.5 mmol), PhB(OH)2(1.3 mmol), and EtOH (3.0 mL) were added, stirred andheated at 80C. The progress of the reaction was checked using TLC. After the completion of the reaction, the mixturewas cooled down and the catalyst was isolated usingan external magnet. The solvent was evaporated and furtherpurification was achieved using column chromatography onsilica gel to deliver the desired biphenyl derivatives in highyields.

The chemical industry reduces the impact on the environment during synthesis 31462-58-5, I believe this compound will play a more active role in future production and life.

Reference:
Article; Khalili, Dariush; Banazadeh, Ali Reza; Etemadi-Davan, Elham; Catalysis Letters; vol. 147; 10; (2017); p. 2674 – 2687;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 31462-58-5, name is 5-Iodopyrimidine. A new synthetic method of this compound is introduced below., Formula: C4H3IN2

General procedure: Ir[dF(CF3)ppy]2(dtbpy))PF6(5.6 mg, 4.99 mumol) was added to a stirred solution of aryl iodide (1.00 mmol), iminodimethyl-lambda6-sulfanone (102 mg, 1.10 mmol), 4,4′-di-tert-butyl-2,2′-bipyridine (20 mg, 0.07 mmol), TEA (0.279 mL, 2.00 mmol) and NiCl2(glyme) (11 mg, 0.05 mmol) in acetonitrile (5.6 mL). The resulting mixture was irradiated with a blue LED (450 nm, Penn Optical Photoreactor m1) and stirred at 29 C for 16 hours. The reaction mixture was quenched with saturated aqueous NaHCO3(2 mL) and extracted with EtOAc. The organic layer was dried over MgSO4, filtered, and concentrated under reduced pressure.The resulting residue was purified by flash silica chromatography to afford the corresponding products.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 31462-58-5, 5-Iodopyrimidine.

Reference:
Article; Hande, Sudhir; Mfuh, Adelphe; Throner, Scott; Wu, Ye; Ye, Qing; Zheng, XiaoLan; Tetrahedron Letters; vol. 60; 41; (2019);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 31462-58-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 31462-58-5, name is 5-Iodopyrimidine, molecular formula is C4H3IN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Aryl halide (1 mmol) and n-butyl acrylate (1.5 mmol) were added to a flask containing the aminoclay picolinic acid nano-Pd(0) complex catalyst (0.5 mg of the catalyst, containing 1.2 x 10-3 mmol of palladium) and n-Pr3N (1.5 mmol, 0.29 mL) in the absence of solvent. The mixture was stirred at 120 C in the air. After completion of the reaction (monitored by TLC), the reaction mixture was diluted with diethyl ether (5 mL) and the catalyst was separated by centrifuging. The diluted reaction mixture was extracted with water (3 9 15 mL). The ethereal layer was dried over anhydrous MgSO4 and condensed under the reduced pressure to provide the crude product. The crude product was purified by column chromatography using ethyl acetate and hexane mixtures as eluent to obtain the pure Heck product.

According to the analysis of related databases, 31462-58-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Fahimi, Nafiseh; Sardarian, Ali Reza; Research on Chemical Intermediates; vol. 43; 8; (2017); p. 4923 – 4941;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 31462-58-5, name is 5-Iodopyrimidine, the common compound, a new synthetic route is introduced below. SDS of cas: 31462-58-5

General procedure: Aryl iodide or bromides (1 mmol), ArOH (1 mmol), CuI(20 mol%), and dimethyl di (2-pyridyl)silane (20 mol%) were placed in a small round-bottom flask. DMF (3 mL) and K2CO3(276 mg, 2 mmol) were then added together. The mixture was stirred for 24 h at 100C in nitrogen atmosphere. The reaction mixture was cooled to room temperature. Ethyl acetate(10 mL) and H2O (1 mL) were added and the mixture was stirred. The organic layer was separated and the aqueous layer was extracted twice more with ethyl acetate (10 mL). Combined organic layer was dried overNa2SO4 and filtered. The filtrate was concentrated and the resulting residue was purified by silica gelchromatography and afforded the desired products.

The synthetic route of 31462-58-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhang, Baohua; Shi, Lanxiang; Guo, Ruixia; Liu, Sijie; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 191; 6; (2016); p. 930 – 932;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 31462-58-5, name is 5-Iodopyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 31462-58-5

A mixture of Example 5d (0.300 g, 0.618 mmol), 5-iodopynmidine (0382 g, 1.353 mmo-i cesium carb onate (0.403 g, 1 36 mmol), dicyclohexyli^^’^-triisopropyl-tl,’- bipher^2-yl)phosphine (XPhos)(0.147 g, 0.309 mmo and palladium (Pi) acetate (0035 g, 0.154 mmol) in toluene ( 12 mL) and ter i-tutanol (3 mL) under argonwas heated in a sealed tube in a rraciowave reactor at 160 * C for 1 hour. The reaction mixture was cooled to amb ient tenperature and filtered tluDugh filter paper. The resulting filtrate was concentrated to near dryness and mixed with ethanol ( 10 mL), dioxane (20 mL j, and excess 5N s odium hydroxide solution ( 10 niL). The reaction mixture: was stirred at ant ient temperature for 1 hour and then concentrated to 5 niL and partitioned between s aturated anmionium chloride aqueous solution and ethyl acetate . The aqueous phase was extracted once more with ethyl acetate. The combined organic layers were was hed with s aturated aqueous sodium cliloride, dried over ar-hydro s mag esi m sulfate, filtered, and concentrated. The res idue was purified by flash column chromatograp ^ on s ilica gel elating with 5 % methanol in dichlorortrethane to afford the title conpou d (0.066 g, 0.1 1 mmol, 26 % yield) .

With the rapid development of chemical substances, we look forward to future research findings about 31462-58-5.

Reference:
Patent; ABBVIE INC.; ABBVIE PHARMACEUTICAL TRADING (SHANGHAI) CO., LTD.; FIDANZE, Steven D.; LIU, Dachun; MANTEI, Robert A.; MCDANIEL, Keith F.; PRATT, John; SHEPPARD, George S.; WANG, Le; BOGDAN, Andrew; HOLMS, James H.; DIETRICH, Justin D.; MARJANOVIC, Jasmina; HASVOLD, Lisa A.; DAI, Yujia; WO2014/139324; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 31462-58-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 31462-58-5, name is 5-Iodopyrimidine, molecular formula is C4H3IN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a round-bottom flask, aryl electrophile (1.0mmol), Pdnanocatalyst (1.5 mol%), Cs2CO3(1.5 mmol), PhB(OH)2(1.3 mmol), and EtOH (3.0 mL) were added, stirred andheated at 80C. The progress of the reaction was checked using TLC. After the completion of the reaction, the mixturewas cooled down and the catalyst was isolated usingan external magnet. The solvent was evaporated and furtherpurification was achieved using column chromatography onsilica gel to deliver the desired biphenyl derivatives in highyields.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 31462-58-5, 5-Iodopyrimidine.

Reference:
Article; Khalili, Dariush; Banazadeh, Ali Reza; Etemadi-Davan, Elham; Catalysis Letters; vol. 147; 10; (2017); p. 2674 – 2687;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia