With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.319442-19-8, name is Ethyl 4-oxo-3,4-dihydrothieno[3,2-d]pyrimidine-2-carboxylate, molecular formula is C9H8N2O3S, molecular weight is 224.24, as common compound, the synthetic route is as follows.SDS of cas: 319442-19-8
General procedure: A mixture of compound 6a (240 mg, 4.00 mmol) and 3-methoxybenzylamine (138 mg, 1.00 mmol) in DMF (3 mL) washeated at 90 C for 5 h. The reaction mixture was concentratedunder reduced pressure. The residue was diluted with ethyl acetate,washed with brine, dried over anhydrous Na2SO4 and concentratedunder reduced pressure. The crude product was purified bypreparative HPLC and crystallized from ethanol-diethyl ether togive 7a as a beige powder (88.5 mg, 42%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,319442-19-8, Ethyl 4-oxo-3,4-dihydrothieno[3,2-d]pyrimidine-2-carboxylate, and friends who are interested can also refer to it.
Reference:
Article; Nara, Hiroshi; Sato, Kenjiro; Naito, Takako; Mototani, Hideyuki; Oki, Hideyuki; Yamamoto, Yoshio; Kuno, Haruhiko; Santou, Takashi; Kanzaki, Naoyuki; Terauchi, Jun; Uchikawa, Osamu; Kori, Masakuni; Bioorganic and Medicinal Chemistry; vol. 22; 19; (2014); p. 5487 – 5505;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia