Category: 3270-97-1

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3270-97-1, name is 2,4-Diamino-6-methoxypyrimidine, the common compound, a new synthetic route is introduced below. Quality Control of 2,4-Diamino-6-methoxypyrimidine

EXAMPLE 73 2-Amino-4-methoxypyrido[2,3-d]pyrimidine A quantity of 4.94 gm of 2,4-diamino-6-methoxypyrimidine is heated to boiling in 120 ml of glacial acetic acid and, after the addition of 6.4 ml of 1,1,3,3-tetramethoxypropane, left for a further 45 minutes at boiling temperature. Then, the glacial acetic acid is distilled off and evaporated several times with water, and the residue is taken up in 400 ml of water. After the addition of 5 gm of sodium bicarbonate, the residue is removed by suction filtration and discarded. The filtrate is extracted several times with chloroform, and the combined extracts are washed with sodium bicarbonate solution and then dried over sodium sulfate. The residue remaining after evaporation is purified on silica gel with chloroform and a chloroform/methanol mixture and then recrystallized from water. Yield: 2.5 gm (40.5%) of 2-amino-4-methoxy-pyrido[2,3-d]pyrimidine in the form of crystals, m.p.: 178-180 C. Elementary analysis Calc.: C 54.54 H 4.58 N 31.80. Found: 54.42 4.56 31.77.

The synthetic route of 3270-97-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Celamerck GmbH & Co. KG.; US4826528; (1989); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 3270-97-1, Adding some certain compound to certain chemical reactions, such as: 3270-97-1, name is 2,4-Diamino-6-methoxypyrimidine,molecular formula is C5H8N4O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3270-97-1.

EXAMPLE 3 Preparation of diethyl 6-methoxypyrimidine-2,4-dioxamate monohydrate: 2,4-Diamino-6-methoxypyrimidine (3.78 g) is dissolved in anhydrous pyridine (20 ml) and thereto is added dropwise ethyloxalyl chloride (9.83 g) under ice cooling, and the mixture is stirred at room temperature for one hour. To the reaction mixture is added water, and the mixture is extracted with ethyl acetate. The organic layer is washed with water and saturated aqueous sodium chloride, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting solid is recrystallized from water-ethanol to give title compound (8.8 g) having the following physical properties. m.p. 132-134 C. IR (KBr) nu: 3625, 3530, 3420, 3010, 1740, 1610, 1530, 1475, 1400, 1305, 1210, 1170, 1100, 1050, 1015, 970, 840 cm-1. NMR (DMSO-d6) delta: 11.30 (1H, s), 10.60 (1H, s), 7.03 (1H, s), 4.29 (4H, q), 3,87 (3H, s), 1.30 (3H, t), 1.25 (3H, t). Elementary analysis: Calcd.: C, 43.58; H, 5.06; N, 15.64 (%). Found: C, 43.75; H, 4.85; N, 15.89 (%).

According to the analysis of related databases, 3270-97-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Toyo Boseki Kabushiki Kaisha; US4729995; (1988); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 3270-97-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 3270-97-1 as follows.

(Essigsaeure=acetic acid) To a stirred solution of 7.0 g (0.05 mol) 6-methoxy-2,4-diaminopyrimidine in 100 ml acetic acid (10% conc. in water) at 50-60 C. was added dropwise over a period of 30 min a solution of 4.55 g (0.07 mol) sodium nitrite in 20 ml water. The solution was stirred at this temperature for a further 30 min and then stirred at room temperature overnight. The filtrate was filtered off with suction, washed with water and dried. 5-Nitroso-2,4-diamino-6-methoxypyrimidine (7.80 g, 92%) was obtained as a violet solid. m.pt.: 250 C. (dec.) 1H-NMR (300 MHz, d6-DMSO): delta=4.04 (s, 3 H, 6-OMe), 7.79 (s,1H, NH2), 7.85 (s,1H, NH2), 8.01 (s,1H, NH2), 10.10 (s, 1H, NH2). 13C-NMR (125 MHz, d6-DMSO): delta=54.5 (6-OMe), 140.0 (5-C), 151.2 (2-C), 163.8 (4-C), 171.4 (6-C).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3270-97-1, its application will become more common.

Reference:
Patent; Gebert, Antje; Giesa, Helmut; Koenen, Annika; US2015/209257; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3270-97-1, name is 2,4-Diamino-6-methoxypyrimidine, molecular formula is C5H8N4O, molecular weight is 140.14, as common compound, the synthetic route is as follows.Computed Properties of C5H8N4O

2,4-Diamino-6-chloropyrimidine (17.34 g: 120 mmol) and sodium methoxide (38.9 g) were sequentially added to t-butanol (60 mL) and N-ethylpyrrolidone (30 mL) under a nitrogen gas flow, followed by stirring with heating at 80 C. for 2 hours. The reaction solution was cooled to 60 C., and methyl benzoate (38.9 g: 288 mol) was dropwise added thereto, followed by stirring with heating at 60 C. for 2 hours. The reaction solution was added to a liquid mixture of iced water (130 mL) and concentrated hydrochloric acid (51 mL), followed by heating to 50 C. to completely dissolve the solid component. The organic layer was separated, and methanol (100 mL) and water (100 mL) were added thereto, followed by stirring under ice cooling for 1 hour. The precipitated product was collected by filtration, and the resulting crystals were washed with a poured methanol/water solvent mixture and then water. After ventilation drying at 50 C. for 13 hours, 38 g (yield: 85%) of compound (1-9) was yielded.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3270-97-1, 2,4-Diamino-6-methoxypyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; FUJIFILM Corporation; YAMAMOTO, Aiko; TANAKA, Satoshi; NIORI, Teruki; NAGURA, Masato; NORO, Masaki; YOSHIDA, Aiko; FUKAGAWA, Nobutaka; KUWAYAMA, Yasukazu; (89 pag.)US2016/159750; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia