Category: 32779-36-5

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 32779-36-5, name is 5-Bromo-2-chloropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C4H2BrClN2

[000295] Synthesis of 5 -bromo-2-iodopyrimidine (361): To a stirred solution of 5 -bromo-2- chloropyrimidine 360 (1 g, 5.16 mmol) in CH2C12 (10 mL) was added hydrogen iodide (5 mL, 57% aqueous solution) at -10 C; warmed to 0 C and stirred for 5 h. The reaction was monitored by TLC; after completion of the reaction, the reaction mixture was quenched with solid K2C03 (2 g), diluted with water (100 mL) and extracted with CH2C12 (2 x 100 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo to obtain crude compound 361 (1.4 g, 94%) as yellow solid. TLC: 10% EtOAc/ hexanes (R 0.7); 1H-NMR (DMSO-d6, 400 MHz): oe 8.55 (s, 2H).

With the rapid development of chemical substances, we look forward to future research findings about 32779-36-5.

Reference:
Patent; INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION; ASSEMBLY BIOSCIENCES, INC.; TURNER, William W.; ARNOLD, Lee Daniel; MAAG, Hans; ZLOTNICK, Adam; WO2015/138895; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 32779-36-5, name is 5-Bromo-2-chloropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 5-Bromo-2-chloropyrimidine

The subtitle compound was prepared following a method by Takahashi et al., Chem.Pharm. Bull, 1958, 6, 334-337. To a solution of 5-bromo-2-chloropyrimidine (1.0 g, 5.2mmol) in EtOH was added sodium methanethiolate (0.36 g, 5.2 mmol) at roomtemperature and the reaction mixture was stirred overnight. The mixture was partitionedbetween EtOAc (15 mL) and water (10 mL). The aqueous layer was extracted twice withEtOAc and washed with brine. The combined organic layers were dried and concentratedto give the subtitle compound as a white solid (1.1 g).^-NMR (CD3OD): 5 8.66 (2H, s); 2.54 (3H, s).APCI-MS m/z: 204/206 1:1 [MH+].

With the rapid development of chemical substances, we look forward to future research findings about 32779-36-5.

Reference:
Patent; ASTRAZENECA AB; WO2006/4532; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 32779-36-5, name is 5-Bromo-2-chloropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 5-Bromo-2-chloropyrimidine

The subtitle compound was prepared following a method by Takahashi et al., Chem.Pharm. Bull, 1958, 6, 334-337. To a solution of 5-bromo-2-chloropyrimidine (1.0 g, 5.2mmol) in EtOH was added sodium methanethiolate (0.36 g, 5.2 mmol) at roomtemperature and the reaction mixture was stirred overnight. The mixture was partitionedbetween EtOAc (15 mL) and water (10 mL). The aqueous layer was extracted twice withEtOAc and washed with brine. The combined organic layers were dried and concentratedto give the subtitle compound as a white solid (1.1 g).^-NMR (CD3OD): 5 8.66 (2H, s); 2.54 (3H, s).APCI-MS m/z: 204/206 1:1 [MH+].

With the rapid development of chemical substances, we look forward to future research findings about 32779-36-5.

Reference:
Patent; ASTRAZENECA AB; WO2006/4532; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 32779-36-5, name is 5-Bromo-2-chloropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C4H2BrClN2

To a stirred solution of 1-boc-piperazine (6.0 g, 31.5 mmol) in DMF (50 mL), triethyl amine (7 mL, 46.00 mmol) and 5-bromo-2-chloropyrimidine (6.3 g, 37.00 mmol) were added and the reaction mixture was stirred at 90 C for 8 h. The reaction mixture was concentrated under reduced pressure. Water (50 mL) was added and the desired product was extracted with DCM (150 mL). The organic layer was dried over Na2SO4 and concentrated under reduced pressure. The crude product was purified by flash chromatography (10% EtOAc in pet ether) to afford the title compound. Yield: 76% (7 g, white). 1H NMR (400 MHz, DMSO-d6): delta 8.46 (s, 2H), 3.68-3.67 (m, 4H), 3.39-3,37 (m, 4H), 1.40 (s, 9H). LCMS: (Method A) 289.0 (M+H), Rt. 5.19 min, 99.05% (Max).

With the rapid development of chemical substances, we look forward to future research findings about 32779-36-5.

Reference:
Patent; ASCENEURON SA; QUATTROPANI, Anna; KULKARNI, Santosh S.; GIRI, Awadut Gajendra; (243 pag.)WO2016/30443; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 32779-36-5, Adding some certain compound to certain chemical reactions, such as: 32779-36-5, name is 5-Bromo-2-chloropyrimidine,molecular formula is C4H2BrClN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 32779-36-5.

Step 1: tent-Butyl 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylate Into a 200 mL pressure flask equipped with a magnetic stir bar was added tert-butyl piperazine-1-carboxylate (4.8 g, 25.8 mmol), 5-bromo-2-chloropyrimidine (5.0 g, 25.8 mmol) and 2-propanol (50 mL). DIPEA (5.0 mL, 28.4 mmol) was added, the vial was sealed and the reaction mixture heated to 120 C. for 1 h. The cooled reaction mixture was poured into a 250 mL separatory funnel containing water (125 mL) and extracted with EtOAc (3*75 mL). The combined organic layers were washed with brine, dried over MgSO4, filtered and concentrated. Recrystallization from EtOAc (about 40 mL) and hexanes (about 150 mL) at -78 C. afforded crystals which were collected by filtration through filter paper on a Hirsch funnel under vacuum.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 32779-36-5, 5-Bromo-2-chloropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Isabel, Elise; Lachance, Nicolas; Leclerc, Jean-Philippe; Leger, Serge; Oballa, Renata M.; Powell, David; Ramtohul, Yeeman K.; Roy, Patrick; Tranmer, Geoffrey K.; Aspiotis, Renee; Li, Lianhai; Martins, Evelyn; US2011/301143; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 32779-36-5, Adding some certain compound to certain chemical reactions, such as: 32779-36-5, name is 5-Bromo-2-chloropyrimidine,molecular formula is C4H2BrClN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 32779-36-5.

To a mixture of benzyl alcohol (0.123 g, 1.14 mmol) and tetrahedrofuran (12.0 mL) was added sodium hydride (60 percent oil suspension, 0.050 g, 1.2 mmol) portionwise. After 10 min, 5-bromo-2-chloropyrimidine (0.200 g, 1.034 mmol) was added, and the mixture was stirred at room temperature overnight. The mixture was concentrated under reduced pressure. The residue was partitionated between ethyl acetate and water. The separated organic phase was washed with brine, dried over sodium sulfate, filtered and concentrated under reduced pressure to give 2- benzyloxy-5-bromopyrimidine (0.269 g, 98 percent) as a white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 32779-36-5, 5-Bromo-2-chloropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BAYER HEALTHCARE AG; WO2004/69805; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 32779-36-5, 5-Bromo-2-chloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C4H2BrClN2, blongs to pyrimidines compound. COA of Formula: C4H2BrClN2

5-Bromo-2-phenoxypyrimidine (intermediate AU) A mixture of 5-bromo-2-chloropyrimidine (5.00 g, 0.0259 mol), phenol (3.16 g, 0.0336 mol), dibenzo-18-crown-6 (0.47 g, 0.0013mol) and ground potassium hydroxide (3.51 g, 0.0626 mol) in toluene (75 ml) was heated at reflux for 5 hours with azeotropic removal of water. The mixture was allowed to cool to ambient temperature and the solvent was removed under reduced pressure. The residue was partitioned between water and chloroform. The layers were separated and the aqueous phase was extracted with chloroform three times. The combined organic layers were dried over magnesium sulfate, filtered and evaporated. The residue was purified by flash column chromatography on silica using n-heptane/ethyl acetate (98:2) as an eluent to give 5-bromo-2-phenoxy-pyrimidine as a white solid (3.55 g, 0.0141 mol): 1H NMR (DMSO-d6, 400 MHz) 8.80 (s, 2H), 7.45 (t, 2H), 7.27 (t, 1H), 7.22 (d 2H); TLC (n-heptane/ethyl acetate=95:5) Rf 0.20

The synthetic route of 32779-36-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Abbott Laboratories; US2002/156081; (2002); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 32779-36-5, 5-Bromo-2-chloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyrimidines, blongs to pyrimidines compound. category: pyrimidines

Example III-5 Morpholine (1.44 g, 16.5 mmol) is initially charged in acetonitrile (70 ml). Potassium carbonate (2.30 g, 16.5 mmol) is added, and the reaction mixture is stirred at room temperature for another hour. 5-Bromo-2-chloropyrimidine (2.90 g, 15.0 mmol) is added, and the reaction mixture is stirred at reflux for another 16 hours. After cooling, the reaction mixture is stirred into water (100 ml) and then extracted with ethyl acetate (2*50 ml). The organic phase is dried over sodium sulphate, filtered and concentrated. This gives 2.95 g (81% of theory) of 4-(5-bromo-2-pyrimidinyl)morpholine. HPLC: log P (pH 2.3)=2.15 (purity: 92%) m.p. 90 C.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,32779-36-5, 5-Bromo-2-chloropyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Plant, Andrew; Seitz, Thomas; Jansen, Johannes Rudolf; Erdelen, Christoph; Turberg, Andreas; Hansen, Olaf; US2004/82586; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 32779-36-5, 5-Bromo-2-chloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C4H2BrClN2, blongs to pyrimidines compound. Computed Properties of C4H2BrClN2

To a solution of THF (2000.0 ml) and sodium hydride (17.0 gm, 0.708 mol), was added A/-5-(4-bromophenyl)-6-(-2-hydroxyethoxy)-4-pyrimidinyl-//- propylsulfamide (100.0 gm, 0.23 mol) at 25-30°C. Stirred the content for 30 min at 25-30° C. DMF (400.0 ml) and 5-bromo-2-chloro-pyrimidine (65.0 gm; 0.033 mol) was added to the reaction mass at 25-30° C. Stirred and heated reaction mass to 60-65°C and maintain the reaction mass at 60-65° C for 2-4 hr. After completion of reaction monitored by HPLC, cooled the reaction mass to 25-30° C and 5percent w/v citric acid solution (2500.0 ml) was added. The compound was extracted twice with ethyl acetate (1500.0 ml x 2), followed by organic layer was washed with 10percent w/v brine solution (1500.0 ml). Ethyl acetate layer was concentrated at 55-60°C under reduced pressure to produce A/-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy] ethoxy]-4-pyrimidinyl]-/V-propylsulfamide as a crude residue. Obtained residue was dissolved at 65-70°C in methanol (2400.0 ml), stirred and maintained for 30 min. The resulting solution was gradually cooled to room temperature then cooled to 0-5°C and maintained reaction mass at 0-5°C for 45-60 min. Obtained solid was filtered, washed with methanol (100.0 ml), suck dried to afford crude /V-[5-(4-bromophenyl)-6-[2-[(5-bromo-2- pyrimidinyl)oxy] ethoxyJ^-pyrimidinylJ-Af-propylsulfamide [Macitentan]. [Yield = 121.5 gm; Purity (HPLC) = 99.68percent]. Purification of Macitentan ( I ) Macitentan crude (121.5 gm, 0.202 mol) wet solid was dissolved at 65-70°C in methanol (2400.0 ml) and decolorized with activated charcoal. The resulting solution was gradually cooled to room temperature then cooled to 0- 5°C and maintained for 45-60 min. Obtained solid was filtered, washed with methanol (100.0 ml), suck dried and dried under vacuum at 55-60°C to afford highly pure Macitentan. [Yield = 111.5 gm; Purity (HPLC) = 99.94percent]. (M + H)+/z= 589.0. 1H NMR (CDCIa): delta 8.49 (s, 2 H), 8.45 (s, 1H), 7.57-7.54 (m, 2H), 7.16-7.12 (m, 2H), 6.87 (s, 1 H), 5.60-5.57 (t, J = 6.24 Hz, 1 H), 4.71- 4.69 (m, 2H), 4.61-4.59 (m, 2H), 2.97-2.92 (q, 2H), 1.61-1.52 (h, J = 7.36 Hz, 2H), 0.94-0.91 (t, J = 7.36 Hz, 3H). 13C NMR (CDC ): delta 11.24, 21.97, 44.62, 64.68, 65.48, 104.80, 111.85, 121.31, 129.48, 131.35, 132.51 , 155.82, 156.41 , 159.68, 163.10, 165.75.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,32779-36-5, 5-Bromo-2-chloropyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; MEGAFINE PHARMA (P) LTD.; MATHAD Vijayavitthal Thippannachar; NIPHADE NAVNATH CHINTAMAN; KABRA SANJAY RAMESHWAR; JAGTAP KUNAL MADHAV; PAWAR ANIL RAMBHAU; (43 pag.)WO2016/203489; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 32779-36-5, 5-Bromo-2-chloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 32779-36-5, blongs to pyrimidines compound. SDS of cas: 32779-36-5

A mixture of 5-bromo-2-chloropyrimidine (1 g, 5.18 mmol), dimethylamine hydrochloride (1.26 g, 15.6 mmol) and K2C03 (2.16 g, 15.6 mmol) in EtOH (15 mL) was heated to 120C for 16h. After cooling, the solvent was evaporated off and the residue was used for next step without further purification. LCMS (m/z): 202.1/203.1 [M+H]”7 [M+2H]+

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,32779-36-5, its application will become more common.

Reference:
Patent; EPIZYME, INC.; DUNCAN, Kenneth, W.; CHESWORTH, Richard; MUNCHHOF, Michael, John; JIN, Lei; WO2014/100695; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia