Category: 32998-03-1

Related Products of 32998-03-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 32998-03-1, name is 2,6-Dichloro-N-methylpyrimidin-4-amine. This compound has unique chemical properties. The synthetic route is as follows.

Compound 58; c/s-4-({4-(methylamino)-6-[(phenylmethyl)amino]-2-pyrimidinyl}amino)-lambda/-{[2- (trifluoromethy^phenyllmethyljcyclohexanecarboxamide; Step 1 : Preparation of c/’s-4-{[4-chloro-6-(methylamino)-2-pyrimidinyllamino}-lambda/-{[2- (trifluoromethvDphenyllmethyllcvclohexanecarboxamide; To a solution of 2,6-dichloro-lambda/-methyl-4-pyrimidinamine (360 mg, 2.0 mmol) and c/s-4-amino-lambda/-{[2-(trifluoromethyl)phenyl]methyl}cyclohexanecarboxamide (Intermediate 1 ) trifluoroacetate (829 mg, 2.0 mmol), in MeCN/H2O (1 :1 , 5 ml.) was added 1 N NaOH solution until a pH of 12 was achieved. The mixture was irradiated in the microwave for 4 hours at 17O0C, at which time LCMS indicated the formation of the desired product. The reaction mixture was extracted with EtOAc (2×50 ml_), washed with water (2×50 ml_), dried (Na2SO4), and concentrated to afford a waxy solid. The crude material was purified by column chromatography (Gradient from 0-5% MeOH in CH2CI2) to afford 300 mg (0.68 mmol, 34%) of a colorless wax MS (ES+) m/e 442 [M + H]+. Regiochemistry was verified by 2D NMR analysis.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 32998-03-1, 2,6-Dichloro-N-methylpyrimidin-4-amine.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2008/105968; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 32998-03-1, name is 2,6-Dichloro-N-methylpyrimidin-4-amine. A new synthetic method of this compound is introduced below., COA of Formula: C5H5Cl2N3

EXAMPLE 3 4-Methylamino-2,6-di-1-pyrrolidinopyrimidine (V) Pyrrolidine (IV, 25 ml) is added (exothermic) to 2,6-dichloro-4-methylaminopyrimidine (III, EXAMPLE 1, 1.81 g). The mixture is stirred and heated under reflux for 23 hours, then is allowed to cool and concentrated under reduced pressure. The residue is partitioned between ethyl acetate and aqueous potassium bicarbonate, the phases separated and organic phase is concentrated to give a solid. The solid is crystallized from hexane to give the title compound, mp 100.5-103; NMR (CDCl3) 4.74, 3.51, 3.43, 2.81 and 1.9delta; CMR (CDCl3) 164.50, 161.92, 160.18, 70.78, 46.06, 45.85, 28.47, 25.44, 25.19delta. Alternatively, the title compound can be obtained by the reaction of 4-chloro-2,6-di-1-pyrrolidinylpyrimidine and methylamine (II) in pyridine in a pressure tube at 100, MS (M+) 247.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 32998-03-1, 2,6-Dichloro-N-methylpyrimidin-4-amine.

Reference:
Patent; The Upjohn Company; US5502187; (1996); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 32998-03-1 , The common heterocyclic compound, 32998-03-1, name is 2,6-Dichloro-N-methylpyrimidin-4-amine, molecular formula is C5H5Cl2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE 5 2,6-bis-(2–Hydroxyethyl)methylamino-4-methylaminopyrimidine (V) A mixture of 2,6-dichloro-4-methylamino-pyrimidine (III, EXAMPLE 1, 1.78 g) and 2-(methylamino)ethanol (IV, 25 ml) is heated under reflux for about 18 hours, then is allowed to cool and is diluted with ethyl acetate (100 ml). The mixture is washed with aqueous potassium bicarbonate (0.5N), water (4*25 ml) and with saline (50 ml). The aqueous phases are backwashed with ethyl acetate. The organic extracts are combined, dried and concentrated to give the title compound, NMR (CDCl3) 4.82, 3.8, 3.68, 3.11, 3.00 and 2.84delta; CMR (CDCl3) 164.0, 161.76, 71.16, 63.08, 62.47, 52.64, 36.91, 36.49 and 28.35delta.

The synthetic route of 32998-03-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; The Upjohn Company; US5502187; (1996); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 32998-03-1, name is 2,6-Dichloro-N-methylpyrimidin-4-amine. This compound has unique chemical properties. The synthetic route is as follows. name: 2,6-Dichloro-N-methylpyrimidin-4-amine

EXAMPLE 42 N-Methyl-2,6-di-(4′-t-butoxycarbonyl-1′-piperazinyl)-4-pyrimidinamine (V) A mixture of 2,6-dichloro-4-methylaminopyrimidine (III, EXAMPLE 1, 5 g) dissolved in o-xylene (300 ml) is treated with mono-t-BOC-piperazine (IV, 20.92 g) and the reaction mixture is refluxed for 50 hr. The reaction mixture is concentrated under reduced pressure. The resulting residue is partitioned between chloroform and saturated sodium bicarbonate. The organic layer is separated, washed with saline, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The crude product (24.53 g) is chromatographed on silica gel (590 g). The column is packed and eluted with chloroform/acetone (97/3). An initial fraction of 400 ml is collected followed by 8 ml fractions. Based on their TLC homogeneity, fractions 132-326 are combined and concentrated to give the title compound, NMR (CDCl3, TMS) 4.94, 4.96, 3.75-3.65, 3.55-3.4, 2.85 and 1.48 8; MS (m/z) M+ (found) 477, other ions at m/z 420, 376, 364, 348, 321,265, 221, 178, 164 and 57.

With the rapid development of chemical substances, we look forward to future research findings about 32998-03-1.

Reference:
Patent; The Upjohn Company; US5502187; (1996); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia