Category: 330786-24-8

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 330786-24-8, Name is 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, molecular formula is , belongs to pyrimidines compound. In a document, author is Mane, Smita G., Quality Control of 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine.

Design, synthesis, molecular docking, anti-proliferative and anti-TB studies of 2H-chromen-8-azaspiro[4.5]decane-7,9-dione conjugates

In this work, a series of new 8-[(substituted 2-oxo-2H-chromen-4-yOmethyl]-8-azaspiro[4.5]decane-7,9-dione derivatives (1a – 1l) is synthesized and characterized by H-1 NMR, C-13 NMR, FT-IR, GC-MS and elemental analysis. In addition, the structure of compound 1k has been elucidated using single crystal X-ray diffraction techniques. The synthesized compounds are screened for their anticancer and anti-TB activity. Preliminary anticancer results showed that compounds (1a- 1l) exhibit moderate to potent activity against MDA-MB-231, A549, HT-29 and Hela cancer cell lines. Compound if exhibited the most potent activity against MDA-MB-231cell line with IC50 value of 9.05 mu M concentration, compound lg and 1h showed potent activity against A549 cell line with IC50 value of 7.05 and 13.31 mu M concentration respectively. Compound 1j showed good cytotoxicity against Hela cell line with IC50 of 16.14 mu M, whereas, compound 1l is found to be moderately active against HT-29 cell line with IC50 of 18.07 mu M. Anti-tubercular activity revealed that compound 1c, 1d, 1g, 1h and 1j have significant activity against MTBH(37)Rv strain with MIC 0.78, 1.56, 0.19, 0.39 and 0.78 mu g/mL respectively. Further, to investigate the mechanism of anti-TB activity and detailed intermolecular interactions between the synthesized compounds, molecular docking studies are performed. (C) 2020 Elsevier B.V. All rights reserved.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 330786-24-8, in my other articles. Quality Control of 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 330786-24-8, Name is 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, SMILES is NC1=C2C(NN=C2C3=CC=C(OC4=CC=CC=C4)C=C3)=NC=N1, belongs to pyrimidines compound. In a document, author is Shukla, Manojkumar R., introduce the new discover, Application In Synthesis of 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine.

Discovery of a Potent and Selective PI3K delta Inhibitor (S)-2,4-Diamino-6-((1-(7-fluoro-1-(4-fluorophenyl)-4-oxo-3-phenyl-4H-quinolizin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile with Improved Pharmacokinetic Profile and Superior Efficacy in Hematological Cancer Models

PI3K delta inhibitors have been approved for B-cell malignancies like CLL, small lymphocytic lymphoma, and so forth. However, currently available PI3K delta inhibitors are nonoptimal, showing weakness against at least one of the several important properties: potency, isoform selectivity, and/or pharmacokinetic profile. To come up with a PI3K delta inhibitor that overcomes all these deficiencies, a pharmacophoric expansion strategy was employed. Herein, we describe a systematic transformation of a three-blade propeller shaped lead, 2,3-disubstituted quinolizinone 11, through a 1,2-disubstituted quinolizinone 20 to a novel four-blade propeller shaped 1,2,3-trisubstituted quinolizinone 34. Compound 34 has excellent potency, isoform selectivity, metabolic stability across species, and exhibited a favorable pharmacokinetic profile. Compound 34 also demonstrated a differentiated efficacy profile in human germinal center B and activated B cell-DLBCL cell lines and xenograft models. Compound 34 qualifies for further evaluation as a candidate for monotherapy or in combination with other targeted agents in DLBCLs and other forms of iNHL.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 330786-24-8 is helpful to your research. Application In Synthesis of 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Product Details of 330786-24-8, 330786-24-8, Name is 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, SMILES is NC1=C2C(NN=C2C3=CC=C(OC4=CC=CC=C4)C=C3)=NC=N1, belongs to pyrimidines compound. In a document, author is Wen, Hui-Min, introduce the new discover.

A novel expanded metal-organic framework for balancing volumetric and gravimetric methane storage working capacities

A novel expanded metal-organic framework (UTSA-111a) with functional pyrimidine sites exhibits simultaneously high gravimetric and volumetric methane storage working capacities of 309 cm(3) (STP) g(-1) and 183 cm(3) (STP) cm(-3) at 298 K and 5.8-65 bar.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 330786-24-8. Product Details of 330786-24-8.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 330786-24-8, Name is 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, SMILES is NC1=C2C(NN=C2C3=CC=C(OC4=CC=CC=C4)C=C3)=NC=N1, in an article , author is Hao, Peng-Fei, once mentioned of 330786-24-8, Quality Control of 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine.

Agriculture organic wastes fermentation CO2 enrichment in greenhouse and the fermentation residues improve growth, yield and fruit quality in tomato

The concern about fossil fuel shortage and environmental pollution highlighted the necessity to improve the output performance in facility agriculture. We investigated the influence of a climate-smart agricultural production system, namely agriculture organic waste fermentation CO2 enrichment technology (AOWF + CO2) on greenhouse tomato production and the effect of fermentation residues from AOWF + CO2. AOWF + CO2 exhibited positive effect on tomato growth, yield and fruit quality. Soluble sugar, lycopene and carotenoid contents in tomato fruits increased by 24.1%, 53% and 129%, respectively, while the nitrate content decreased by 10.7% when compared with control. The metabolome and proteome studies revealed significant up-regulation of secondary metabolisms, and the differentially expressed proteins (DEPs) were significantly enriched in purine, pyrimidine and linoleic acid metabolism pathways. The fermentation residues also significantly increased tomato growth, yield and fruit quality. It was estimated that each hectare greenhouse furnished with AOWF + CO2 could at least reduce 17951.5 kg CO(2)eq. emission, and store 5314.5 kg CO(2)eq. in soil. In conclusion, AOWF + CO2 and its residues recycling could accelerate tomato growth and productivity. This demonstrates a new climate-smart agriculture approach of reutilizing agricultural organic wastes to improve the sustainability of ecosystem. (C) 2020 Elsevier Ltd. All rights reserved.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 330786-24-8, you can contact me at any time and look forward to more communication. Quality Control of 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Synthetic Route of 330786-24-8, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 330786-24-8, Name is 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, SMILES is NC1=C2C(NN=C2C3=CC=C(OC4=CC=CC=C4)C=C3)=NC=N1, belongs to pyrimidines compound. In a article, author is Spallarossa, Andrea, introduce new discover of the category.

Bicyclic Basic Merbarone Analogues as Antiproliferative Agents

Pyrimido-pyrimidine derivatives have been developed as rigid merbarone analogues. In a previous study, these compounds showed potent antiproliferative activity and efficiently inhibited topoisomerase II alpha. To further extend the structure-activity relationships on pyrimido-pyrimidines, a novel series of analogues was synthesized by a two-step procedure. Analogues 3-6 bear small alky groups at positions 1 and 3 of the pyrimido-pyrimidine scaffold whereas at position 6a (4-chloro)phenyl substituent was inserted. The basic side chains introduced at position 7 were selected on the basis of the previously developed structure-activity relationships. The antiproliferative activity of the novel compounds proved to be affected by both the nature of the basic side chain and the substituents on the pyrimido-pyrimidine moiety. Derivatives 5d and 5e were identified as the most promising molecules still showing reduced antiproliferative activity in comparison with the previously prepared pyrimido-pyrimidine analogues. In topoisomerase II alpha-5d docking complex, the ligand would poorly interact with the enzyme and assume a different orientation in comparison with 1d bioactive conformation.

Synthetic Route of 330786-24-8, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 330786-24-8.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Application of 330786-24-8, Adding some certain compound to certain chemical reactions, such as: 330786-24-8, name is 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine,molecular formula is C17H13N5O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 330786-24-8.

3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (120.00 mg, 395.62 mumol) was weighed into a single-mouth flask and anhydrous tetrahydrofuran (10 ml) was added. , triphenylphosphine (311.30 mg, 1.19 mmol), cyclopentanol (34.08 mg, 395.62 mumol), diethyl azodicarboxylate (239.99 mg, 1.19 mmol) were added under argon atmosphere, and the reaction was monitored by TLC at room temperature overnight. complete. The reaction solution was concentrated and column chromatography afforded 117.00 mg of BTK-7 in a yield of 79.62%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 330786-24-8, 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shanghai Institute of Technology; Yao Zhiyi; Yang Yan; Xia Xiaoming; Xue Nannan; Shu Qisheng; Wang Qingxuan; Wang Dongsheng; (7 pag.)CN107827892; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 330786-24-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 330786-24-8 as follows.

Under nitrogen protection, Ph3P (29.2g, 112mmol), (3S)-hydroxy-1-tert-butoxycarbonylpiperidine (18.0g, 89.3mmol) was dissolved in 150ml of tetrahydrofuran, cooled to 0 C, the control temperature did not exceed A solution of DIAD (25.3 g, 125 mmol) in tetrahydrofuran (40 ml) was added at 5 C over 20-30 min. Then at 0~5CA solution of 4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine (28.4 g, 93.8 mmol) in tetrahydrofuran (150 ml) was added, Stir at room temperature for 5 h. Add 3.2 ml of water, then add zinc chloride (18.2 g, 134 mmol), stir to warm to 30-40 C for 2.5 h, cool to 0 C ~ 5, filter, and wash with tetrahydrofuran (50 ml ¡Á 2), remove the solvent by rotary evaporation The residual oil was slurried with ethyl acetate (300 ml), hexane (50 ml) was added, filtered, and the residue was washed with ethyl acetate (30 ml ¡Á 2), and the filtrate was water (100ml ¡Á 2), saturated brine (150ml) The organic layer was washed with anhydrous sodium sulfate, and the solvent was evaporated to remove the solvent. The residue was purified by the solvent. The content of Ph3PO was 3.81% (Comparative MgCl2: 32.4% by weight), and isopropanol (40 ml) was added to the residue to warm. Stirring at 50-60 C, cooling the crystals, filtering a small amount of cold isopropanol washing, product: 31.5 g (yield 80.2%), Ph3PO content: 0.28% (compared with MgCl 2 method: yield 85.2%; Ph3PO content: 14 wt%)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,330786-24-8, its application will become more common.

Reference:
Patent; Fujian Microbiology Institute; Zhao Xueqing; Cheng Jiawei; Lin Yanqin; Fan Lin; Chen Zhong; Xu Minhua; Yi Mingyan; (8 pag.)CN109232581; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 330786-24-8, name is 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine. A new synthetic method of this compound is introduced below., Safety of 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Example 1-1 : Preparation of (i?)-3-(4-phenoxyphenyl)-l-(pyrrolidin-3-yl)-lH-pyrazolo[3,4- Patent; PHARMACYCLICS, INC.; CHEN, Wei; LOURY, David, J.; MODY, Tarak, D.; WANG, Longcheng; WO2013/10136; (2013); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 330786-24-8 ,Some common heterocyclic compound, 330786-24-8, molecular formula is C17H13N5O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a solution of 8 (1 mmol) and substituted benzyl bromide 9 (1.2 mmol) in N, N-dimethylformamide (5 mL) was added K2CO3 (1.5 mmol) and the reaction mixture was stirred for 5 h at room temperature.The reaction solution was poured into water (50 mL). The suspension was filtered and the crude product was purified by silica gel column chromatography with dichloromethane/methanol (80/1-40/1) to give target compounds 10a – 10n.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 330786-24-8, 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ran, Fansheng; Liu, Yang; Liu, Meixia; Zhang, Daoguang; Wang, Peng; Dong, Junze; Tang, Wendi; Zhao, Guisen; Bioorganic Chemistry; vol. 89; (2019);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 330786-24-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 330786-24-8, name is 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine. This compound has unique chemical properties. The synthetic route is as follows.

Under nitrogen protection, 20 g of triphenylphosphine supported by nano-Fe3O4 was added to the three-necked flask (particle diameter 100 nm,PPh3 loading 1 mmol/g), adding intermediate (II) (3.04 g, 10 mmol),N-Boc-3S-hydroxypiperidine (III) (2.02 g, 10 mmol), diethyl azodicarboxylate (3.67 g, 21.1 mol)And 1,4-dioxane (100 mL), the reaction was stirred at 20 C until the intermediate (II) was consumed completely, and the reaction was stopped.The external magnet adsorbs the magnetic nano-load, and the reaction solution is decanted, and the nanoparticles are washed with 1,4-dioxane (50 mL¡Á2).The washing liquid and the reaction liquid were combined, concentrated under reduced pressure to (20 mL), and then added to 10 mol/L hydrochloric acid (40 mL), and the mixture was completely removed.Dichloromethane (50 mL x 3) was extracted and the aqueous phase was neutralized with saturated sodium carbonate to pH >Filtration and vacuum drying to obtain a solid intermediate (IV) (3.30 g, yield: 85.3%).No residual phenoxide was detected.

According to the analysis of related databases, 330786-24-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Hangzhou China-USA East China Pharmaceutical Co., Ltd.; Hangzhou East China Pharmaceutical Group New Drug Institute Co., Ltd.; Zhou Yubao; Yu Rui; Chen Yu; Hu Haiwen; (7 pag.)CN108623606; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia