Category: 33097-11-9

Synthetic Route of 33097-11-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 33097-11-9, name is 4,6-Dichloro-2-(methylthio)pyrimidine-5-carbaldehyde, molecular formula is C6H4Cl2N2OS, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 4; 4-Chloro-2-methylsulfinyl-8-(“4-trifluoromethyl-phenvD-8H- pyridor23-Patent; GLAXO GROUP LIMITED; WO2006/104917; (2006); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 33097-11-9, name is 4,6-Dichloro-2-(methylthio)pyrimidine-5-carbaldehyde, molecular formula is C6H4Cl2N2OS, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. COA of Formula: C6H4Cl2N2OS

After the compound obtained in Step 1 was dissolved in dichloromethane,N, N’-diisopropylamine was added at room temperature, and the reaction mixture was cooled to 0 C and 4,6-dichloro-2- (methylthio) pyrimidine-5-carbaldehyde was added, And stirred for 2 hours.The reaction mixture was extracted with dichloromethane and water.The organic layer was dried over magnesium sulfate and then distilled under reduced pressure.The resulting residue was purified by MPLC to obtain the title compound.

With the rapid development of chemical substances, we look forward to future research findings about 33097-11-9.

Reference:
Patent; Hanrim Pharmaceutical Co., Ltd.; Kim Gyeong-hui; Jin Jeong-uk; Lee Ji-hun; Kim Sin-ae; Jeong Gyeong-jin; Kim Jun-u; Min Sang-hyeon; Ryu Ji-hun; Lee Ju-seok; Lee Won-seok; Song Jae-yeong; Lee Eung-seok; Jeong Tae-cheon; Kim Jeong-ae; (35 pag.)KR2019/73673; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 33097-11-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 33097-11-9, name is 4,6-Dichloro-2-(methylthio)pyrimidine-5-carbaldehyde. This compound has unique chemical properties. The synthetic route is as follows.

4.17 6-Acetyl-7-methyl-2-(methylsulfanyl)pyrido[2,3-d]pyrimidine-4(3H)-one (13) To a stirred solution of aldehyde 1 (500 mg, 2.24 mmol) in 3.5 mL of DMF was added enamine 12 (250 mg, 2.52 mmol) followed by addition of a few drops of satd ethereal HCl. Mixture was stirred at ambient temperature for 5 h. Crystals formed were filtered, washed thoroughly with MeCN (10 mL) and dried at 110 C/5 Torr to give the titled compound (256 mg, 46%) as light pink powder, mp 265-267 C (MeCN; decomp.); numax(KBr) 3417 (br), 3008, 2731, 2625, 1726, 1716, 1690, 1627, 1524, 1426, 1371, 1345, 1263, 1227, 1163, 1108, 960, 794; deltaH (400 MHz, DMSO-d6, 60 C) 10.40 (1H, s, NH), 8.77 (1H, s, 5-H), 2.76 (3H, s, 7-CH3), 2.65 (3H, s, ?OCH3), 2.63 (3H, s, SCH3); deltaC (100.6 MHz, DMSO-d6, 60 C) 198.9 (COCH3), 165.1 (2-C), 164.0 (7-C), 161.3 (4-?), 157.3 (8a-C), 138.8 (5-C), 130.5 (6-C), 113.2 (4a-?), 29.8 (7-CH3), 24.6 (COCH3), 13.6 (SCH3); HRMS (ESI): MH+, found 250.0632. [C11H12N3O2S]+ requires 250.0645.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 33097-11-9, 4,6-Dichloro-2-(methylthio)pyrimidine-5-carbaldehyde.

Reference:
Article; Chizhova, Maria E.; Bakulina, Olga Yu.; Ivanov, Alexander Yu.; Lobanov, Pavel S.; Dar’in, Dmitrii V.; Tetrahedron; vol. 71; 36; (2015); p. 6196 – 6203;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia