Category: 332133-92-3

Application of 332133-92-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.332133-92-3, name is 4-(Tributylstannyl)pyrimidine, molecular formula is C16H30N2Sn, molecular weight is 369.1328, as common compound, the synthetic route is as follows.

A solution of compound 5 (175 mg, 0.19 mmol), compound 51 (103 mg, 0.28 mmol), Pd(PPh3)4 (22 mg, 0.02 mmol) in 1,4-dioxane (4 mL) was microwaved at 100 C for 40 minutes, LC-MS showed that the start materials was consumed up, stopped the reaction, poured into a mixture of DCM (60 mL) and H20 (50 mL), filtered through a pad of celite, the organic layer was separated, washed with brine, dried over anhydrous Na2S04, concentrate in vacuo, the residue was purified by column (DCM/MeOH 100/1 to 40/1) to give compound 52 (9 mg, 11% yield) as a white solid. MS (ESI) (M/Z): [M+H]+ =402.1

The chemical industry reduces the impact on the environment during synthesis 332133-92-3, I believe this compound will play a more active role in future production and life.

Reference:
Patent; ZHANG, Hai-Jun; (63 pag.)WO2018/217439; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 332133-92-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.332133-92-3, name is 4-(Tributylstannyl)pyrimidine, molecular formula is C16H30N2Sn, molecular weight is 369.1328, as common compound, the synthetic route is as follows.

A solution of compound 5 (175 mg, 0.19 mmol), compound 51 (103 mg, 0.28 mmol), Pd(PPh3)4 (22 mg, 0.02 mmol) in 1,4-dioxane (4 mL) was microwaved at 100 C for 40 minutes, LC-MS showed that the start materials was consumed up, stopped the reaction, poured into a mixture of DCM (60 mL) and H20 (50 mL), filtered through a pad of celite, the organic layer was separated, washed with brine, dried over anhydrous Na2S04, concentrate in vacuo, the residue was purified by column (DCM/MeOH 100/1 to 40/1) to give compound 52 (9 mg, 11% yield) as a white solid. MS (ESI) (M/Z): [M+H]+ =402.1

The chemical industry reduces the impact on the environment during synthesis 332133-92-3, I believe this compound will play a more active role in future production and life.

Reference:
Patent; ZHANG, Hai-Jun; (63 pag.)WO2018/217439; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 332133-92-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 332133-92-3, name is 4-(Tributylstannyl)pyrimidine. A new synthetic method of this compound is introduced below.

A mixture of 3~(2-amino-5~(bis(4-mefhoxybenzyl)amino)-8~bromo~ il,2,4]triazolo[l,5-c]pyrimidin-7-yl)benzonitrile (350 mg, 0.61 mmol), 4- (tributylstannyi)pyrimidine (210 pL, 0.67 mmol), ietrakis(triphenylphosphine)pailadium(0) (70 mg, 0.060 mmol), copper(l) iodide (23 mg, 0.12 mmol) and cesium fluoride (180 mg, 1.2 mmol) in dioxane (4.7 mL) was heated and stirred at 140 C for 30 min in a microwave reactor. The reaction mixture was then cooled to r.t, filtered through a Celite plug (washed with DCM), and concentrated. The resulting material was purified by silica gel column chromatography eluting with 0-20% MeOH/DCM to give the desired product. LC-MS calculated for C32H28N9O2 (M+H)+: m/z = 570.2; found 570 3.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,332133-92-3, its application will become more common.

Reference:
Patent; INCYTE CORPORATION; WANG, Xiaozhao; GAN, Pei; HAN, Heeoon; HUANG, Taisheng; MCCAMMANT, Matthew S.; QI, Chao; QIAN, Ding-Quan; WU, Liangxing; YAO, Wenqing; YU, Zhiyong; ZHANG, Fenglei; (284 pag.)WO2019/168847; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 332133-92-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 332133-92-3, name is 4-(Tributylstannyl)pyrimidine. A new synthetic method of this compound is introduced below.

A mixture of 3 -(8-amino-S -bromo-2-(pyridin-2-ylmethyl)- [1 ,2,4jtriazolo [1,5 – ajpyrazin-6-yl)benzonitrile (15 mg, 0.037 mmol), 4-(tributylstannyl)pyrimidine (20mg, 0.055 mmol), and copper(I) chloride (4.4 mg, 0.044 mmol), lithium chloride (1.9 mg, 0.044 mmol) and tetrakis(triphenylphosphine)palladium(0) (4.3 mg, 3.7 imol) in THF (1 mL) was purged with N2, and stirred at 90 C for 2 h. The reaction mixture was then cooled to room temperature, diluted with methanol, and purified via prepLCMS (pH 2, acetonitrile/water with TFA) to give the desired product as a TFA salt.LC-MS calculated for C22H16N9 (M+H): mlz = 406.2; found 406.2.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,332133-92-3, its application will become more common.

Reference:
Patent; INCYTE CORPORATION; HOANG, Gia; WANG, Xiaozhao; CARLSEN, Peter Niels; GAN, Pei; LI, Yong; QI, Chao; WU, Liangxing; YAO, Wenqing; YU, Zhiyong; ZHU, Wenyu; (333 pag.)WO2020/10197; (2020); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 332133-92-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 332133-92-3, name is 4-(Tributylstannyl)pyrimidine. A new synthetic method of this compound is introduced below.

A mixture of 3 -(8-amino-S -bromo-2-(pyridin-2-ylmethyl)- [1 ,2,4jtriazolo [1,5 – ajpyrazin-6-yl)benzonitrile (15 mg, 0.037 mmol), 4-(tributylstannyl)pyrimidine (20mg, 0.055 mmol), and copper(I) chloride (4.4 mg, 0.044 mmol), lithium chloride (1.9 mg, 0.044 mmol) and tetrakis(triphenylphosphine)palladium(0) (4.3 mg, 3.7 imol) in THF (1 mL) was purged with N2, and stirred at 90 C for 2 h. The reaction mixture was then cooled to room temperature, diluted with methanol, and purified via prepLCMS (pH 2, acetonitrile/water with TFA) to give the desired product as a TFA salt.LC-MS calculated for C22H16N9 (M+H): mlz = 406.2; found 406.2.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,332133-92-3, its application will become more common.

Reference:
Patent; INCYTE CORPORATION; HOANG, Gia; WANG, Xiaozhao; CARLSEN, Peter Niels; GAN, Pei; LI, Yong; QI, Chao; WU, Liangxing; YAO, Wenqing; YU, Zhiyong; ZHU, Wenyu; (333 pag.)WO2020/10197; (2020); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 332133-92-3, 4-(Tributylstannyl)pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 4-(Tributylstannyl)pyrimidine, blongs to pyrimidines compound. Application In Synthesis of 4-(Tributylstannyl)pyrimidine

A mixture of 3 -(8-amino-S -bromo-2-(2-chloro-6-fluorobenzyl)-[1,2,4jtriazolo[1,5-ajpyrazin-6-yl)benzonitrile(51 mg, 0.11 mmol), CuT (4.2 mg,0.021 mmol), CsF (33 mg, 0.22 mmol), tetrakis(triphenylphosphine)palladium(0) (12mg, 0.012 mmol), and 4-(tributylstannyl)pyrimidine (49 mg, 0.13 mmol) in 1,4- dioxane (2 mL) was heated at 140 C for 1 h in a microwave reactor. The reaction mixture was concentrated under vacuum and the resulting residue was purified with flash chromatography to give the desired product as a light yellow oil. LC-MScalculated for C23H15C1FN8 (M+H): m/z = 457.1 found 457.1.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,332133-92-3, 4-(Tributylstannyl)pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; INCYTE CORPORATION; HOANG, Gia; WANG, Xiaozhao; CARLSEN, Peter Niels; GAN, Pei; LI, Yong; QI, Chao; WU, Liangxing; YAO, Wenqing; YU, Zhiyong; ZHU, Wenyu; (333 pag.)WO2020/10197; (2020); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia