Category: 34289-60-6

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 34289-60-6, name is 4,6-Dimethylpyrimidin-2-ol hydrochloride, the common compound, a new synthetic route is introduced below. COA of Formula: C6H9ClN2O

General procedure: To themixture of 2hydroxy(mercapto)4,6dimethylpyrimidine hydrochloride (0.0375 mol) and corresponding aldehyde (0.075 mol)in 100 mL of ethanol 7.5 mL of concentrated HCl was added.Reaction mixture was heated to reflux for 5 h, then cooled down,and the bright red hydrochloride precipitate was separated byfiltration and washed with acetone. To transform salt into freebase the precipitate was treated with 10% waterethanol solutionof K2CO3. Formed light yellow precipitate was separated byfiltration and dried in air.2Hydroxy4,6bis[2(4methylphenyl)vinyl]pyrimidine (5).Yield 85%, yellow powder, m.p. >250 . Found (%): C, 80.35;H, 6.08; N, 8.42. C22H20N2O. Calculated (%): C, 80.46; H, 6.14;N, 8.53. IR (nujol), nu/cm-1: 3434. 1 NMR (DMSOd6), delta: 3.43(s, 6 , 2 Me); 6.9 (s, 1 H, OH); 7.02 (d, 2 , 2 =, J = 15.3 Hz); 7.21 (s, 1 , pyrimidine); 7.42 (d, 4 , 2 64, J = 7.8 Hz); 7.68(d, 4 , 2 64, J = 7.8 Hz); 7.92 (d, 2 , 2 =, J = 15.3 Hz).

The synthetic route of 34289-60-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Komissarova; Lunegov; Mayorova; Shklyaeva; Abashev; Russian Chemical Bulletin; vol. 65; 9; (2016); p. 2291 – 2298; Izv. Akad. Nauk, Ser. Khim.; 9; (2016); p. 2291 – 2298,8;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 34289-60-6, name is 4,6-Dimethylpyrimidin-2-ol hydrochloride. This compound has unique chemical properties. The synthetic route is as follows. Safety of 4,6-Dimethylpyrimidin-2-ol hydrochloride

Add 160 mg (1 mmol) to a 100 mL eggplant bottle 2-hydroxy-4,6-dimethylpyrimidine hydrochloride, 318 mg (3 mmol) benzaldehyde and 0.1 mL (1.2 mmol) concentrated hydrochloric acid,Anhydrous ethanol (40 mL) was added to dissolve the reaction, and the mixture was heated under reflux at 80 C for 24h.After the reaction is completed, the solvent is distilled off under reduced pressure.Add a saturated sodium bicarbonate aqueous solution and stir to remove the acid.The crude product was washed with water and dried and purified by column chromatography (methanol: dichloromethane = 1:10).0.21 g of 2-hydroxy-4,6-distyrylpyrimidine was obtained in a yield of 70%.

With the rapid development of chemical substances, we look forward to future research findings about 34289-60-6.

Reference:
Patent; Ocean University of China; Jiang Tao; Zhang Lijuan; Tong Sheng; Zhang Meng; (30 pag.)CN105198820; (2019); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 34289-60-6, name is 4,6-Dimethylpyrimidin-2-ol hydrochloride. This compound has unique chemical properties. The synthetic route is as follows. Safety of 4,6-Dimethylpyrimidin-2-ol hydrochloride

Add 160 mg (1 mmol) to a 100 mL eggplant bottle 2-hydroxy-4,6-dimethylpyrimidine hydrochloride, 318 mg (3 mmol) benzaldehyde and 0.1 mL (1.2 mmol) concentrated hydrochloric acid,Anhydrous ethanol (40 mL) was added to dissolve the reaction, and the mixture was heated under reflux at 80 C for 24h.After the reaction is completed, the solvent is distilled off under reduced pressure.Add a saturated sodium bicarbonate aqueous solution and stir to remove the acid.The crude product was washed with water and dried and purified by column chromatography (methanol: dichloromethane = 1:10).0.21 g of 2-hydroxy-4,6-distyrylpyrimidine was obtained in a yield of 70%.

With the rapid development of chemical substances, we look forward to future research findings about 34289-60-6.

Reference:
Patent; Ocean University of China; Jiang Tao; Zhang Lijuan; Tong Sheng; Zhang Meng; (30 pag.)CN105198820; (2019); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 34289-60-6, name is 4,6-Dimethylpyrimidin-2-ol hydrochloride, the common compound, a new synthetic route is introduced below. Recommanded Product: 34289-60-6

General procedure: An equimolar mixture (0.0125 mol) of 2-hydroxypyrimidines 1-2 and a corresponding arylcarboxaldehyde in 80 ml of ethanol was stirred for about 15min and then treated with 2.5 mL of HCl (cc). The obtained reaction mixture was heated under reflux for 6 h togive the corresponding hydrochlorides as red solids, which were then neutralized by 10% aqueous-alcoholic solution of carbonate of potassium. The resulting products (yellow solids) were filtered off, washed by hotethanol and dried in the air.

The synthetic route of 34289-60-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Komissarova, Ekaterina A.; Sosnin, Evgenii; Shklyaeva, Elena V.; Osorgin, Irina V.; Abashev, Georgii G.; Arkivoc; vol. 2017; 3; (2017); p. 105 – 120;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 34289-60-6 , The common heterocyclic compound, 34289-60-6, name is 4,6-Dimethylpyrimidin-2-ol hydrochloride, molecular formula is C6H9ClN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: An equimolar mixture (0.0125 mol) of 2-hydroxypyrimidines 1-2 and a corresponding arylcarboxaldehyde in 80 ml of ethanol was stirred for about 15min and then treated with 2.5 mL of HCl (cc). The obtained reaction mixture was heated under reflux for 6 h togive the corresponding hydrochlorides as red solids, which were then neutralized by 10% aqueous-alcoholic solution of carbonate of potassium. The resulting products (yellow solids) were filtered off, washed by hotethanol and dried in the air.

The synthetic route of 34289-60-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Komissarova, Ekaterina A.; Sosnin, Evgenii; Shklyaeva, Elena V.; Osorgin, Irina V.; Abashev, Georgii G.; Arkivoc; vol. 2017; 3; (2017); p. 105 – 120;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 34289-60-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 34289-60-6 as follows.

In a 25 ml round bottom flask with stirring bar was combined 2-hydroxy-4,6- dimethylpyrimidine hydrochloride, 2.05 g, cesium carbonate, 5.5g, and dimethyl formamide, 8.5 ml. The mix was stirred 30 minutes, then intermediate 1 c, 1.3g, was added. The resulting mix was heated at 80 0C overnight. TLC with 1 : 1 ethyl acetate/hexanes on silica showed complete conversion to new lower RF spot. The reaction was diluted with water, and extracted with ethyl acetate. The organic layer was washed twice with water. The combined aqueous layers were back extracted with ethyl acetate. The combined organic layers were washed with brine, dried over magnesium sulfate, and then concentrated in vacuo to provide methyl 9-{3-[(4,6-dimethylpyrimidin-2-yl)oxy]propyl}- 2,3,4,9-tetrahydro-lH-carbazole-6-carboxylate as an orange oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,34289-60-6, its application will become more common.

Reference:
Patent; ITHERX PHARMACEUTICALS, INC.; WO2009/103022; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.34289-60-6, name is 4,6-Dimethylpyrimidin-2-ol hydrochloride, molecular formula is C6H9ClN2O, molecular weight is 160.6015, as common compound, the synthetic route is as follows.COA of Formula: C6H9ClN2O

Add 0.160 g (1 mmol) of 2-hydroxy-4,6-dimethylpyrimidine hydrochloride to a 100 mL eggplant-shaped bottle,0.408 g (3 mmol) of 4-methoxybenzaldehyde and 0.1 mL (1.2 mmol) of concentrated hydrochloric acid,Add absolute ethanol (40 mL) to dissolve the reaction.Heat to reflux at 80 C for 24h.After the reaction is completed, the solvent is distilled off under reduced pressure.Add a saturated aqueous sodium bicarbonate solution and stir well to precipitate a solid.The crude product was washed three times with water and dried, and then separated and purified by column chromatography (methanol: dichloromethane = 1:10).0.252 g of 2-hydroxy-4,6-bis (4-methoxystyryl) pyrimidine is obtained,The yield was 70%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,34289-60-6, 4,6-Dimethylpyrimidin-2-ol hydrochloride, and friends who are interested can also refer to it.

Reference:
Patent; Ocean University of China; Jiang Tao; Zhang Lijuan; Tong Sheng; Zhang Meng; (30 pag.)CN105198820; (2019); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia