Synthetic Route of 343-67-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 343-67-9, name is Ethyl 4-hydroxy-2-(trifluoromethyl)pyrimidine-5-carboxylate. This compound has unique chemical properties. The synthetic route is as follows.
Intermediate B2-Ethyl 2-trifluoromethyl-4-chloropyrimidine-5-carboxylate To a solution of ethyl 4-hydroxy-2-trifluorormethylpyrimidine-5-carboxylate (51.8 g) in dichloromethane (600 ml) cooled in an ice bath was added oxalyl chloride (57.4 ml) followed by dimethylformamide (0.2 ml).The mixture was stir at room temperature for 16 h and then evaporated.toluene was added and evaporated.The residue was dissolved in dichloromethane, washed with water, dried (MgSO4) and evaporated to give the title compound as an orange oil (55.7 g, 100%).1H-NMR (CDCl3) delta 9.25 (1H, s), 4.51 (2H, q), 1.46 (3H, t); 13C-NMR (CDCl3) delta 126.0 (2C), 161.1, 158.1 (q, J=39 Hz), 127.0, 118.9 (q, J=276 Hz), 63.5, 14.4.
According to the analysis of related databases, 343-67-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SmithKline Beecham p.l.c.; US2004/167142; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia