Category: 3438-46-8

Related Products of 3438-46-8 ,Some common heterocyclic compound, 3438-46-8, molecular formula is C5H6N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

3-Methyl-pyrimidine [(9. 41] g, 100 mmol), potassium permanganate (26.9 g) and sodium carbonate (10.6 g) was refluxed in water (100 ml) for 72 h followed by filtration through celite. The filtrate was washed with several portions of DCM and EtOAc before acidification with conc. HC1. The formed precipitate was collected and washed with water to yield 1.37 g of the title compound as a white solid. 1H NMR (DMSO-d6) d (ppm): 13.94 (br. s, 1H), 9.37 (d, 1H), 9.07 (d, 1H), 8.01 (dd, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3438-46-8, its application will become more common.

Reference:
Patent; ASTRA ZENECA AB; NPS PHARMACEUTICALS, INC.; WO2004/14881; (2004); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 3438-46-8, 4-Methylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 3438-46-8, blongs to pyrimidines compound. SDS of cas: 3438-46-8

A mixture of 4-methylpyrimidine (22) (10 g, 106 mmol), N,Ndimethylformamidedimethylacetal (DMFDMA) (38 g, 319 mmol)and DMF (46.6 g, 637 mmol) was stirred in a sealed-tube at140 C for 24 h. After cooling, the solution was evaporated in vacuoto yield the title compound 23 (15.08 g, 95%). 1H NMR (CDCl3) d:8.73 (br s, 1H), 8.22 (d, J = 5.5 Hz, 1H), 7.77 (d, J = 12.9 Hz, 1H),6.72 (dd, J = 5.5, 12.9 Hz, 1H), 5.00 (d, J = 12.9 Hz, 1H), 2.96 (s, 6H).

The synthetic route of 3438-46-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Hasumi, Koichi; Sato, Shuichiro; Saito, Takahisa; Kato, Jun-Ya; Shirota, Kazuhiko; Sato, Jun; Suzuki, Hiroyuki; Ohta, Shuji; Bioorganic and Medicinal Chemistry; vol. 22; 15; (2014); p. 4162 – 4176;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 3438-46-8, Adding some certain compound to certain chemical reactions, such as: 3438-46-8, name is 4-Methylpyrimidine,molecular formula is C5H6N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3438-46-8.

To a solution of 4-methylpyrimidine (543mg, 5.8mmol) in THF (30ml_) was added NaHMDS (1 M in THF, 12ml_, 12mmol) slowly at rt. The reaction mixture was stirred at rt for 30 min and a solution of ethyl 2,3-dihydrobenzo[b][1 ,4]dioxine-6-carboxylate (1 g, 4.8mmol) in THF (5ml_) was added slowly at rt. The reaction mixture was stirred at rt for 2 h. The TLC showed the reaction to be complete. The reaction mixture was poured into saturated aq NH4CI (50ml_) and extracted with EtOAc (3x50ml_). The organics were washed with brine (100ml_), dried (Na2S04), filtered and concentrated under reduced pressure. The crude residue was enriched up to 80% purity by trituration with pentane (25ml_), filtered and dried under reduced pressure to afford 1-(2,3-dihydrobenzo[b][1 ,4]dioxin-6-yl)-2-(pyrimidin-4-yl)ethan-1-one as a yellow solid. Yield: 1 g (81 %). MS (ESI+) for CHNOS m/z 257.18 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3438-46-8, 4-Methylpyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; DISCUVA LTD.; MEO, Paul; KHAN, Nawaz; CHARRIER, Cedric; (252 pag.)WO2019/86890; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 3438-46-8 ,Some common heterocyclic compound, 3438-46-8, molecular formula is C5H6N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

PREPARATION H 4-Formylpyrimidine A solution of 4-methylpyrimidine (10 g, 0.106 mole) in 100 ml dioxane was treated with 11.8 g selenium dioxide at room temperature and the mixture was heated at 100 C. for 15 hours. After adding 2.5 g selenium dioxide, heating was continued one hour, the mixture cooled, filtered, and the cake washed with ethyl acetate. The filtrate and washings were evaporated to dryness in vacuo . The residual dark oil was taken up in methylene chloride, filtered and the solvent evaporated. The residue was crystallized from a small amount of methylene chloride to provide the title aldehyde. 1H-NMR(CDCl3)ppm (delta): 7.87 (dd, 1H), 9.06 (d, 1H), 9.43 (d, 1H), 10.0 (s, 1H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3438-46-8, its application will become more common.

Reference:
Patent; PFIZER INC.; EP150984; (1991); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 3438-46-8, 4-Methylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 4-Methylpyrimidine, blongs to pyrimidines compound. Quality Control of 4-Methylpyrimidine

General procedure: Methyldiazine derivative (1mmol) and compound 3 (1.1equiv per methyl group) were dissolved in THF (20mL). tBuOK (1.5equiv per methyl group) was slowly added at room temperature. The solution, which immediately turned brown, was then refluxed overnight. After cooling, water was added, THF was evaporated and the mixture extracted with CH2Cl2, dried over MgSO4 and the solvent removed under vacuum.

The synthetic route of 3438-46-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Achelle, Sylvain; Kahlal, Samia; Saillard, Jean-Yves; Cabon, Nolwenn; Caro, Bertrand; Robin-Le Guen, Francoise; Tetrahedron; vol. 70; 17; (2014); p. 2804 – 2815;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia