Category: 3438-48-0

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3438-48-0, name is 4-Phenylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 3438-48-0

General procedure: A stirred mixture of pyrimidine 1 (2.5 mmole), 2-bromoacetophenone 2 (2.5 mmole) and non-symmetrical electron deficient alkynes 3 (3.5 mmole) in 15 mL 1,2-epoxybutane was placed into an sealed microwave reactor at120 C for 30 min. The reaction mixture was cooled to room temperature, partly of the solvent was removed in vacuum, 5mL of MeOH was added under a gentle stirring and themixture was left overnight at 5-10 C . The solid formed was filtered-off, washed on the filter with a mixture of diethylether-MeOH 2:1 and crystallized from CHCl3/MeOH.

With the rapid development of chemical substances, we look forward to future research findings about 3438-48-0.

Reference:
Article; Georgescu, Emilian; Georgescu, Florentina; Draghici, Constantin; Cristian, Liliana; Popa, Marcel Mirel; Dumitrascu, Florea; Combinatorial Chemistry and High Throughput Screening; vol. 16; 10; (2013); p. 851 – 857;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3438-48-0, name is 4-Phenylpyrimidine, molecular formula is C10H8N2, molecular weight is 156.18, as common compound, the synthetic route is as follows.Recommanded Product: 3438-48-0

General procedure: To the mixture of an appropriate 4-substititedphenylpyrimidine (0.06mol) and acetamide (500mL), concentrated sulfuric acid (20mL) was added drop-wise at the temperature of 0-10C. Upon the completion of addition, 30% H2O2 (50mL) and saturated FeSO4·7H2O (aq. 100mL) were added drop-wise at the same time at the temperature of 0-10C. The reaction mixture the was stirred at 10-15C for 0.5h and then poured into water (2000mL), basified with potassium hydroxide to pH 9, and extracted with dichloromethane (200mL×3). The combined extracts were washed with brine (200mL×2), dried over anhydrous Na2SO4, and concentrated in vacuum to give the corresponding 4-substititedphenylpyrimidine-2-carboxamides as white solids in a moderate yield.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3438-48-0, 4-Phenylpyrimidine, and friends who are interested can also refer to it.

Reference:
Article; Tang, Qidong; Zhao, Yanfang; Du, Xinming; Chong, Lian’E; Gong, Ping; Guo, Chun; European Journal of Medicinal Chemistry; vol. 69; (2013); p. 77 – 89;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3438-48-0, name is 4-Phenylpyrimidine, molecular formula is C10H8N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 4-Phenylpyrimidine

(Step 1: Synthesis of di-mu-chloro-bis[bis(4-phenylpyrimidine)iridium(III)] (abbreviation: [Ir(ppm)2Cl]2))First, into a three-neck flask equipped with a reflux pipe were put 30 mL of 2-ethoxyethanol, 10 mL of water, 0.67 g of a ligand 4-phenylpyrimidine (abbreviation: Hppm), 0.50 g of iridium chloride (IrCl3-HCl H20), and the air in the three-neck flask was replaced with nitrogen. After that, the mixture was heated and refluxed for 13 hours to be reacted. The reacted solution was cooled naturally to room temperature and filtered. The substance obtained by the filtration was washed with ethanol to give a dinuclear complex [Ir(ppm)2Cl]2 (red powder, yield of 42 %). A synthesis scheme (d-1) of Step 1 is shown below.

With the rapid development of chemical substances, we look forward to future research findings about 3438-48-0.

Reference:
Patent; SEMICONDUCTOR ENERGY LABORATORY CO., LTD.; INOUE, Hideko; YAMAGUCHI, Tomoya; SHITAGAKI, Satoko; USHIKUBO, Takahiro; SEO, Satoshi; YAMADA, Yui; NOWATARI, Hiromi; WO2012/53627; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 3438-48-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3438-48-0, name is 4-Phenylpyrimidine, molecular formula is C10H8N2, molecular weight is 156.18, as common compound, the synthetic route is as follows.

General procedure: A mixture of a 4-substituted pyrimidine (2 mmol), 0.53 g3-(2-bromoacetyl)-2H-chromen-2-one (2 mmol), and anactivated alkyne (2.5 mmol) in 40 cm3 1,2-epoxybutanewas heated at reflux temperature for 24 h. The solvent waspartly removed under vacuum, 10 cm3 of MeOH wasadded and the mixture was left overnight at room temperature.The solid formed was filtered, washed on the filterwith a mixture of MeOH/diethyl ether 1:1 and crystallizedfrom CHCl3/MeOH. Ethyl 3-phenyl-7-(2-oxo-2H-chromen-3-yl)-carbonylpyrrolo[1,2-c]pyrimidine-5-carboxylate(13, C26H18N2O5)Yellow crystals; yield: 0.51 g (58 %); m.p.: 273-275 C; 1HNMR (CDCl3 ? TFA, 300 MHz): d = 1.48 (t, J = 7.1 Hz,3H, CH3), 4.52 (q, J = 7.1 Hz, 2H, CH2), 7.49-7.54, 7.63-7.65, 7.77-7.90 (3 m, 9H, 5 H-Phenyl, 4 H-Coum), 8.39 (s,1H, H-6), 8.45 (s, 1H, H-Coum), 8.61 (s, 1H, H-4), 11.29 (s,1H, H-1) ppm; 13C NMR (CDCl3 ? TFA, 75 MHz):d = 14.2 (CH3), 63.1 (CH2), 112.1 (C-4), 117.4 (C-Coum),126.5 (C-Coum), 127.5, 130.2, 132.6 (C-20, C-30, C-40, C-50C-60), 130.3, 133.9, 135.7 (C-6, 2 C-Coum), 110.5, 118.2,123.9, 124.4, 131.4, 140.1, 145.9, 154.6 (C-3, C-4a, C-5, C-7, C-10, 4 Cq-Coum), 143.9 (C-1), 148.9 (C-Coum), 164.0(CO2Et), 180.4 (CO-Coum) ppm; IR (KBr): v = 1728,1698, 1630, 1613, 1525, 1477, 1355, 1258, 1210 cm-1.

Statistics shows that 3438-48-0 is playing an increasingly important role. we look forward to future research findings about 4-Phenylpyrimidine.

Reference:
Article; Popa, Marcel M.; Georgescu, Emilian; Draghici, Constantin; Georgescu, Florentina; Dumitrascu, Florea; Dumitrescu, Denisa; Monatshefte fur Chemie; vol. 146; 12; (2015); p. 2029 – 2040;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 3438-48-0 ,Some common heterocyclic compound, 3438-48-0, molecular formula is C10H8N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

The intermediate b (10 g, 0.06 mol)Was added to 500 mL of formamide,Stirred at room temperature for 30-60 minutes,After the intermediate b was completely dissolved,Transferred to the cold wells, the temperature control in 10 below,Dropping 20mL of concentrated sulfuric acid,While dropping hydrogen peroxide (50 mL)And aqueous ferrous sulfate heptahydrate solution (100 mL)Drop complete, 10-15 reaction 30min,After the reaction was completed, 2000 mL of water was added,Saturated sodium carbonate aqueous solution adjusted to pH 9,Dichloromethane was extracted three times (200 mL * 3)The combined dichloromethane was washed once with saturated brine,Dry methylene chloride as a white solid 5.7 g, yield 48%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3438-48-0, its application will become more common.

Reference:
Patent; Shenyang Pharmaceutical University; Gong, Ping; Zhao, Yanfang; Liu, Yaijing; Di, Xin; Tang, Qidong; (42 pag.)CN104072480; (2016); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia