Category: 347418-42-2

Related Products of 347418-42-2 ,Some common heterocyclic compound, 347418-42-2, molecular formula is C4H2ClFN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of N-(5-(4-acetylpiperazin- l-yl)pyridin-2-yl)-2-(4-(4,4,5,5- tetramethyl-l,3,2-dioxaborolan-2-yl)phenyl)acetamide 196-1 (30 mg, 0.065 mmol), 4-chloro-5- fluoropyrimidine 196-2 (28 mg, 0.21 mmol) Pd(PPh3)4 (12 mg, 0.01 mmol) and K3PO4 (90 mg, 0.424 mmol) in dioaxane (0.6 mL) was flushed with nitrogen and heated to 110C for 2 hours. The salt was removed by filtration and the filtrate was taken to dryness by rotary evaporation. The residue was purified by reverse phase HPLC to give N-(5-(4-acetylpiperazin-l-yl)pyridin-2- yl)-2-(4-(5-fluoropyrimidin-4-yl)phenyl)acetamide 196. MS m/z 435.10 (M + 1). 1H NMR 400 MHz (DMSO-d6) deltaltheta.54 (s, IH), 9.06 (d, IH), 8.90 (d, IH), 7.98 (m, 3H), 7.86 (d, IH), 7.49 (d, 2H), 7.37 (m, IH), 3.73 (s, 2H), 3.50 (m, 4H), 3.09 (t, 2H), 3.02 (t, 2H), 1.97 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 347418-42-2, 4-Chloro-5-fluoropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; IRM LLC; CHENG, Dai; ZHANG, Guobao; HAN, Dong; GAO, Wenqi; PAN, Shifeng; WO2010/101849; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 347418-42-2, 4-Chloro-5-fluoropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 4-Chloro-5-fluoropyrimidine, blongs to pyrimidines compound. Safety of 4-Chloro-5-fluoropyrimidine

The compound 5 (1 mmol),The compound 4-chloro-5-fluoropyrimidine (1 mmol)Dissolved in NMP (10 mL)CuI (20 mmol%) was added,Pd (PPh3) 2Cl2 (5 mmol%),DIEA (5 mmol).Under nitrogen protection,60 reaction 12h.TCL monitoring reaction is complete,Extracted three times with ethyl acetate,Combine organic phase,Washed twice with saturated NaCl,Anhydrous Na2SO4 dry.Spin dry,Column chromatography gave compound 7r.

The synthetic route of 347418-42-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Second Military Medical University, PLA; Yantai Dongcheng Pharmaceutical Industry Group Co., Ltd.; Zhang, Dazhi; Jiang, Yuanying; Niting, Junhong; Cai, Zhan; Pang, Lei; Xie, Fei; Li, Ran; Han, Haibing; He, Yan; You, Shouyi; Yang, Zhenqiu; Qi, Dongqi; (36 pag.)CN106336383; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 347418-42-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 347418-42-2, name is 4-Chloro-5-fluoropyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

2,4-Dichloro-5-fluoropyrimidine (7, 0.37 g, 2.2 mmol), sodium carbonate (0.42 g, 4 mmol) dissolved in 1,4-dioxane/water (10 mL / 2 mL) Add bistriphenylphosphine palladium dichloride (Pd(PPh3)2Cl2, 0.033g, 0.048 mmol) under nitrogen, heat to 80 C, add 1-isopropyl-4-fluoro-6-borate A solution of the alcohol ester-1H-carbazole (6a, 0.5 g, 1.6 mmol) in 1,4-dioxane (10 mL). The reaction 80 4 hours, the reaction was cooled to room temperature, poured into ice water (50 mL), the precipitated white solid was filtered to give the residue, recrystallized from isopropanol, to give a white solid 8a (0.4 g, 81%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 347418-42-2, 4-Chloro-5-fluoropyrimidine.

Reference:
Patent; Hangzhou Bai Cheng Pharmaceutical Technology Co., Ltd.; Sheng Rong; Lou Jinfang; Zhang Fengmin; Luo Jin; Wu Lijun; Yang Huan; Jin Zewu; Xiong Xiaohong; Qian Yang; (32 pag.)CN110156754; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 347418-42-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 347418-42-2 as follows.

Step 2 17.5 g Sodium hydride (60% dispersion in mineral oil) was suspended in300 ml N,N-dimethylformamide. The reaction mixture was cooled with an ice- water bath. 70.0 ml Diethyl malonate was added dropwise over 45 minutes. The resulting clear mixture was stirred at ambient temperature for 30 minutes. 36.2 g Crude product from the preceded step was added dropwise over 20 minutes at ambient temperature. The orange reaction mixture was stirred at ambient temperature. Reaction progress was monitored with HPLC. After 18 hours, the reaction mixture was concentrated in vacuo to remove most of the N,N- dimethylformamide.300 ml diethyl ether and100 ml water were added and the mixture was stirred vigorously for 5 minutes. The pH of the mixture was adjusted to ~7 with aqueous hydrochloric acid (1.5 M). The layers were separated and150 ml diethyl ether was added to the aqueous layer. The pH was again adjusted to ~7. The combined organic layers were washed with300 ml brine, dried (Na2S04) and concentrated in vacuo. The obtained yellow oily liquid contained still some mineral oil (floating on top). Most of the mineral oil was removed by using a separation funnel. The excess of diethyl malonate still present was removed by vacuum distillation (80C, 0.65 mbar). The product diethyl (5- fluoro-4-pyrimidinyl)malonate was isolated as a yellow oily liquid (89.6% purity acc. HPLC, NMR confirms expected structure) that was used directly in the next step.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,347418-42-2, its application will become more common.

Reference:
Patent; SYNTHRON B.V.; OVEREEM, Arjanne; ZHU, Jie; WO2011/110198; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 347418-42-2, 4-Chloro-5-fluoropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 347418-42-2, blongs to pyrimidines compound. Recommanded Product: 347418-42-2

Pd(Ph3P)4 (43.6 mg, 0.038 mmol) and 1,1,1,2,2,2-hexamethyldistannane (124 mg, 0.377 mmol) were successively added to a mixture of 4-chloro-5-fluoropyrimidine (50 g, 0.377 mmol) in 1,4-dioxane (1886 mE) under a nitrogen atmosphere. The reaction mixture was then stirred at reflux overnight, cooled to r.t, and filtered. The filtrate was used in next step without further purification.

The synthetic route of 347418-42-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; INCYTE CORPORATION; WANG, Xiaozhao; GAN, Pei; HAN, Heeoon; HUANG, Taisheng; MCCAMMANT, Matthew S.; QI, Chao; QIAN, Ding-Quan; WU, Liangxing; YAO, Wenqing; YU, Zhiyong; ZHANG, Fenglei; (284 pag.)WO2019/168847; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.347418-42-2, name is 4-Chloro-5-fluoropyrimidine, molecular formula is C4H2ClFN2, molecular weight is 132.52, as common compound, the synthetic route is as follows.Application In Synthesis of 4-Chloro-5-fluoropyrimidine

1) Pyridinium chlorochromate,Sodium ferrate,Phosphoric acid and tetrabutylammonium chloride are added to the water,Pass argon as a protective gas,Then heated to 120 C as reactant A;Dissolving 4-chloro-5-fluoropyrimidine in DMSO as reactant B;Maintain 120 C and protective gas conditions,Passing reactant A to drop B into A,Control the dropping time to 60min,After the completion of the dropwise addition, the system was further heated to 140 C.The reaction was completed at 4.5 h.The ratio of each material in the reaction is 4-chloro-5-fluoropyrimidine,Chlorination reagent,Ferrate,The ratio of acid to quaternary ammonium salt is 1:1.04:1.16:0.009:0.014;4-chloro-5-fluoropyrimidine and water,The amount ratio of disulfoxide was: 1 mmol: 2.2 ml: 1.4 ml.2) After cooling the system, the solid is removed by filtration.Then extracted with ethyl acetate,After washing and concentrating, a crude product is obtained.Decompression distillation gives a pure product,The yield was 97.5%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,347418-42-2, 4-Chloro-5-fluoropyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Shandong Nong Pharmaceutical Xue Institute; Jinan Kehai Co., Ltd.; Fu Hongxin; Yang Chaohui; Wang Ling; (5 pag.)CN108997222; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 347418-42-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 347418-42-2 as follows.

Step 1 To a solution of A16 (25 mg, 0.056 mmol) and 4-chloro-5-fluoropyrimidine (15 mg, 0.11 mmol) in DMSO (0.5 mL) was added CS2CO3 (37 mg, 0.11 mmol) and the mixture was stirred at 15C for 35 mins. The mixture was quenched with water (15 mL) and extracted with EtOAc (4 x 25 mL). The combined organic extracts were washed with brine (10 mL), dried over Na2S04, filtered and concentrated to provide CI as brown oil which was used in the next step without further purification. MS for CI m/e = 540.2 (M+l).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,347418-42-2, its application will become more common.

Reference:
Patent; MERCK SHARP & DOHME CORP.; WALSH, Shawn, P.; CUMMING, Jared, N.; DAI, Xing; (84 pag.)WO2017/139210; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia