Category: 35139-67-4

Product class 12: pyrimidines was written by von Angerer, S.. And the article was included in Science of Synthesis in 2004.Quality Control of 2,6-Diamino-4-chloropyrimidine-1-oxide The following contents are mentioned in the article:

A review. Methods for preparing pyrimidines are reviewed including cyclization, ring transformation, aromatization and substituent modification. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Quality Control of 2,6-Diamino-4-chloropyrimidine-1-oxide).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Quality Control of 2,6-Diamino-4-chloropyrimidine-1-oxide

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

Pyrimidine N-oxides. VI. The ionization constants of pyrimidine-2,4-diamine N-oxides was written by Cowden, William B.; Jacobsen, Noel W.. And the article was included in Australian Journal of Chemistry in 1984.Application of 35139-67-4 The following contents are mentioned in the article:

The ionization constants of some pyrimidine-2,4-diamines and their N-oxides, including the drugs trimethoprim and minoxidil, are reported. The syntheses of several pyrimidine-2,4-diamine N-oxides are described. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Application of 35139-67-4).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Application of 35139-67-4

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

Can nitrogen-15 NMR be used to determine the site of N-oxidation of pyrimidine-2,4-diamine? was written by Cowden, William B.; Waring, Paul. And the article was included in Australian Journal of Chemistry in 1981.HPLC of Formula: 35139-67-4 The following contents are mentioned in the article:

An examination of the products of N-oxidation of pyrimidine-2,4-diamine demonstrated that 15N spectroscopy is an unreliable technique for the determination of the site of N-oxidation The 15N shifts caused by N-oxidation were small and downfield and of no diagnostic value. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4HPLC of Formula: 35139-67-4).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.HPLC of Formula: 35139-67-4

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

Heterocyclic N-oxide reduction by titanium trichloride was written by McCall, John M.; TenBrink, Ruth E.. And the article was included in Synthesis in 1975.Electric Literature of C4H5ClN4O The following contents are mentioned in the article:

2,4-Diamino-6-piperidinopyrimidine 3-oxide was treated with 20% aqueous TiCl3 in MeOH at 0° to give 97% 2,4-diamino-6-piperidinopyrimidine. Similarly reduced were 2,4-diamino-6-chloropyrimidine 3-oxide, 3-picoline oxide, 2-amino-4-methylquinazoline 3-oxide, and 4-chloro-2-methylpyridine oxide. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Electric Literature of C4H5ClN4O).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Electric Literature of C4H5ClN4O

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

Synthesis of 2,4-diamino-6-piperidinylpyrimidine-3-oxide-3′,4′,5′-3H(N) tritiated minoxidil was written by Gilbertson, Terry J.. And the article was included in Journal of Labelled Compounds and Radiopharmaceuticals in 1976.Electric Literature of C4H5ClN4O The following contents are mentioned in the article:

Minoxidil-3′,4′,5′-3H(N), 25.6 Ci/mM, was prepared by reaction of piperidine-3,4,5-3H(N) with 2,4-diamino-6-chloropyrimidine 3-oxide in a sealed tube at 80-90° in the presence of concentrated NH4OH. Purification was by paper chromatog. and the product was suitable for radioimmunoassay and was stable for 6 months in MeOH at 4°. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Electric Literature of C4H5ClN4O).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Electric Literature of C4H5ClN4O

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

Pyrimidine N-oxide. Preparation of 6-chloro-2,4-diaminopyrimidine 3-N-oxide and its reactions was written by Delia, Thomas J.; Venton, Duane L.. And the article was included in Journal of Heterocyclic Chemistry in 1972.Reference of 35139-67-4 The following contents are mentioned in the article:

The peroxyacid oxidation of 6-chloro-2,4-diaminopyrimidine gave 6-chloro-2,4-diaminopyrimidine 3-oxide and 2,4-diamino-5,6-dichloropyrimidine 3-oxide (I). The assignment of structure of both of these compounds was made on the basis of ir, uv, NMR, and mass spectral data. A discussion of the pathways involved in the formation of I is presented. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Reference of 35139-67-4).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Reference of 35139-67-4

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

Regioselective synthesis of 2-oxo-2,8-dihydro-[1,2,4]oxadiazolo[2,3-a]pyrimidine-7-carbamates: a new class of antihypertensive peripheral vasodilators was written by Muller, Jean Claude; Ramuz, Henri. And the article was included in Helvetica Chimica Acta in 1982.Formula: C4H5ClN4O The following contents are mentioned in the article:

Oxadiazolopyrimidinecarbamates I (R = Me, Et, Bu, CH2CHMe2, CH2Ph, CH2CH2OMe) were prepared by oxidizing 6-chloro-2,4-pyrimidinediamine to give 3-oxide and reaction with tetrahydropyridine to give II (R1 = H). Treatment of II (R1 = H) with RO2CCl gave II (R1 = CO2R) which cyclized to I on heating. I, especially I (R = Me), have antihypertensive activity. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Formula: C4H5ClN4O).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Formula: C4H5ClN4O

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

Metabolic N-oxygenation of 2,4-diamino-6-substituted pyrimidines was written by El-Ghomari, K.; Gorrod, J. W.. And the article was included in European Journal of Drug Metabolism and Pharmacokinetics in 1987.Category: pyrimidines The following contents are mentioned in the article:

Biol. oxidation of 2,4-diamino-6-substituted pyrimidines was studied using hepatic microsomes from various mammalian species. The 3-N-oxides were formed with 6-pipeidino-, 6-diethylamino-, 6-methyl-, and 6-chloro-substituted 2,4-diaminopyrimidines: no evidence of 1-N-oxide formation was obtained. With the 6-hydroxy-, 6-amino-, and unsubstituted 2,4-diaminopyrimidines and melamine, no N-oxidative metabolite was detected. The differences in N-oxide formation is discussed in terms of the effect of substituents on tautomerism and electron distribution. The N-oxygenation was mediated via a cytochrome P 450-dependent system. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Category: pyrimidines).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Category: pyrimidines

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

The promoted synthesis of minoxidil by magnetic nanoparticles of cobalt ferrite (CoFe2 O4) as a heterogeneous reusable catalyst was written by Eisavi, Ronak; Ahmadi, Fatemeh; Zeynizadeh, Behzad; Kouhkan, Mehri. And the article was included in Turkish Journal of Chemistry in 2019.Related Products of 35139-67-4 The following contents are mentioned in the article:

Minoxidil (2,4-diamino-6-piperidinopyrimidine 3-oxide) was primarily recognized as a drug for reducing vascular resistance to blood flow. It was later introduced as a more important medicine for topical stimulation of hair growth and baldness reverting as well as treatment of androgenic alopecia through increasing prostaglandin endoperoxide synthesis. In this study, magnetic nanoparticles (MNPs) of spinel ferrites (MFe2 O4, M = Co, Ni, Fe, Cu, and Zn) via solid-state grinding procedure were prepared and then characterized using X-ray diffraction, SEM, transmission electron microscopy, vibrating sample magnetometer, and Fourier transform IR techniques. The prepared nanoferrites were utilized as efficient and green heterogeneous catalysts for N -oxidation of 2,6-diamino-4-chloro-pyrimidine with H2 O2 in refluxing ethanol giving 2,6-diamino-4-chloro-pyrimidine N -oxide as a starting material for the synthesis of 2,4-diamino-6-piperidinopyrimidine 3-oxide (minoxidil). Among the examined nanoferrites, CoFe2 O4 MNPs exhibited prominent catalytic activity giving the product in 95% yield within 60 min. Moreover, the reusability of nano-CoFe2 O4 was examined for 6 consecutive cycles without significant loss of catalytic activity and magnetic property. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Related Products of 35139-67-4).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Related Products of 35139-67-4

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

Metabolism of minoxidil, a new hypotensive agent. II. Biotransformation following oral administration to rats, dogs, and monkeys was written by Thomas, Richard C.; Harpootlian, Harry. And the article was included in Journal of Pharmaceutical Sciences in 1975.Application In Synthesis of 2,6-Diamino-4-chloropyrimidine-1-oxide The following contents are mentioned in the article:

The biotransformation of minoxidil (I) [38304-91-5] was studied in the rat, dog, and monkey and compared to reported results in the human. Each species excreted substantially the same metabolites, but in quite different relative amounts The monkey and the human exhibited similar metabolite profiles, whereas the dog and rat were quant. different from each other and from the monkey and human. The major excretory product for the monkey and human was I glucuronide [56828-40-1]. Substantially smaller amounts of unchanged I, 2,4-diamino-6-(4′-hydroxypiperidino)pyrimidine 3-oxide [56828-37-6], and more polar metabolites also were excreted by these 2 species. The major excretory product in the rat was unchanged I. Almost as much (combined) of the 2 acidic metabolites, 2,4-diamino-6-(4′-carboxy-n-butylamino)pyrimidine [56828-38-7] and its 3-oxide [56828-41-2], also were produced. Smaller amounts of the glucuronide of I, 2,4-diamino-6-(4′-hydroxypiperidino)pyrimidine 3-oxide, its 3′-hydroxy isomer [56828-39-8], and 2,4-diamino-6-piperidinopyrimidine [24867-26-3] also were excreted by the rat. The major metabolite of I excreted by the dog was the 4′-hydroxy metabolite. Smaller amounts of unchanged I and polar metabolites and much smaller amounts of the glucuronide of I, the 3′-hydroxy metabolite, and 2,4-diamino-6-piperidinopyrimidine also were excreted by the dog. Evidence was obtained for a 4′-hydroxy metabolite glucuronide in this species. The major circulatory material in dog plasma was the 4′-hydroxy metabolite, whereas it was the glucuronide of I in monkey plasma. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Application In Synthesis of 2,6-Diamino-4-chloropyrimidine-1-oxide).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Application In Synthesis of 2,6-Diamino-4-chloropyrimidine-1-oxide

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4