Category: 35139-67-4

2,4-Diamino-6-piperidinyl- and 6-piperazinylpyrimidine 3-oxides, new analogs of minoxidil was written by Catto, A.; Lo Verde, G.; Luca, C.; Graziani, G.; Nardi, D.; Casadio, S.. And the article was included in Bollettino Chimico Farmaceutico on January 31,1982.HPLC of Formula: 35139-67-4 The following contents are mentioned in the article:

Title compounds [I; R = Ph, 1-substituted 4-piperidinyl, 1-piperidinyl, CONH2, PhCONH; R1 = OH, H; and RR1 = (CH2)5, SCH2CH2S, OZO (Z = linear or branched alkylene)] and (II; R2 = H, Me, substituted pyrimidinyl, 2-MeOC6H4, 3-ClC6H4, 2-pyridyl) were prepared from 6-chloro-2,4-pyrimidinediamine 3-oxide (III) and III·3-ClC6H4CO2H; I and II exhibited antihypertensive activity. III was treated with 4-phenyl-4-piperidinol to give I (R = Ph, R1 = OH). This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4HPLC of Formula: 35139-67-4).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.HPLC of Formula: 35139-67-4

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

An improved procedure for the preparation of aromatic heterocyclic N-oxides was written by Rhie, Soo Young; Ryu, Eung K.. And the article was included in Heterocycles on February 1,1995.Reference of 35139-67-4 The following contents are mentioned in the article:

Nitrogen-containing heterocyclic compounds gave their N-oxides in excellent yields by reaction with m-chloroperbenzoic acid in DMF/MeOH in the presence of HF. The presence of HF and MeOH is crucial for the reaction. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Reference of 35139-67-4).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Reference of 35139-67-4

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

Supramolecular interactions in 2,6-diamino-4-chloropyrimidin-1-ium 5-chlorosalicylate and bis(2,6-diamino-4-chloropyrimidin-1-ium) naphthalene-1,5-disulfonate was written by Swinton Darious, Robert; Thomas Muthiah, Packianathan; Perdih, Franc. And the article was included in Acta Crystallographica, Section E: Crystallographic Communications on February 1,2018.Application of 35139-67-4 The following contents are mentioned in the article:

The crystals of two new salts, 2,6-diamino-4-chloropyrimidin-1-ium 5-chlorosalicylate, C4H6ClN4+·C7H4ClO3-, (I), and bis(2,6-diamino-4-chloropyrimidin-1-ium) naphthalene-1,5-di-sulfonate, 2C4H6ClN4+·C10H6O6S22-, (II), have been synthesized and characterized by single-crystal X-ray diffraction. In both compounds, the N atom of the pyrimidine group in between the amino substituents is protonated and the pyrimidinium cation forms a pair of N-H···O hydrogen bonds with the carboxylate/sulfonate ion, leading to a robust R22(8) motif (supramol. heterosynthon). In compound (I), a self-complementary base pairing involving the other pyrimidinium ring nitrogen atom and one of the amino groups via a pair of N-H···N hydrogen bonds [R22(8) homosynthon] is also present. In compound (II), the crystallog. inversion center coincides with the inversion center of the naphthalene-1,5-disulfonate ion and all the sulfonate O atoms are hydrogen-bond acceptors, generating fused-ring motifs and a quadruple DDAA array. A halogen-bond (Cl···Cl) interaction is present in (I) with a distance and angle of 3.3505 (12) Å and 151.37 (10)°, resp. In addition, a C-Cl···π interaction and a π-π interaction in (I) and a π-π interaction in (II) further stabilize these crystal structures. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Application of 35139-67-4).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Application of 35139-67-4

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

Relative Reactivity in Piperidino-Dechlorination of 2,4-Diamino-6-chloropyrimidine and 2,4-Diamino-6-chloropyrimidine N(3)-Oxide and Their Acetylamino Analogs was written by Maltese, M.. And the article was included in Journal of Organic Chemistry on April 21,1995.Name: 2,6-Diamino-4-chloropyrimidine-1-oxide The following contents are mentioned in the article:

The second-order rate constants kA for the piperidino-dechlorination of 2,4-diamino-6-chloropyrimidine (1a), 2,4-bis(acetylamino)-6-chloropyrimidine (1b), 2,4-diamino-6-chloropyrimidine N(3)-oxide (2a), and 2,4-bis(acetylamino)-6-chloropyrimidine N(3)-oxide (2b) have been determined from the corresponding pseudo-first-order rate constants, kψ, measured in DMSO at 21.0 °C by the UV spectrophotometric procedure. The second-order rate coefficients of the less reactive substrates 1a and 2a at 21 °C have been obtained as extrapolated values from Arrhenius plots of kA values, calculated through the pseudo-first-order-type relationship, kψ = kA[P] (where [P] is the amine concentration), from the kψ measured at higher temperatures (kA(1a) = 1.36 × 10-5 and kA(2a) = 3.44 × 10-5 L mol-1 min-1). The reactivities of the acetyl derivatives 1b and 2b are remarkably higher than that of the parent compounds 1a and 2a. The pseudo-first-order rate constants of the more reactive substrates 1b and 2b, measured as a function of piperidine concentration, increase linearly for 1b, with a decreasing curvilinear slope only in the higher concentration region of base; in contrast, the reactivity of 2b remains almost constant and lower than that of 1b for most of the employed base concentrations This behavior is due to the acidic character of compound 2b, which is almost totally transformed by excess piperidine into an anionic form, much less reactive than the protonated one toward the nucleophilic attack, even at relatively low base concentrations Compound 1b is much less acidic than 2b and shows deviations from the second-order-type linear behavior only for the higher base concentrations The equilibrium constant for the acid-base reaction of 2b with piperidine has been obtained spectrophotometrically (K = 0.007 ± 0.001), and the second-order rate coefficient kA has been calculated from the constant apparent reactivity k by means of the formula kA = kψ[PH+]/K (where [PH+] is the piperidinium ion concentration) (kA(2b) = 2.7 L mol-1 min-1). That of 1b is given by the slope of the exptl. curve kψ vs [P] in the proximity of the origin (kA(1b) = 0.15 L mol-1 min-1). The results indicate that both the acetylation of the exocyclic -NH2 groups and the oxidation of the cyclic N(3)-atom increase the reactivity of the parent compounds toward piperidinolysis, but that the first modification is much more effective than the second one. The dependence of kψ of 1b and 2b on the amine concentration does not give any evidence for base catalysis, as expected in the model of the intermediate complex mechanism when the leaving group is fast to sep. (as the -Cl group is) and/or the complex formation is rate-limiting. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Name: 2,6-Diamino-4-chloropyrimidine-1-oxide).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Name: 2,6-Diamino-4-chloropyrimidine-1-oxide

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

Product class 12: pyrimidines was written by von Angerer, S.. And the article was included in Science of Synthesis in 2004.Quality Control of 2,6-Diamino-4-chloropyrimidine-1-oxide The following contents are mentioned in the article:

A review. Methods for preparing pyrimidines are reviewed including cyclization, ring transformation, aromatization and substituent modification. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Quality Control of 2,6-Diamino-4-chloropyrimidine-1-oxide).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Quality Control of 2,6-Diamino-4-chloropyrimidine-1-oxide

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

Pyrimidine N-oxides. VI. The ionization constants of pyrimidine-2,4-diamine N-oxides was written by Cowden, William B.; Jacobsen, Noel W.. And the article was included in Australian Journal of Chemistry in 1984.Application of 35139-67-4 The following contents are mentioned in the article:

The ionization constants of some pyrimidine-2,4-diamines and their N-oxides, including the drugs trimethoprim and minoxidil, are reported. The syntheses of several pyrimidine-2,4-diamine N-oxides are described. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Application of 35139-67-4).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Application of 35139-67-4

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

Can nitrogen-15 NMR be used to determine the site of N-oxidation of pyrimidine-2,4-diamine? was written by Cowden, William B.; Waring, Paul. And the article was included in Australian Journal of Chemistry in 1981.HPLC of Formula: 35139-67-4 The following contents are mentioned in the article:

An examination of the products of N-oxidation of pyrimidine-2,4-diamine demonstrated that 15N spectroscopy is an unreliable technique for the determination of the site of N-oxidation The 15N shifts caused by N-oxidation were small and downfield and of no diagnostic value. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4HPLC of Formula: 35139-67-4).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.HPLC of Formula: 35139-67-4

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

Heterocyclic N-oxide reduction by titanium trichloride was written by McCall, John M.; TenBrink, Ruth E.. And the article was included in Synthesis in 1975.Electric Literature of C4H5ClN4O The following contents are mentioned in the article:

2,4-Diamino-6-piperidinopyrimidine 3-oxide was treated with 20% aqueous TiCl3 in MeOH at 0° to give 97% 2,4-diamino-6-piperidinopyrimidine. Similarly reduced were 2,4-diamino-6-chloropyrimidine 3-oxide, 3-picoline oxide, 2-amino-4-methylquinazoline 3-oxide, and 4-chloro-2-methylpyridine oxide. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Electric Literature of C4H5ClN4O).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Electric Literature of C4H5ClN4O

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

Synthesis of 2,4-diamino-6-piperidinylpyrimidine-3-oxide-3′,4′,5′-3H(N) tritiated minoxidil was written by Gilbertson, Terry J.. And the article was included in Journal of Labelled Compounds and Radiopharmaceuticals in 1976.Electric Literature of C4H5ClN4O The following contents are mentioned in the article:

Minoxidil-3′,4′,5′-3H(N), 25.6 Ci/mM, was prepared by reaction of piperidine-3,4,5-3H(N) with 2,4-diamino-6-chloropyrimidine 3-oxide in a sealed tube at 80-90° in the presence of concentrated NH4OH. Purification was by paper chromatog. and the product was suitable for radioimmunoassay and was stable for 6 months in MeOH at 4°. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Electric Literature of C4H5ClN4O).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Electric Literature of C4H5ClN4O

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

Pyrimidine N-oxide. Preparation of 6-chloro-2,4-diaminopyrimidine 3-N-oxide and its reactions was written by Delia, Thomas J.; Venton, Duane L.. And the article was included in Journal of Heterocyclic Chemistry in 1972.Reference of 35139-67-4 The following contents are mentioned in the article:

The peroxyacid oxidation of 6-chloro-2,4-diaminopyrimidine gave 6-chloro-2,4-diaminopyrimidine 3-oxide and 2,4-diamino-5,6-dichloropyrimidine 3-oxide (I). The assignment of structure of both of these compounds was made on the basis of ir, uv, NMR, and mass spectral data. A discussion of the pathways involved in the formation of I is presented. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Reference of 35139-67-4).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Reference of 35139-67-4

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4