Category: 35139-67-4

Regioselective synthesis of 2-oxo-2,8-dihydro-[1,2,4]oxadiazolo[2,3-a]pyrimidine-7-carbamates: a new class of antihypertensive peripheral vasodilators was written by Muller, Jean Claude; Ramuz, Henri. And the article was included in Helvetica Chimica Acta in 1982.Formula: C4H5ClN4O The following contents are mentioned in the article:

Oxadiazolopyrimidinecarbamates I (R = Me, Et, Bu, CH2CHMe2, CH2Ph, CH2CH2OMe) were prepared by oxidizing 6-chloro-2,4-pyrimidinediamine to give 3-oxide and reaction with tetrahydropyridine to give II (R1 = H). Treatment of II (R1 = H) with RO2CCl gave II (R1 = CO2R) which cyclized to I on heating. I, especially I (R = Me), have antihypertensive activity. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Formula: C4H5ClN4O).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Formula: C4H5ClN4O

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

Metabolic N-oxygenation of 2,4-diamino-6-substituted pyrimidines was written by El-Ghomari, K.; Gorrod, J. W.. And the article was included in European Journal of Drug Metabolism and Pharmacokinetics in 1987.Category: pyrimidines The following contents are mentioned in the article:

Biol. oxidation of 2,4-diamino-6-substituted pyrimidines was studied using hepatic microsomes from various mammalian species. The 3-N-oxides were formed with 6-pipeidino-, 6-diethylamino-, 6-methyl-, and 6-chloro-substituted 2,4-diaminopyrimidines: no evidence of 1-N-oxide formation was obtained. With the 6-hydroxy-, 6-amino-, and unsubstituted 2,4-diaminopyrimidines and melamine, no N-oxidative metabolite was detected. The differences in N-oxide formation is discussed in terms of the effect of substituents on tautomerism and electron distribution. The N-oxygenation was mediated via a cytochrome P 450-dependent system. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Category: pyrimidines).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Category: pyrimidines

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

The promoted synthesis of minoxidil by magnetic nanoparticles of cobalt ferrite (CoFe2 O4) as a heterogeneous reusable catalyst was written by Eisavi, Ronak; Ahmadi, Fatemeh; Zeynizadeh, Behzad; Kouhkan, Mehri. And the article was included in Turkish Journal of Chemistry in 2019.Related Products of 35139-67-4 The following contents are mentioned in the article:

Minoxidil (2,4-diamino-6-piperidinopyrimidine 3-oxide) was primarily recognized as a drug for reducing vascular resistance to blood flow. It was later introduced as a more important medicine for topical stimulation of hair growth and baldness reverting as well as treatment of androgenic alopecia through increasing prostaglandin endoperoxide synthesis. In this study, magnetic nanoparticles (MNPs) of spinel ferrites (MFe2 O4, M = Co, Ni, Fe, Cu, and Zn) via solid-state grinding procedure were prepared and then characterized using X-ray diffraction, SEM, transmission electron microscopy, vibrating sample magnetometer, and Fourier transform IR techniques. The prepared nanoferrites were utilized as efficient and green heterogeneous catalysts for N -oxidation of 2,6-diamino-4-chloro-pyrimidine with H2 O2 in refluxing ethanol giving 2,6-diamino-4-chloro-pyrimidine N -oxide as a starting material for the synthesis of 2,4-diamino-6-piperidinopyrimidine 3-oxide (minoxidil). Among the examined nanoferrites, CoFe2 O4 MNPs exhibited prominent catalytic activity giving the product in 95% yield within 60 min. Moreover, the reusability of nano-CoFe2 O4 was examined for 6 consecutive cycles without significant loss of catalytic activity and magnetic property. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Related Products of 35139-67-4).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Related Products of 35139-67-4

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

Metabolism of minoxidil, a new hypotensive agent. II. Biotransformation following oral administration to rats, dogs, and monkeys was written by Thomas, Richard C.; Harpootlian, Harry. And the article was included in Journal of Pharmaceutical Sciences in 1975.Application In Synthesis of 2,6-Diamino-4-chloropyrimidine-1-oxide The following contents are mentioned in the article:

The biotransformation of minoxidil (I) [38304-91-5] was studied in the rat, dog, and monkey and compared to reported results in the human. Each species excreted substantially the same metabolites, but in quite different relative amounts The monkey and the human exhibited similar metabolite profiles, whereas the dog and rat were quant. different from each other and from the monkey and human. The major excretory product for the monkey and human was I glucuronide [56828-40-1]. Substantially smaller amounts of unchanged I, 2,4-diamino-6-(4′-hydroxypiperidino)pyrimidine 3-oxide [56828-37-6], and more polar metabolites also were excreted by these 2 species. The major excretory product in the rat was unchanged I. Almost as much (combined) of the 2 acidic metabolites, 2,4-diamino-6-(4′-carboxy-n-butylamino)pyrimidine [56828-38-7] and its 3-oxide [56828-41-2], also were produced. Smaller amounts of the glucuronide of I, 2,4-diamino-6-(4′-hydroxypiperidino)pyrimidine 3-oxide, its 3′-hydroxy isomer [56828-39-8], and 2,4-diamino-6-piperidinopyrimidine [24867-26-3] also were excreted by the rat. The major metabolite of I excreted by the dog was the 4′-hydroxy metabolite. Smaller amounts of unchanged I and polar metabolites and much smaller amounts of the glucuronide of I, the 3′-hydroxy metabolite, and 2,4-diamino-6-piperidinopyrimidine also were excreted by the dog. Evidence was obtained for a 4′-hydroxy metabolite glucuronide in this species. The major circulatory material in dog plasma was the 4′-hydroxy metabolite, whereas it was the glucuronide of I in monkey plasma. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Application In Synthesis of 2,6-Diamino-4-chloropyrimidine-1-oxide).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Application In Synthesis of 2,6-Diamino-4-chloropyrimidine-1-oxide

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

An improved procedure for the preparation of aromatic heterocyclic N-oxides was written by Rhie, Soo Young; Ryu, Eung K.. And the article was included in Heterocycles on February 1,1995.Reference of 35139-67-4 The following contents are mentioned in the article:

Nitrogen-containing heterocyclic compounds gave their N-oxides in excellent yields by reaction with m-chloroperbenzoic acid in DMF/MeOH in the presence of HF. The presence of HF and MeOH is crucial for the reaction. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Reference of 35139-67-4).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Reference of 35139-67-4

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

Supramolecular interactions in 2,6-diamino-4-chloropyrimidin-1-ium 5-chlorosalicylate and bis(2,6-diamino-4-chloropyrimidin-1-ium) naphthalene-1,5-disulfonate was written by Swinton Darious, Robert; Thomas Muthiah, Packianathan; Perdih, Franc. And the article was included in Acta Crystallographica, Section E: Crystallographic Communications on February 1,2018.Application of 35139-67-4 The following contents are mentioned in the article:

The crystals of two new salts, 2,6-diamino-4-chloropyrimidin-1-ium 5-chlorosalicylate, C4H6ClN4+·C7H4ClO3-, (I), and bis(2,6-diamino-4-chloropyrimidin-1-ium) naphthalene-1,5-di-sulfonate, 2C4H6ClN4+·C10H6O6S22-, (II), have been synthesized and characterized by single-crystal X-ray diffraction. In both compounds, the N atom of the pyrimidine group in between the amino substituents is protonated and the pyrimidinium cation forms a pair of N-H···O hydrogen bonds with the carboxylate/sulfonate ion, leading to a robust R22(8) motif (supramol. heterosynthon). In compound (I), a self-complementary base pairing involving the other pyrimidinium ring nitrogen atom and one of the amino groups via a pair of N-H···N hydrogen bonds [R22(8) homosynthon] is also present. In compound (II), the crystallog. inversion center coincides with the inversion center of the naphthalene-1,5-disulfonate ion and all the sulfonate O atoms are hydrogen-bond acceptors, generating fused-ring motifs and a quadruple DDAA array. A halogen-bond (Cl···Cl) interaction is present in (I) with a distance and angle of 3.3505 (12) Å and 151.37 (10)°, resp. In addition, a C-Cl···π interaction and a π-π interaction in (I) and a π-π interaction in (II) further stabilize these crystal structures. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Application of 35139-67-4).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Application of 35139-67-4

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

2,4-Diamino-6-piperidinyl- and 6-piperazinylpyrimidine 3-oxides, new analogs of minoxidil was written by Catto, A.; Lo Verde, G.; Luca, C.; Graziani, G.; Nardi, D.; Casadio, S.. And the article was included in Bollettino Chimico Farmaceutico on January 31,1982.HPLC of Formula: 35139-67-4 The following contents are mentioned in the article:

Title compounds [I; R = Ph, 1-substituted 4-piperidinyl, 1-piperidinyl, CONH2, PhCONH; R1 = OH, H; and RR1 = (CH2)5, SCH2CH2S, OZO (Z = linear or branched alkylene)] and (II; R2 = H, Me, substituted pyrimidinyl, 2-MeOC6H4, 3-ClC6H4, 2-pyridyl) were prepared from 6-chloro-2,4-pyrimidinediamine 3-oxide (III) and III·3-ClC6H4CO2H; I and II exhibited antihypertensive activity. III was treated with 4-phenyl-4-piperidinol to give I (R = Ph, R1 = OH). This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4HPLC of Formula: 35139-67-4).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.HPLC of Formula: 35139-67-4

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

Relative Reactivity in Piperidino-Dechlorination of 2,4-Diamino-6-chloropyrimidine and 2,4-Diamino-6-chloropyrimidine N(3)-Oxide and Their Acetylamino Analogs was written by Maltese, M.. And the article was included in Journal of Organic Chemistry on April 21,1995.Name: 2,6-Diamino-4-chloropyrimidine-1-oxide The following contents are mentioned in the article:

The second-order rate constants kA for the piperidino-dechlorination of 2,4-diamino-6-chloropyrimidine (1a), 2,4-bis(acetylamino)-6-chloropyrimidine (1b), 2,4-diamino-6-chloropyrimidine N(3)-oxide (2a), and 2,4-bis(acetylamino)-6-chloropyrimidine N(3)-oxide (2b) have been determined from the corresponding pseudo-first-order rate constants, kψ, measured in DMSO at 21.0 °C by the UV spectrophotometric procedure. The second-order rate coefficients of the less reactive substrates 1a and 2a at 21 °C have been obtained as extrapolated values from Arrhenius plots of kA values, calculated through the pseudo-first-order-type relationship, kψ = kA[P] (where [P] is the amine concentration), from the kψ measured at higher temperatures (kA(1a) = 1.36 × 10-5 and kA(2a) = 3.44 × 10-5 L mol-1 min-1). The reactivities of the acetyl derivatives 1b and 2b are remarkably higher than that of the parent compounds 1a and 2a. The pseudo-first-order rate constants of the more reactive substrates 1b and 2b, measured as a function of piperidine concentration, increase linearly for 1b, with a decreasing curvilinear slope only in the higher concentration region of base; in contrast, the reactivity of 2b remains almost constant and lower than that of 1b for most of the employed base concentrations This behavior is due to the acidic character of compound 2b, which is almost totally transformed by excess piperidine into an anionic form, much less reactive than the protonated one toward the nucleophilic attack, even at relatively low base concentrations Compound 1b is much less acidic than 2b and shows deviations from the second-order-type linear behavior only for the higher base concentrations The equilibrium constant for the acid-base reaction of 2b with piperidine has been obtained spectrophotometrically (K = 0.007 ± 0.001), and the second-order rate coefficient kA has been calculated from the constant apparent reactivity k by means of the formula kA = kψ[PH+]/K (where [PH+] is the piperidinium ion concentration) (kA(2b) = 2.7 L mol-1 min-1). That of 1b is given by the slope of the exptl. curve kψ vs [P] in the proximity of the origin (kA(1b) = 0.15 L mol-1 min-1). The results indicate that both the acetylation of the exocyclic -NH2 groups and the oxidation of the cyclic N(3)-atom increase the reactivity of the parent compounds toward piperidinolysis, but that the first modification is much more effective than the second one. The dependence of kψ of 1b and 2b on the amine concentration does not give any evidence for base catalysis, as expected in the model of the intermediate complex mechanism when the leaving group is fast to sep. (as the -Cl group is) and/or the complex formation is rate-limiting. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Name: 2,6-Diamino-4-chloropyrimidine-1-oxide).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Name: 2,6-Diamino-4-chloropyrimidine-1-oxide

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

Separation of minoxidil and its intermediates by overpressured layer chromatography using a stationary phase bonded with tricaprylmethylammonium chloride was written by Kovacs-Hadady, Katalin; Szilagyi, Judit. And the article was included in Journal of Chromatography on August 16,1991.Safety of 2,6-Diamino-4-chloropyrimidine-1-oxide The following contents are mentioned in the article:

The retention behavior of minoxidil (I) and its intermediates (2,4-diamino-6-hydroxypyrimidine, 2,4-diamino-6-chloropyrimidine and 2,4-diamino-3-N-oxo-6-chloropyrimidine) was studied by using silica gel layers impregnated with tricaprylmethylammonium chloride (TCMA). The retention of the compounds increases with increasing concentration of TCMA adsorbed on the silica gel. The pH and the ionic strength of the eluents do not affect the retention at all. The retention of the solutes decreases with increasing methanol content of the eluent, because of the TCMA-desorbing effect of methanol. On the basis of these and earlier findings, it was concluded that no ion-pairing occurs during the separation A monolayer is formed on the silica surface at 0.1-0.2 M TCMA concentration in the impregnating solution, and hydrophobic interactions play an important role in the separation mechanism. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Safety of 2,6-Diamino-4-chloropyrimidine-1-oxide).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Safety of 2,6-Diamino-4-chloropyrimidine-1-oxide

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

Pyrimidine N-oxides. II. The synthesis of some amino- and iminopyrimidine N-oxides and related compounds was written by Cowden, William B.; Jacobsen, Noel W.. And the article was included in Australian Journal of Chemistry on September 30,1979.Computed Properties of C4H5ClN4O The following contents are mentioned in the article:

The course of peroxy acid oxidation of pyrimidinetriamines I (R = H, halogen, alkyl, NO2, etc.) and related compounds depends on the nature of R as well as on the nature of the amine groups in positions 4 and 6. Thus non-hydrolyzable R groups favor N-oxidation on the ring, whereas hydrolyzable R groups favor rearrangement to 6-amino-s-triazine-2,4-dione. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Computed Properties of C4H5ClN4O).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Computed Properties of C4H5ClN4O

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4