Category: 35139-67-4

Determination of minoxidil in bulk drug and pharmaceutical formulations by ion-pairing high-performance liquid chromatography was written by Asmus, P. A.; Landis, J. B.; Grant, M. E.; Havel, H. A.. And the article was included in Journal of Pharmaceutical Sciences on September 30,1984.Quality Control of 2,6-Diamino-4-chloropyrimidine-1-oxide The following contents are mentioned in the article:

Minoxidil (I) [38304-91-5] was determined in bulk, tablet and topical solutions by ion-pairing liquid chromatog. The chromatog. system consists of a microparticulate octadecylsilica column and a mobile phase composed of sodium dioctylsulfosuccinate in aqueous MeOH (pH3) and UV detection. The bulk drug and the topical solution samples are prepared by the dissolution of the drug in internal standard solution Sample preparation for the compressed tablet formulation involves dissolving the drug from an aliquot of pulverized sample and centrifuging to remove insoluble excipients. Quant. recovery of I from formulation excipients was demonstrated; assay precision was <10% relative standard deviation. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Quality Control of 2,6-Diamino-4-chloropyrimidine-1-oxide).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Quality Control of 2,6-Diamino-4-chloropyrimidine-1-oxide

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

Separation of minoxidil and its intermediates by overpressured layer chromatography using a stationary phase bonded with tricaprylmethylammonium chloride was written by Kovacs-Hadady, Katalin; Szilagyi, Judit. And the article was included in Journal of Chromatography on August 16,1991.Safety of 2,6-Diamino-4-chloropyrimidine-1-oxide The following contents are mentioned in the article:

The retention behavior of minoxidil (I) and its intermediates (2,4-diamino-6-hydroxypyrimidine, 2,4-diamino-6-chloropyrimidine and 2,4-diamino-3-N-oxo-6-chloropyrimidine) was studied by using silica gel layers impregnated with tricaprylmethylammonium chloride (TCMA). The retention of the compounds increases with increasing concentration of TCMA adsorbed on the silica gel. The pH and the ionic strength of the eluents do not affect the retention at all. The retention of the solutes decreases with increasing methanol content of the eluent, because of the TCMA-desorbing effect of methanol. On the basis of these and earlier findings, it was concluded that no ion-pairing occurs during the separation A monolayer is formed on the silica surface at 0.1-0.2 M TCMA concentration in the impregnating solution, and hydrophobic interactions play an important role in the separation mechanism. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Safety of 2,6-Diamino-4-chloropyrimidine-1-oxide).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Safety of 2,6-Diamino-4-chloropyrimidine-1-oxide

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

Pyrimidine N-oxides. II. The synthesis of some amino- and iminopyrimidine N-oxides and related compounds was written by Cowden, William B.; Jacobsen, Noel W.. And the article was included in Australian Journal of Chemistry on September 30,1979.Computed Properties of C4H5ClN4O The following contents are mentioned in the article:

The course of peroxy acid oxidation of pyrimidinetriamines I (R = H, halogen, alkyl, NO2, etc.) and related compounds depends on the nature of R as well as on the nature of the amine groups in positions 4 and 6. Thus non-hydrolyzable R groups favor N-oxidation on the ring, whereas hydrolyzable R groups favor rearrangement to 6-amino-s-triazine-2,4-dione. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Computed Properties of C4H5ClN4O).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Computed Properties of C4H5ClN4O

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

Determination of minoxidil in bulk drug and pharmaceutical formulations by ion-pairing high-performance liquid chromatography was written by Asmus, P. A.; Landis, J. B.; Grant, M. E.; Havel, H. A.. And the article was included in Journal of Pharmaceutical Sciences on September 30,1984.Quality Control of 2,6-Diamino-4-chloropyrimidine-1-oxide The following contents are mentioned in the article:

Minoxidil (I) [38304-91-5] was determined in bulk, tablet and topical solutions by ion-pairing liquid chromatog. The chromatog. system consists of a microparticulate octadecylsilica column and a mobile phase composed of sodium dioctylsulfosuccinate in aqueous MeOH (pH3) and UV detection. The bulk drug and the topical solution samples are prepared by the dissolution of the drug in internal standard solution Sample preparation for the compressed tablet formulation involves dissolving the drug from an aliquot of pulverized sample and centrifuging to remove insoluble excipients. Quant. recovery of I from formulation excipients was demonstrated; assay precision was <10% relative standard deviation. This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4Quality Control of 2,6-Diamino-4-chloropyrimidine-1-oxide).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Quality Control of 2,6-Diamino-4-chloropyrimidine-1-oxide

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4

Development and validation of stability indicating HPLC method for the estimation of Minoxidil and related substance in topical formulation was written by Gaidhane, Hemant K.; Bidada, Jagdish P.; Bhusari, Akshay S.; Navkhare, Manjusha S.; Diwanka, Ganesh P.; Tiwari, Ashish H.. And the article was included in Journal of Pharmacy Research on December 31,2011.SDS of cas: 35139-67-4 The following contents are mentioned in the article:

A sensitive HPLC method was developed and validated for the determination of minoxidil and related substances in a novel topical formulation. The highly polar mol. requires aqueous mobile phase for the elution and separation of Minoxidil and its impurities (Impurity A, B and E). The developed method is found to be specific, reproducible and stability indicating. The Phenomenex Synergi Polar RP 250 × 4.6 mm 4μ column was used and mobile phase contains 2.0mL of di-Et amine and 40mL of glacial acetic acid in 1000mL of milli Q water (Buffer) and 20% THF in methanol (mobile phase A & B resp.) to achieve good resolution and retention of the analyte and its related impurities. The detector linearity was established from concentrations ranging from 0.02-400 μg/mL for Minoxidil and from 0.02-1.0 μg/mL for related substances with a correlation co-efficient of 0.999. The relative response factor (RRF) values of impurity A, impurity B and impurity E determined from linearity plots were 0.24, 0.31 and 1.07 resp. The limit of detection (LOD) and limit of quantification (LOQ) found to be 0.02μg/mL and 0.1μg/mL resp. for Minoxidil and related substances. The mol. was stable in all the stress conditions such as acid, base, heat photolysis and unstable in oxidation as per the recommendations of ICH guidelines. The method was proved to be robust with respect to changes in flow rate, pH and column temperature This study involved multiple reactions and reactants, such as 2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4SDS of cas: 35139-67-4).

2,6-Diamino-4-chloropyrimidine-1-oxide (cas: 35139-67-4) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.SDS of cas: 35139-67-4

35139-67-4;2,6-Diamino-4-chloropyrimidine-1-oxide;The future of 35139-67-4;New trend of C4H5ClN4O;function of 35139-67-4