Category: 353272-15-8

Synthetic Route of 353272-15-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 353272-15-8, name is 6-Chloro-5-iodopyrimidin-4-amine. A new synthetic method of this compound is introduced below.

Compound (S)-3-(1-Aminoethyl)-8-chloro-2-cyclopropylisoquinolin-1(2H)-one (1.012 g, 3.852 mmol),6-chloro-5-iodopyrimidine-4-amine (1.04 g, 4.07 mmol)And triethylamine (993 mg, 7.606 mmol) in n-BuOH (10 mL)The mixture was heated to 125 C and stirring was continued for 48 hours.Then cool to room temperature,Concentrated under reduced pressure,The residue obtained was subjected to silica gel column chromatography (DCM/MeOH (v/v) = 100/1)The crude product obtained was purified by silica gel column chromatography (EtOAc/PE (v/v) = 1/2)The title compound was obtained as a pale yellow solid (430 mg. 23.1%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,353272-15-8, 6-Chloro-5-iodopyrimidin-4-amine, and friends who are interested can also refer to it.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Wang Liang; Wang Tingjin; Wu Weibin; (84 pag.)CN105130966; (2019); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 353272-15-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 353272-15-8, name is 6-Chloro-5-iodopyrimidin-4-amine, molecular formula is C4H3ClIN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a mixture of (5 -2-(l-amiiioethyl)-5-chloro-3-cyclopropylquinazolin-4(3H)- one (50 mg, 0.189 mmoi ), 6-chloro-5-iodopyrimidin-4-amine (48 mg, 0.189 mmoi) and DIPEA (49 mg, 0.379 mmoi) in n-BuOH (1 mL) was heated to reflux and stirred further for 16 hours, then cooled to rt, and concentrated in vacuo. The residue was purified by a silica gel column chromatography (DCM/MeOH (v/v) = 100/1 ) to give the title compound as a yellowish solid (49 mg, yield 53%). MS (ESI, pos. ion) m/z: 483.0 [M+H]+; FontWeight=”Bold” FontSize=”10″ H NMR (400 MHz, CDC13) delta (ppm): 7.98 (s, 1H), 7.55-7.53 (m, 2H), 7.43-7.41(dd, J = 3.6, 5.6 Hz, 1H), 6.41-6.39 (d, J= 7.8 Hz, 1H), 6.12-6.05 (m, 1H), 5.04 (s, 2H), 3.05-3.03 (m, 1H), 1.59- 1.57 (d, J= 6.2 Hz, 3H), 1.43-1.41 (m, 2H), 1.14-1.10 (m, 1H), 0.95-0.86 (m,lH).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 353272-15-8, 6-Chloro-5-iodopyrimidin-4-amine.

Reference:
Patent; CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.; XI, Ning; WANG, Liang; WANG, Tingjin; WU, Weibin; (123 pag.)WO2015/175579; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 353272-15-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.353272-15-8, name is 6-Chloro-5-iodopyrimidin-4-amine, molecular formula is C4H3ClIN3, molecular weight is 255.4442, as common compound, the synthetic route is as follows.

To a mixture of 6-chloro-5-iodopyrimidin-4-am.ine (500 mg, 0.196 mmol), Pd(PPh3)2Cl2 (69 mg, 0.10 mmol ) and Cul (19 mg, 0.10 mmol) under 2 atmosphere were added a solution of etiiynyltrimethylsilane (1 ,38 mL, 9.79 mmol) in DMF (1.5 mL) and a solution triethylamine (0.54 mL, 3.91 mmol) in DMF (1.5 mL), The resulted mixture was heated to 47 C and stirred further for 2 hours. The mixture was diluted with EtOAc (30 mL), and the resulted mixture was washed with water (20 mL x 2) and brine (20 mL). The separated organic phase was dried over anhydrous Na2S04 and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (v/v) ::: 10/1) to give the title compound as a brown solid (442 mg, yield 100%). MS (ESI, pos. ion) m/z: 226.0 [M+H]+; NMR (400 MHz, CDCb) delta (ppm): 8.31 (s, 1H), 5.62 (s, 2H), 0.31 (s, 9H).

Statistics shows that 353272-15-8 is playing an increasingly important role. we look forward to future research findings about 6-Chloro-5-iodopyrimidin-4-amine.

Reference:
Patent; CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.; XI, Ning; WANG, Liang; WANG, Tingjin; WU, Weibin; (123 pag.)WO2015/175579; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 353272-15-8, 6-Chloro-5-iodopyrimidin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 353272-15-8, blongs to pyrimidines compound. Recommanded Product: 353272-15-8

To a degassed solution of Example 1A (400 mg, 1.6 mmol) in N,N-dimethylformamide (6 mL) was added copper (I) iodide (120 mg, 0.63 mmol) and triethylamine (2 mL, 14.33 mmol). The mixture was degassed for 5 minutes and tert-butyl 4-ethynylpiperidine-1-carboxylate (1.67 g, 7.98 mmol) and bis(triphenylphosphine) palladium(II)chloride (220 mg, 0.31 mmol) were added. The mixture was stirred at room temperature for 3 hours and diluted with water and extracted with ethyl acetate. The ethyl acetate layers were washed with water and brine, dried over sodium sulfate, filtered, and concentrated. Purification by column chromatography (silica gel, 30% ethyl acetate in hexane) afforded the title compound. LCMS: 337.1 (M+1)+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,353272-15-8, 6-Chloro-5-iodopyrimidin-4-amine, and friends who are interested can also refer to it.

Reference:
Patent; Florjancic, Alan S.; Tong, Yunsong; Penning, Thomas D.; Souers, Andrew J.; Goswami, Rajeev; US2014/275004; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 353272-15-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 353272-15-8, name is 6-Chloro-5-iodopyrimidin-4-amine. A new synthetic method of this compound is introduced below.

Intermediate AA1: 3-(4-amino-6-chloropyrimidin-5-yl)prop-2-yn-1-ol A mixture of 6-chloro-5-iodopyrimidin-4-amine (prepared accordingly to the procedure reported in Tetrahedron Letters, 2010, 51, 27, 3597-3598, which is incorporated herein by reference in its entirety, 0.200 g, 0.78 mmol), 3-trimethylsiloxy-1-propyne (0.500 g, 3.94 mmol), CuI (0.052 g, 0.273 mmol) and diethylamine (0.95 mL, 8.57 mmol) in DMF (3.3 mL) was degassed and then Pd(PPh3)2Cl2 (0.097 g, 0.14 mmol) was added. The reaction was stirred at room temperature for 2 h, then diluted with EtOAc and filtered through a Celite pad. The filtrate was washed with water and brine, then dried over sodium sulfate, filtered and concentrated. The crude was purified by flash chromatography on Biotage silica-NH SNAP cartridge (cyclohexane:EtOAc=100:0 to 0:100) to afford title compound as a yellow solid (0.078 g, 0.42 mmol, 54% yield). MS/ESI+ 184.0 [MH]+, Rt=0.46 min (Method A).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,353272-15-8, 6-Chloro-5-iodopyrimidin-4-amine, and friends who are interested can also refer to it.

Reference:
Patent; CHIESI FARMACEUTICI S.P.A.; BIAGETTI, Matteo; ACCETTA, Alessandro; CAPELLI, Anna Maria; GUALA, Matilde; RETINI, Michele; US2015/361100; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 353272-15-8, 6-Chloro-5-iodopyrimidin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 6-Chloro-5-iodopyrimidin-4-amine, blongs to pyrimidines compound. Quality Control of 6-Chloro-5-iodopyrimidin-4-amine

Compound (S)-3-(1-Aminoethyl)-2-cyclopropyl-8-fluoroisoquinolin-1(2H)-one (425 mg, 1.726 mmol),6-chloro-5-iodopyrimidine-4-amine (463.8 mg, 1.816 mmol) andA mixture of DIPEA (445.5 mg, 3.447 mmol) in n-butanol (2.5 mL) was heated to 130 C and stirring was continued for 30 hours.After cooling to room temperature and concentrating under reduced pressure, EtOAc m.The crude product was purified by silica gel column chromatography (EtOAc/EtOAc)The title compound was obtained as a pale yellow solid (250 mg, 31%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,353272-15-8, 6-Chloro-5-iodopyrimidin-4-amine, and friends who are interested can also refer to it.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Wang Liang; Wang Tingjin; Wu Weibin; (84 pag.)CN105130966; (2019); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia