Category: 35621-01-3

Recommanded Product: Piperidin-4-amine dihydrochloride. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Piperidin-4-amine dihydrochloride, is researched, Molecular C5H14Cl2N2, CAS is 35621-01-3, about The synthesis of a series of 7-amino-1-cyclopropyl-8-fluoro-1,4-dihydro-4-oxo-1,6-naphthyridine-3-carboxylic acids as potential antibacterial agents. Author is Sanchez, Joseph P.; Gogliotti, Rocco D..

A series of title compounds I [R = 3-aminopyrrolidin-1-yl, 3-(ethylaminomethyl)pyrrolidin-1-yl, 4-aminopiperidin-1-yl, piperazin-1-yl] was prepared and evaluated for antibacterial activity (no data). I were prepared by the displacement of the chloro substituent from I (R = Cl) with the requisite nitrogen nucleophile. The naphthyridine acid was synthesized in ten steps from pyridinecarboxylate II (R1 = OH, R2 = NO2). The key step in the sequence was a Schiemann reaction of II (R1 = Cl, R2 = N2+ PF6-) to give II (R1 = Cl, R2 = F).

From this literature《The synthesis of a series of 7-amino-1-cyclopropyl-8-fluoro-1,4-dihydro-4-oxo-1,6-naphthyridine-3-carboxylic acids as potential antibacterial agents》,we know some information about this compound(35621-01-3)Recommanded Product: Piperidin-4-amine dihydrochloride, but this is not all information, there are many literatures related to this compound(35621-01-3).

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Solvent-free N-Boc deprotection by ex situ generation of hydrogen chloride gas》. Authors are Verschueren, Rik H.; Gilles, Philippe; Van Mileghem, Seger; De Borggraeve, Wim M..The article about the compound:Piperidin-4-amine dihydrochloridecas:35621-01-3,SMILESS:NC1CCNCC1.[H]Cl.[H]Cl).Related Products of 35621-01-3. Through the article, more information about this compound (cas:35621-01-3) is conveyed.

An efficient, scalable and sustainable method for the quant. deprotection of the tert-Bu carbamate (N-Boc) protecting group is described, using down to near-stoichiometric amounts of hydrogen chloride gas in solvent-free conditions. The ex situ generation of hydrogen chloride gas from sodium chloride and sulfuric acid in a two-chamber reactor, introducing a straightforward method for controlled and stoichiometric release of HCl gas were demonstrated. The solvent-free conditions allow deprotection of a wide variety of N-Boc derivatives e.g., N-Boc benzylamine to obtain the hydrochloride salts in e.g., benzylamine hydrochloride quant. yields. The procedure obviates the need for any work-up or purification steps providing an uncomplicated green alternative to standard methods. Due to the solvent-free, anhydrous conditions, this method shows high tolerance towards acid sensitive functional groups and furnishes expanded functional group orthogonality.

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Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia