Category: 36075-35-1

Paterson, Thomas published the artcileSpecific enzyme inhibitors in vitamin biosynthesis. I. Synthesis of 8-substituted pyrido[2,3-d]pyrimidines, SDS of cas: 36075-35-1, the main research area is pyridopyrimidine uracil crotonaldehyde; riboflavin analog.

Condensation of 6-(substituted amino)uracils with α,β-unsaturated carbonyl compounds gave 8-substituted pyrido[2,3-d]pyrimidones; e.g., 6-[(2-hydroxyethyl)-amino]uracil (I) reacted with MeCH:CHCHO in 20% HCl at room temperature to give 72% 5,6,7,8-tetrahydro-7-methyl-5,8-(1-oxapropano)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione, which on heating in Ph2O gave 81% 8-(2-hydroxyethyl)-7-methylpyrido[2,3-d]pyrimidine-2,4(3H,8H)-dione (II; R = H, R1 = Me). Substituted pyrido[2,3-d]pyrimidones were also prepared by condensation of 6-(substituted amino)uracils with β-dicarbonyl derivatives; e.g. I with the Na salt of AcCHMeCHO in 85% phosphoric acid gave 47% II (R = Me, R1 = H). PMR studies of II showed that D exchange of protons on C-Me groups at positions 5 and 7 occurred in alk. solution, but protons on a 6-Me group did not exchange; a highly delocalized anionic species was implicated.

Journal of the Chemical Society, Perkin Transactions 17: Organic and Bio-Organic Chemistry published new progress about pyridopyrimidine uracil crotonaldehyde; riboflavin analog. 36075-35-1 belongs to class pyrimidines, name is 7-Methylpyrido[2,3-d]pyrimidine-2,4-diol, and the molecular formula is C8H7N3O2, SDS of cas: 36075-35-1.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Hughes, David D. published the artcileOne or two-step Bohlmann-Rahtz heteroannulation of 6-aminouracil derivatives for the synthesis of pyrido[2,3-d]pyrimidines, Formula: C8H7N3O2, the main research area is aminouracil alkynone Bohlmann Rahtz heteroannulation; pyrido pyrimidine preparation.

The Michael addition-cyclodehydration of a 6-aminouracil and alkynone proceeds to give 5-deazapterin derivatives with total control of regiochem. This simple and facile cyclocondensation process is catalyzed by zinc(II) bromide or ytterbium(III) trifluoromethanesulfonate at 110°, providing the heteroannulated products in up to 94% yield.

Synlett published new progress about Bohlmann-Rahtz reaction. 36075-35-1 belongs to class pyrimidines, name is 7-Methylpyrido[2,3-d]pyrimidine-2,4-diol, and the molecular formula is C8H7N3O2, Formula: C8H7N3O2.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Wood, Hamish C. S. published the artcileSpecific enzyme inhibitors in vitamin biosynthesis. II. Revised structures for 8-substituted pyrido[2,3d]pyrimidines, Formula: C8H7N3O2, the main research area is structure pyridopyrimidine; inhibition riboflavin synthetase pyridopyrimidine.

Condensation of 6-D-ribitylaminouracil (I) with MeCH:CMeCHO and MeCOCHMeCHO gave the pyridopyrimidines II and III resp. and not, as previously stated by T. Paterson and H. C. S. Wood, 1972, III and II resp. The structures were determined by nuclear Overhauser and photochem. degradation studies. The structures originally proposed were shown to be incorrect byenzyme inhibition studies.

Journal of the Chemical Society, Perkin Transactions 16: Organic and Bio-Organic Chemistry published new progress about Doebner-Miller cyclization. 36075-35-1 belongs to class pyrimidines, name is 7-Methylpyrido[2,3-d]pyrimidine-2,4-diol, and the molecular formula is C8H7N3O2, Formula: C8H7N3O2.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Li, Chun published the artcileIonic liquid promoted synthesis of heterocycle-fused pyrimidine-2,4(1H,3H)-diones utilising CO2, Computed Properties of 36075-35-1, the main research area is heterocycle pyrimidine dione preparation green chem; carbon dioxide cyclization ionic liquid catalyst.

An efficient ionic liquid system was developed for the preparation of various heterocycle-fused pyrimidine-2,4(1H,3H)-diones in moderate to excellent yields (52-95%). It was found that 1,5-diazabicyclo[4.3.0]non-5-ene trifluoroethanol [HDBN+][TFE-], a simple and easily prepared ionic liquid, could act as both the solvent and reaction promoter, and that the reactions could be efficiently carried out at atm. pressures of CO2.

Tetrahedron Letters published new progress about Fused heterocyclic compounds Role: SPN (Synthetic Preparation), PREP (Preparation). 36075-35-1 belongs to class pyrimidines, name is 7-Methylpyrido[2,3-d]pyrimidine-2,4-diol, and the molecular formula is C8H7N3O2, Computed Properties of 36075-35-1.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia