Category: 36082-45-8

Adding a certain compound to certain chemical reactions, such as: 36082-45-8, 2-Amino-5-bromo-4-methoxypyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C5H6BrN3O, blongs to pyrimidines compound. Formula: C5H6BrN3O

Intermediate U: 4-Methoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrimidin-2-ylamine A mixture of 2-amino-5-bromo-4-methoxypyrimidine [36082-45-8] (11.1 mmol), bis(pinacolato)diboron (12.2 mmol), PdCl2(dppf).CH2Cl2 adduct (0.555 mmol) and potassium acetate (33.3 mmol) in dioxane (60 mL) was stirred at 115 C. under argon for 20 h, allowed to cool to rt, diluted with toluene (60 mL), sonicated, and filtered through celite. The celite cake was rinsed with hot toluene (2*). The filtrate was concentrated to afford the title compound (30% purity) which was used without purification. ESI-MS: tR=0.22 min; [M+H]+ 170 (boronic acid) (LC-MS 1).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,36082-45-8, 2-Amino-5-bromo-4-methoxypyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; NOVARTIS AG; Cotesta, Simona; Furet, Pascal; Guagnano, Vito; Holzer, Philipp; Kallen, Joerg; Mah, Robert; Masuya, Keiichi; Schlapbach, Achim; Stutz, Stefan; Vaupel, Andrea; US2013/317024; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 36082-45-8, Adding some certain compound to certain chemical reactions, such as: 36082-45-8, name is 2-Amino-5-bromo-4-methoxypyrimidine,molecular formula is C5H6BrN3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 36082-45-8.

Method 15; Synthesis of 4-methoxy-5-(4,4,5,5-tetramethyl- (1,3 ,2-dioxaborolan-2-yl))pyrimidine-2-ylamine; [0256] To a dry 200-mL flask was added 5-bromo-4-methoxypyrimidine-2- ylamine (2.88 g, 14.1 mmol), potassium acetate (4.16 g, 42.4 mmol), 4,4,5,5-tetramethyl- 2-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-l,3,2-dioxaborolane (3.76 g, 14.8 mmol) and dioxane (75 mL). Argon was bubbled through the solution for 15 minutes, at which time 1 , l’-bis(diphenylphosphino)ferrocene palladium(II) chloride dichloromethane adduct (0.58 g, 0.71 mmol). The reaction was refluxed in a 115 0C oil bath for 21 hours under argon. After cooling to room temperature, the dioxane was removed in vacuo. EtOAc (500 mL) was added and the resulting slurry was sonicated and filtered. Additional EtOAc (500 mL) was used to wash the solid. The combined organics were concentrated and the crude material was purified by silica gel chromatography (EtOAc as eluent) yielding 2.4 g of an off white solid. By 1H NMR the material was a 1 :1 mixture of boronate ester and 4-methoxypyrimidine-2-ylamine. The material was used as is in subsequent Suzuki reactions. LCMS (m/z): 170 (MH+ of boronic acid, deriving from in situ product hydrolysis on LC); 1H NMR (CDCl3): delta 8.42 (s, IH), 5.22 (bs, 2H), 3.90 (s, 3H), 1.34 (s, 12H).

According to the analysis of related databases, 36082-45-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVARTIS VACCINES AND DIAGNOSTICS, INC.; WO2008/98058; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia