Category: 36082-50-5

Reference of 36082-50-5 ,Some common heterocyclic compound, 36082-50-5, molecular formula is C4HBrCl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Preparation of 5-Bromo-2-chloro-4-methylsulfanyl-pyrimidine 2 g of MeSNa (28.5 mmol; 1 eq.) and 6.5 g of 5-bromo-2,4-dichloropyrimidine (28.5 mmol, 1 eq.) were stirred in 50 mL dry acetonitrile at rt for 24 h. Then the mixture was poured into water, extracted with DCM, dried (Na2SO4) and evaporated to dryness. The product was recrystallized from hexane to yield 4 g of Intermediate 10 (70 % yield). 1H-NMR (400 MHz, CDCl3): 8.31 (s, 1 H); 2.59 (s, 3 H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 36082-50-5, 5-Bromo-2,4-dichloropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Bayer Schering Pharma Aktiengesellschaft; EP1878726; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 36082-50-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.36082-50-5, name is 5-Bromo-2,4-dichloropyrimidine, molecular formula is C4HBrCl2N2, molecular weight is 227.8741, as common compound, the synthetic route is as follows.

12a Production of 4-(5-Bromo-2-chloro-pyrimidin-4-ylamino)-butan-1-ol A solution of 2.28 g (10.0 mmol) of 5-bromo-2,4-dichloro-pyrimidine and 1.7 ml (12.0 mmol) of triethylamine in 10 ml of acetonitrile is mixed at 0 C. with 1.1 ml (12.0 mmol) of 4-amino-butanol. The reaction mixture is slowly heated to room temperature while being stirred by removal of the ice bath. After 16 hours, the precipitate that is formed is filtered off. The filtrate is completely concentrated by evaporation and digested with diisopropyl ether. 2.74 g (9.8 mmol, corresponding to 98% of theory) of the product is obtained. 1H-NMR (DMSO): 8.19 (s, 1H), 7.72 (t, 1H), 4.45 (br, 1H), 3.38 (m, 4H), 1.56 (m, 2H), 1.45 (m, 2H). MS: 279 (EI).

The chemical industry reduces the impact on the environment during synthesis 36082-50-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Schering AG; US2004/209895; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 36082-50-5 ,Some common heterocyclic compound, 36082-50-5, molecular formula is C4HBrCl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

5-Bromo-2,4-dichloropyrimidine B1-a (2.28 g, 10 mmol) and 30 mL of tetrahydrofuran were sequentially added to a dry 100 mL one-necked flask, and a 2N aqueous sodium hydroxide solution (10 mL, 20 mmol) was stirred under ice-cooling. The reaction temperature was raised to room temperature and the reaction was stirred at room temperature for 6 hours. After completion of the reaction, the reaction solution was cooled to 0 C and the pH of the reaction solution was adjusted to 3-4 using a 6N hydrochloric acid solution. The mixture was extracted with chloroform (50 mL×3) and EtOAc (1.8 g, 86% yield).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 36082-50-5, 5-Bromo-2,4-dichloropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shanghai Qingyu Pharmaceutical Technology Co., Ltd.; Zou Bin; Ma Shichao; Fu Xianlei; Dong Hongping; (130 pag.)CN109942556; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 36082-50-5, 5-Bromo-2,4-dichloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 5-Bromo-2,4-dichloropyrimidine, blongs to pyrimidines compound. Safety of 5-Bromo-2,4-dichloropyrimidine

f) Production of methyl-N-(5-bromo-2-chloropyrimidin-4-yl)-D-alaninate 22.8 g (100 mmol) of 5-bromo-2,4-dichloropyrimidine and 14.0 g (100 mmol) of D-alanic acid methyl ester hydrochloride are dissolved in 300 ml of THF and 75 ml of DMF. The ice-cooled batch is mixed with 33.5 ml (240 mmol) of triethylamine and then slowly heated to room temperature. After 48 hours, the solvent is drawn off in a rotary evaporator, and the remaining residue is purified by chromatography (hexane/ethyl acetate: 4:1 – 2:1). 25.5 g (86.1 – mmol, corresponding to 86% of theory) of the product is obtained. 1H-NMR (CDCl3): 8.2 (s, 1 H), 6.1 (d, 1 H), 4.8 (m, 1 H), 3.8 (s, 3H), 1.6 (d, 3H).

The synthetic route of 36082-50-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Schering Aktiengesellschaft; EP1705177; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 36082-50-5, Adding some certain compound to certain chemical reactions, such as: 36082-50-5, name is 5-Bromo-2,4-dichloropyrimidine,molecular formula is C4HBrCl2N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 36082-50-5.

General procedure: Heteroaryl chloride (1.0 eq), the corresponding amino alcohol (1.1 eq) and triethylamine (1.5 eq), were dissolved in n-BuOH (1 mL). The resulting reaction mixture was degassed with argon and irradiated in a commercial microwave apparatus at 125 C (30 W) for 1 h. Upon completion the solvent was removed under reduced pressure. The residue was purified by flash column chromatography (methanol : dichloromethane; 1:9) to afford the title compound.

According to the analysis of related databases, 36082-50-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Gill, Daniel M.; Iveson, Matthew; Collins, Ian; Jones, Alan M.; Tetrahedron Letters; vol. 59; 3; (2018); p. 238 – 242;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 36082-50-5, 5-Bromo-2,4-dichloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyrimidines, blongs to pyrimidines compound. category: pyrimidines

To a stirred solution of 5-bromo-2,4-dichloropyrimidine (500 mg, 2.19 mmol) in MeOH (5 mL) was added a 30% solution of sodium methoxide (0.40 mL, 2.26 mmol). The reaction mixture was stirred at RT for 2 h then concentrated. The residue was dissolved in water (5 mL) and extracted with EA (3 x 5 mL). The combined organic layer was washed with brine, dried over MgS04 and concentrated to afford 432 mg (88%) of 5-bromo-2-chloro-4-methoxypyrimidine as white solid. LCMS- ESI (m/z) calculated for C5H4BrClN20: 223.4; found 224.2 [M+H]+, tR = 7.66 min. (Method 2).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,36082-50-5, 5-Bromo-2,4-dichloropyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; RECEPTOS, INC.; BOEHM, Marcus, F.; MARTINBOROUGH, Esther; MOORJANI, Manisha; TAMIYA, Junko; HUANG, Liming; YEAGER, Adam, R.; BRAHMACHARY, Enugurthi; FOWLER, Thomas; NOVAK, Andrew; MEGHANI, Premji; KNAGGS, Michael; WO2013/90454; (2013); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 36082-50-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 36082-50-5, name is 5-Bromo-2,4-dichloropyrimidine, molecular formula is C4HBrCl2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 5-bromo-2, 4-dichloro-pyrimidine (1. 4 G) in acetonitrile (10 mL) at 0C was added triethylamine (0. 94 ML) and 3-AMINOPROPYLCARBAMIC acid-1,1- dimethylethyl ester (1.0 G). After removing the cooling bath the reaction mixture was stirred overnight at room temperature. The reaction mixture was concentrated and to the residue water (20 ML) was added. The precipitate was collected, washed with water and ether to afford the title compound (1.8 g). ‘H NMR (400 MHz, DMSO-d6) : O/PPM = 1.34 (s, 9H), 1.62 (m, 2H), 2.93 (m, 2H), 3.36 (m, 2H), 6.78 (t, 1H), 7.64 (t, 1H), 8.22 (s, 1H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 36082-50-5, 5-Bromo-2,4-dichloropyrimidine.

Reference:
Patent; SCHERING AKTIENGESELLSCHAFT; WO2004/48343; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 36082-50-5 ,Some common heterocyclic compound, 36082-50-5, molecular formula is C4HBrCl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

ntermedate Iyi2coro56dilidrogm .d [4J,jjflpje7carbox(jata(amo-2-chloro-rimidin-4-amineTo a solution of 5-bromo-2,4dichloro-pyrimidine (150 g; 658 mmol) in THE (445 mL) was added ammoniumhydroxide (25% in water, 250 mL) and the resufting reaction mixture was stirred at room temperature for 90 mm. The mixture was subsequently evaporated to a small volume and partitioned between ethyl acetate and water. The organic phase wasseparated and washed with water and brine, dried over sodium sulfate, filtered andconcentrated to give 137.3 g (quant. yield) of 5-bromo2-chloro-pyrimidin4-amine.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 36082-50-5, 5-Bromo-2,4-dichloropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NETHERLANDS TRANSLATIONAL RESEARCH CENTER B.V.; DE MAN, Adrianus Petrus Antonius; BUIJSMAN, Rogier Christian; STERRENBURG, Jan Gerard; UITDEHAAG, Joost Cornelis Marinus; DE WIT, Joeri Johannes Petrus; ZAMAN, Guido Jenny Rudolf; WO2015/155042; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 36082-50-5 ,Some common heterocyclic compound, 36082-50-5, molecular formula is C4HBrCl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a stirred solution of 5-bromo-2,4-dichloropyrimidine (A, 5 g, 22.2 mmol) in MeOH (100 mL) was added NaOMe (1.6 g, 28.88 mmol) at 0 C and the reaction was stirred at r.t for 6 h. The reaction mixture was evaporated; the crude was taken in water and extracted with ethyl acetate (2 x 150 mL). The combined organic layer was washed with brine solution, dried over sodium sulfate and evaporated. The crude was purified on combiflash MPLC using 2% ethyl acetate in hexanes as eluent to afford 5-bromo-2-chloro-4-methoxypyrimidine as white crystalline solid (Al, yield: 4 g, 82%). LCMS (ES) m/z = 222.9, 224.9 [M] +, [M+2H]+; lH NMR (400 MHz, DMSO- d6) delta ppm: 4.01 (s, 3 H), 8.69 (s, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 36082-50-5, 5-Bromo-2,4-dichloropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; JUBILANT BIOSYS LIMITED; VENKATESHAPPA, Chandregowda; DURAISWAMY, Athisayamani Jeyaraj; PUTTA, Rama Kishore V P; RAJAGOPAL, Sridharan; (179 pag.)WO2019/87214; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 36082-50-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 36082-50-5 as follows.

Step 1 1 mol/L Sodium hydroxide (150 mL) was added to mixture of 5-bromo-2,4-dichloropyrimidine (25 g, 110 mmol) and THF (50 mL), and stirred at room temperature for 3.5 hours, the reaction mixture was neutralized with 2 mol/L hydrochloride, and extracted with chloroform (150 mL). The organic phase was washed by saturated saline (100 mL), and dried over anhydrous magnesium sulfate. After concentrated in vacuo, the residue was added to chloroform and hexane, and the resulting powder was filtered to give 5-bromo-2-chloropyrimidin-4(3H)-one (6.15 g, yield: 27%) as white powder. 1H-NMR (delta ppm TMS/DMSO-d6): 8.37 (1H, s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,36082-50-5, its application will become more common.

Reference:
Patent; Shionogi & Co., Ltd.; KAI, Hiroyuki; TANAKA, Satoru; HIRAMATSU, Yoshiharu; NOZU, Azusa; NAKAMURA, Ken’ichioh; (260 pag.)US2016/24072; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia