Category: 36314-98-4

Reference of 36314-98-4 ,Some common heterocyclic compound, 36314-98-4, molecular formula is C5H4N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

40-48wt.% aqueous ammonium sulfide (8.27ml, 48.5mmol) was added to a mixture of 57 (5.3g, 44.1mmol), triethylamine (6.14ml, 44.1mmol), and pyridine (28.8ml, 353mmol) and the resulting suspension was stirred at 52C for 2h. The mixture was concentrated under reduced pressure and H2O was added to the residue. The mixture was chilled to 0C and the resulting precipitate was removed by filtration to deliver 2-aminopyrimidine-4-carbothioamide (5.5g, 35.7mmol, 80% yield) as a yellow solid. 1H NMR (400MHz, DMSO-d6) delta ppm 10.23 (br. s, 1H), 9.58 (br. s, 1H), 8.42 (d, J=4.9Hz, 1H), 7.35 (d, J=4.9Hz, 1H), 6.80 (br. s, 2H). MS (ESI, pos. ion) m/z: 155.1 (M+1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 36314-98-4, 2-Amino-4-cyanopyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Reichelt, Andreas; Bailis, Julie M.; Bartberger, Michael D.; Yao, Guomin; Shu, Hong; Kaller, Matthew R.; Allen, John G.; Weidner, Margaret F.; Keegan, Kathleen S.; Dao, Jennifer H.; European Journal of Medicinal Chemistry; vol. 80; (2014); p. 364 – 382;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 36314-98-4, name is 2-Amino-4-cyanopyrimidine. A new synthetic method of this compound is introduced below., Recommanded Product: 2-Amino-4-cyanopyrimidine

Step 2: Synthesis of 1-37.2To a solution of 1-37.1 (100 mg, 0.83 mmol) in CH3CN (10 mL) is added NBS (222 mg, 1.2 mmol) at room temperature. The solution is stirred at the same temperature for 12 hours. The solution is concentrated and the residue is purified by silica gel flash column chromatography with 10% MeOH in CH2C12 as the eluent to afford 1-37.2 (100 mg); m/z: 200 [M++l]

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 36314-98-4, 2-Amino-4-cyanopyrimidine.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BARTOLOZZI, Alessandra; BOSANAC, Todd; CHEN, Zhidong; DE LOMBAERT, Stephane; HUBER, John, D.; LIU, Weimin; LO, Ho Yin; LOKE, Pui Leng; RIETHER, Doris; TYE, Heather; WU, Lifen; ZINDELL, Renee, M.; WO2012/40137; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.36314-98-4, name is 2-Amino-4-cyanopyrimidine, molecular formula is C5H4N4, molecular weight is 120.11, as common compound, the synthetic route is as follows.SDS of cas: 36314-98-4

Intermediate 1-11-4To a solution of 2-aminopyrimidine-4-carbonitrile (1 g, 8.3 mmol) in 7M NH3 in MeOH (25.5 mL) was added Raney-Nickel (50% wet, 1.955 g, 33 mmol) and stirred at RT under an H2 atmosphere (32.5 bar) for 22h. The reaction was filtered and concentrated to give the intermediate 1-11-4 (954 mg, 92%) which was used without further purification.1H-NMR (400 MHz ,DMSO-d6), Shift [ppm]= 3.55 (2H), 6.34-6.54 (2H), 6.63 (1H), 8.09- 8.21 (1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,36314-98-4, 2-Amino-4-cyanopyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; GRAHAM, Keith; KLAR, Ulrich; BRIEM, Hans; HITCHCOCK, Marion; BAeRFACKER, Lars; EIS, Knut; SCHULZE, Volker; SIEMEISTER, Gerhard; BONE, Wilhelm; SCHROeDER, Jens; HOLTON, Simon; LIENAU, Philip; TEMPEL, Rene; SONNENSCHEIN, Helmut; BALINT, Jozsef; GRAUBAUM, Heinz; (577 pag.)WO2015/193339; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia