Category: 36315-01-2

Electric Literature of 36315-01-2 ,Some common heterocyclic compound, 36315-01-2, molecular formula is C6H9N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure for thiocyanation of aminopyrimidine derivatives: Ammonium thiocyanate (3 mmol) and iodine (1.0 mmol) are added at room temperature to a stirred solution of the corresponding aminopyrimidine derivative (1.0 mmol) in methanol (10 mL). After completion of the reaction (TLC control), a sodium thiosulfate solution [20% (w/v)] is added to destroy the remaining iodine. The solid formed is filtered off, washed with water, and recrystallized from a methanol/water solution. For more details see Table 1 and Supplementary data.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 36315-01-2, 2-Amino-4,6-dimethoxypyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Rodriguez, Ricaurte; Camargo, Patricia; Sierra, Cesar A.; Soto, Carlos Y.; Cobo, Justo; Nogueras, Manuel; Tetrahedron Letters; vol. 52; 21; (2011); p. 2652 – 2654;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 36315-01-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 36315-01-2, name is 2-Amino-4,6-dimethoxypyrimidine. A new synthetic method of this compound is introduced below.

STR1346 A mixture of 15.5 g (0.1 mole) of 2-amino-4,6-dimethoxy-pyrimidine, 13.1 g (0.1 mole) of ethoxycarbonyl isothiocyanate and 200 ml of acetonitrile is stirred for 2 hours at 60 C. Thereafter, the mixture is cooled to 10 C., and the crystalline product obtained is isolated by filtration with suction. 22.5 g (79% of theory) of 1-(ethoxycarbonyl)-3-(4,6-dimethoxy-pyrimidin-2-yl)-thiourea of melting point 194 C. (decomposition) are obtained.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,36315-01-2, 2-Amino-4,6-dimethoxypyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Bayer Aktiengesellschaft; US4840661; (1989); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.36315-01-2, name is 2-Amino-4,6-dimethoxypyrimidine, molecular formula is C6H9N3O2, molecular weight is 155.16, as common compound, the synthetic route is as follows.Computed Properties of C6H9N3O2

To 50 ml pear-shaped flask add 155 mg (1 mmol) of 2 – amino – 4, 6 – dimethoxy pyrimidine solid and 8 ml of dried DMF, stirring to dissolve adding 2 g water-free K2CO3, Stirring under the room temperature condition 0.5 h, then to slow added in the reaction system of 270 mg (1 mmol) of 5 – bromo valeric acid O-methyl ester, stir at room temperature overnight TLC monitoring to the reaction is complete. After the reaction is finished adding 40 ml of water, then 2 × 50 ml ethyl acetate, the combined organic phase sequentially for 2 × 50 ml of 1 N HCl solution, 2 × 50 ml of saturated sodium chloride solution. The organic phase after drying over anhydrous sodium sulfate the solvent is removed by reduced pressure distillation after purification on silica gel, ethyl acetate/petroleum ether (v/v, 4/1) elution, to obtain light yellow oily liquid, yield 72%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,36315-01-2, 2-Amino-4,6-dimethoxypyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Northwest A&F University; Ji Zhiqin; Wei Shaopeng; (12 pag.)CN107857735; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 36315-01-2, 2-Amino-4,6-dimethoxypyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2-Amino-4,6-dimethoxypyrimidine, blongs to pyrimidines compound. Safety of 2-Amino-4,6-dimethoxypyrimidine

One pot procedure for the synthesis of 2-amino-5,7-dimethoxy [1,2, 4] triazolopyrimidine (ADTP) from 2-amino-4,6-dimethoxypyrimidine (ADP) 11. 9 g (0.075 mol) ADP was dissolved in 68 g ethyl acetate. 11 g (0.0825 mol) ethoxycarbonyl isothiocyanate was added within 20 min. at 78C (no exotherm). The mixture was stirred over 5 h at reflux (78-79C). 49.2 g (0.075 mol) hydroxylammonium sulfate (25 % solution in water) were added and the mixture heated to 71C (reflux aceotrope). 50 g (0.1 mol) diluted caustic soda (2 mot/1) was added within 1 h to establish the pH from 1.3 to 6.5 and hold at 6.5-7. 0 (offgas C02 and H2S, slightly exotherm). The mixture was stirred over 6 h under reflux (71C) for reaction completion. The mixture was cooled down over night to 20C. The product (ADTP) was filtrated and washed 3 times with each 25 g water to remove the salt (Na content after first wash 0.42 %, after second 0.20 %, after third 0.025 %). Finally the solid ADTP was dried. Yield : 91.1 % in respect to ADP, purity 95.3 % (quantitative HPLC assay).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,36315-01-2, 2-Amino-4,6-dimethoxypyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; BASF AKTIENGESELLSCHAFT; WO2005/63753; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 36315-01-2, name is 2-Amino-4,6-dimethoxypyrimidine, molecular formula is C6H9N3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 2-Amino-4,6-dimethoxypyrimidine

In a 3000 liter glass-lined reactor, 2000 kg of metered methylene chloride, 580 kg of [3-(N,N-dimethylaminocarbonyl-2-pyridyl)sulfonylamino]carboxylic acid phenyl ester and 215 kg of pyrimidinamine were added, heated to 40 C (heating rate of 5 C / h), and stirred for 5 hours. Pyrimidineamine was detected by thin layer chromatography, the end point was an unreacted pyrimidine amine with a mass concentration of less than 2%. The developing solvent for thin layer chromatography was a mixed solvent of chloroform and methanol (volume ratio of 2:1). Until the end of the reaction, a solution of 150 kg of sodium carbonate and 400 kg of water were added, stirred, layers were separated, and the aqueous layer were neutralized with hydrochloric acid (30%) to precipitate nicosulfuron crystallization hydrate. The filtrate was cooled to 15 C, filtered (reduced rate was 10 C / h), and the filter cake was dried at 50 C for 4 hours and then sampled and measured. When the material was measured to constant weight and dried, and 543 kg of the finished nicosulfuron crystallization hydrate was obtained, the yield was 95.47%, and the content of the external standard method was 98.11%.

With the rapid development of chemical substances, we look forward to future research findings about 36315-01-2.

Reference:
Patent; Zibo Xin Nongji Crop Science Co., Ltd.; Zheng Youkui; Cui Yuanxing; Shao Changlu; Huang Hua; (11 pag.)CN110330480; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 36315-01-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 36315-01-2, name is 2-Amino-4,6-dimethoxypyrimidine. A new synthetic method of this compound is introduced below.

In a 1 OOO mL reaction flask, 100 g of 2-sulfonyl chloride-N, N-dimethylnicotinamide (0.40 mol) 40 g of sodium cyanate (0.62 mol), 101 g of triethylamine (1.00 mol) and 125 g of acetonitrile were charged and the mixture was stirred at 25 ± 5 C for isocyanating. After 5 h, 75 g of 2-amino-4,6-dimethoxypyrimidine (0.48 mol) was added to the reaction flask and stirred for 1 h at ambient temperature (0 to 40 C). After the completion of the condensation reaction, 500 g of deionized water (about 1.5 h) was added dropwise to the reaction bottle. After dropping, the pH was adjusted to 1.0 with hydrochloric acid, After drying, 157.8 g of nicosulfuron were obtained in a yield of 92.1% and a purity of 95.7%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,36315-01-2, 2-Amino-4,6-dimethoxypyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Jiangsu agricultural hormone Engineering Technology Research Center Co., Ltd.; Jiangsu Hormone Research Institute Co., Ltd; Sun, Yong Hui; kong, Fan Lei; Shi, yueping; Gao, Jian Hong; Zhang, Yuan yuan; Cao, Wei; (5 pag.)CN103524493; (2016); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 36315-01-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 36315-01-2, name is 2-Amino-4,6-dimethoxypyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: For the synthesis of 2, the solution of sulfurisocyanatidic chloride (7.2mmol) in 20mL toluene was added to the solution of 1 (6.0mmol) in 20mL toluene dropwise at room temperature. The reactant was heated to 140C and then the reaction proceeded for 18h under reflux. Subsequently, the mixture was cooled down to room temperature and remaining sulfurisocyanatidic chloride was removed under reduced pressure, together with the solvent. Without further purification, the resulting yellow oil 2 was dissolved in 10mL anhydrous acetonitrile and after that it was added slowly to 5mmol of 3, which was also dissolved in 10mL anhydrous acetonitrile beforehead in ice bath. After stirring for 24hat room temperature, acetonitrile was removed under reduced pressure and saturated sodium bicarbonate was added to product 4. Product 5 precipitated easily and it was further purified by recrystallization from petroleum ether/acetone in 1:1 ratio in high yields. 15% hydrochloric acid was added to aqueous solution of 5 under stirring and corresponding acidified product 4 precipitated out easily in high yields.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 36315-01-2, 2-Amino-4,6-dimethoxypyrimidine.

Reference:
Article; Wu, Ren-Jun; Ren, Tongtong; Gao, Jie-Yu; Wang, Li; Yu, Qilin; Yao, Zheng; Song, Guo-Qing; Ruan, Wei-Bin; Niu, Cong-Wei; Song, Fu-Hang; Zhang, Li-Xin; Li, Mingchun; Wang, Jian-Guo; European Journal of Medicinal Chemistry; vol. 162; (2019); p. 348 – 363;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 36315-01-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 36315-01-2, name is 2-Amino-4,6-dimethoxypyrimidine. A new synthetic method of this compound is introduced below.

A sealed tube was charge with 21-2 (1 mmol), 21-3 (1 mmol) and sodium tert-butoxide (310 mmol) in toluene (5 mL). The resulting mixture was degassed with Argon for about 10 minutesfollowed by the addition ofPd2(dba)3 (0.1 mmol) and XantPhos (0.2 mmol). Reaction mixture washeated at 100C for 16 hours to produce 21-4(a-e). It was then cooled to room temperature, filteredthrough a cartridge and the filtrate was partitioned between ethyl acetate and water. Organic layerwas separated, washed with water, brine, dried over anhydrous Na2S04 and concentrated under15 reduced pressure. Crude mass was purified by column chromatography (silica, gradient: 0-25%ethyl acetate in hexane) to afford 21-4(a-e).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,36315-01-2, its application will become more common.

Reference:
Patent; C4 THERAPEUTICS, INC.; PHILLIPS, Andrew, J.; NASVESCHUK, Christoper, G.; HENDERSON, James, A.; LIANG, Yanke; HE, Minsheng; DUPLESSIS, Martin; CHEN, Chi-Li; (791 pag.)WO2018/237026; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 36315-01-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 36315-01-2, name is 2-Amino-4,6-dimethoxypyrimidine. A new synthetic method of this compound is introduced below.

150 ml round-bottomed Three bottles will amine class Compound (2.0 mmol) and DMAP (2. 5 mmol) was dissolved 10 ml dichloromethane or THF or DMF, at room temperature solution containing 0.43 g 3,4-dichloro-isothiazole carboxylic acid chloride (2.0 mmol) in 2 ml of methylene chloride solution was stirred overnight at room temperature after completion , the reaction mixture was diluted with dichloromethane, washed with water, the organic layer was collected, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give the product after column chromatography, eluted with a volume ratio of 10: 1 petroleum ether: 1-2 : ethyl acetate, with the resulting yield of pure calculation, depending on the yield of the amine range ranging from 16.4% to 88.7%; melting point determination of structural parameters and 1Eta NMR, etc; the chemical structure of the parameters in Table IV

At the same time, in my other blogs, there are other synthetic methods of this type of compound,36315-01-2, 2-Amino-4,6-dimethoxypyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Jiangxi Tianren Ecology Co., Ltd.; Nankai University; Chen, Xiaoyan; Liu, Xiping; Fan, Zhijin; Liang, Xiaowen; Li, Yuedong; Mao, Wutao; Li, Juanjuan; Wang, Dun; Wang, Shuhua; Zhou, Lifeng; Ji, Xiaotian; HUA, XUEWEN; (23 pag.)CN102942565; (2016); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 36315-01-2, Name is 2-Amino-4,6-dimethoxypyrimidine. In a document, author is Zhang, Rong, introducing its new discovery. Product Details of 36315-01-2.

Pyrimidine-thioindole inhibits gastric cancer cell proliferation via up-regulation of expression of tumor suppressor miR-145

Purpose: To investigate the effect of pyrimidine-thioindole on gastric cancer proliferation and the underlying mechanism of action. Methods: Cell viability and apoptosis were determined using MTT assay and Annexin V/P1 assay, respectively. Reverse transcription-polymerase chain reaction (RT-PCR) was used for the determination of expression levels of miR-145, while protein expression levels were assayed by western blotting. Results: Pyrimidine-thioindole treatment significantly inhibited the proliferation of AGS and SNU-5 cells (p < 0.05), but had no effect on the viability of GES-1 cells. Exposure to pyrimidine-thioindole at doses of 8 and 10 mu M significantly enhanced the apoptosis of AGS and SNU-5 cells (p < 0.05). Pyrimidine-thioindole exposure markedly increased the proportions of AGS and SNU-5 cells in G1 phase (p < 0.05). In AGS and SNU-5 cell lines, pyrimidine-thioindole exposure at doses of 8 and 10 mu M significantly upregulated the expression of miR-145, with higher enhancement of miR-145 expression in AGS cells than in SNU-5 cells. Moreover, pyrimidine-thioindole downregulated the expressions of MMP-2, MMP-9, c-Myc, p-PI3K and p-AKT in AGS and SNU-5 cells. Pyrimidine-thioindole treatment enhanced the expression of p21 in AGS and SNU-5 cells, relative to untreated cells (p < 0.05). Conclusion: These results suggest that pyrimidine-thioindole activates apoptotic signaling pathway, leading to reduction in cell proliferation and arrest of cell cycle. Moreover, it de-activates PI3K/AKT pathway and promotes miR-145 expression in AGS and SNU-5 cells. Thus, pyrimidine-thioindole has therapeutic significance for the management of gastric cancer. I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 36315-01-2 help many people in the next few years. Product Details of 36315-01-2.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia