Category: 36315-01-2

36315-01-2 , The common heterocyclic compound, 36315-01-2, name is 2-Amino-4,6-dimethoxypyrimidine, molecular formula is C6H9N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

REFERENTIAL EXAMPLE 1 Preparation of 2-chloro-4,6-dimethoxypyrimidine 1,260 ml of 36% hydrochloric acid were charged in a 5-l four-necked flask and then cooled to 0 C. After 180 g (1.16 moles) of 2-amino-4,6-dimethoxypyrimidine were added in small portions into the flask, the resulting mixture was stirred for about 1 hour until the reaction mixture changed into a syrupy form. After the reaction mixture was cooled to -15 C., 260 ml of 159 g (2.3 moles) of NaNO2 in H2 O were added dropwise over about 1 hour under vigorous stirring. After completion of the dropwise addition, the resulting mixture was stirred at -15 to -10 C. for additional 1 hour so that the reaction was brought to completion. While the reaction mixture was retained at -5 C., 1.5 l of a 30% aqueous solution of NaOH were charged dropwise so that the reaction mixture was neutralized to pH 7. By filtration under reduced pressure, a clay-like material of a purple color was collected. The target compound was extracted from the clay-like material using 3 l of ethyl acetate. Through the procedures of washing with water, drying over anhydrous sodium sulfate and removal of the solvent, 63 g of bluish crude crystals were obtained. They were crystallized further by silica gel chromatography to obtain 60.8 g of white crystals (yield: 29.9%). Melting point: 101.5-102.5 C.

According to the analysis of related databases, 36315-01-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Mitsui Toatsu Chemicals, Incorporated; US4986846; (1991); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 36315-01-2, name is 2-Amino-4,6-dimethoxypyrimidine. This compound has unique chemical properties. The synthetic route is as follows. 36315-01-2

STR163 A mixture of 15.5 g (0.1 mole) of 2-amino-4,6-dimethoxy-pyrimidine, 13.1 g (0.1 mole) of ethoxycarbonyl isothiocyanate and 200 ml of acetonitrile is stirred at 60 C. for 2 hours. It is then cooled to 10 C. and the product obtained as crystals is isolated by filtration with suction. 22.5 g (79% of theory) of 1-(ethoxycarbonyl)-3-(4,6-dimethoxy-pyrimidin-2-yl)-thiourea of melting point 194 C. (decomposition) are obtained.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 36315-01-2, 2-Amino-4,6-dimethoxypyrimidine.

Reference:
Patent; Bayer Aktiengesellschaft; US4658027; (1987); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 36315-01-2, name is 2-Amino-4,6-dimethoxypyrimidine, molecular formula is C6H9N3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 36315-01-2

To the reaction solution ethoxycarbonyl isothiocyanate of 2-amino-4,6-dimethoxy-pyrimidine 124.1g (0.8mol), control the temperature 40 , heat 6h, until starting 2-amino-4, 6- Dimethyloxy completion of the reaction, cooled to room temperature,filtration, and washed with 50mL ethyl acetate to give the product, wet weight of 400g,the product obtained after drying 192.9g, 98.5%, yield 84.3%.

The chemical industry reduces the impact on the environment during synthesis 36315-01-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Heilongjiang Kaiao Technology Development Co., Ltd.; GAO, JINSHENG; NIU, LIZHONG; ZUO, DIANFA; LIU, JILONG; MA, YICHAO; (23 pag.)CN105399746; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

36315-01-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 36315-01-2 as follows.

24.5g carbamate, 11.8g 4,6-dimethoxy-2-pyrimidinamine, 200mL tolueneMix and put into the reaction vessel and heat to reflux. After about 0.5h, start to collect the mixed solution of toluene and ethanol.Fresh toluene was added at the same speed, and the reaction was completed after refluxing for 5h. Stop adding toluene, distill off some toluene, cool to room temperature, and filter.After drying, 24.6 g of nicosulfuron was obtained, the mass fraction was 95.0%, and the yield was 75.6%.

The chemical industry reduces the impact on the environment during synthesis 36315-01-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Heilongjiang Suihua Farming Chenhuan Biological Preparation Co., Ltd.; Du Chuanyu; Zhao Mingxin; Jiang Yushan; Zhou Dewei; Wang Weisheng; (7 pag.)CN111269214; (2020); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia