Category: 36847-10-6

Adding a certain compound to certain chemical reactions, such as: 36847-10-6, 4,6-Dibromopyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 36847-10-6, blongs to pyrimidines compound. name: 4,6-Dibromopyrimidine

10292] In this example, a method of synthesizing an organic compound of one embodiment of the present invention, 5,5?- (4,6-pyrimidinediyldi-3, 1 -phenylene)bis-5H-benzothieno[3, 2-c]carbazole (abbreviation: 4,6mBTcP2Pm) (structural formula (112)), is described. Note that a structure of 4,6mBTcP2Pm is shown below. 10293] Into a 100-mE three-neck flask were put 0.75 g (3.2 mmol) of 4,6-dibromopyridine, 3.3 g (6.9 mmol) of2-[3-(5H- benzothieno[3,2-c]carbazol-5-yl)phenyl]-4,4,5,5-tetram- ethyl-1,3,2-dioxaborol ane, and 96mg (0.32 mmol) of tris(2- methylphenyl)phosphine. The air in the flask was replaced with nitrogen. To this mixture were added 7 mE of a 2M aqueous solution of potassium carbonate, 16 mE of toluene, and 5 mE of ethanol. The mixture was degassed by being stirred under reduced pressure. To this mixture, 14mg (0.062 mmol) of palladium(II) acetate was added. The mixture was stirred at 90 C. under a nitrogen stream for 16 hours.10294] After that, a precipitated solid was collected by suction filtration. Chloroform was added to this solid, and irradiation with ultrasonic waves was performed; then, a solid was collected by suction filtration. Toluene was added to this solid, and irradiation with ultrasonic waves was performed. A solid was collected by suction filtration to give 1.9 g of a brown solid, which was the object of the synthesis, in a yield of 79%.10295] The synthesis scheme of the above synthesis method is shown below in (D-1).10296] By a train sublimation method, 1.9 g of the obtained brown solid was purified. In the purification by sublimation, the brown solid was heated at 360 C. under the conditions where the pressure was 3.0 Pa and the argon flow rate was 5.0 mE/mm. Afier the purification by sublimation, 0.76 g ofyellow solid was obtained at a collection rate of 40%.10297] By a train sublimation method, 0.76 g of the obtained yellow solid was again purified. In the purification by sublimation, the yellow solid was heated at 360 C. under the conditions where the pressure was 3.0 Pa and the argon flow rate was 5.0 mE/mm. Afier the purification by sublimation, 0.58 g of a yellow solid was obtained at a collection rate of 90%.10298] Analysis results by nuclear magnetic resonance (?H-NMR) spectroscopy of the obtained yellow solid are described below. FIGS. 32A and 32B are ?H-NMR charts. The results show that the organic compound of one embodiment of the present invention, 4,6mBTcP2Pm (structural formula (112)), was obtained.10299] ?H-NMR (CDC13, 300 MHz): oe (ppm)=7.43-7.55 (m, 12H), 7.77-7.84 (m, 411), 7.99 (d, J=8.7 Hz, 2H), 8.16- 8.20 (m, 5H), 8.28-8.33 (m, 4H), 8.44 (s, 2H), 9.36 (d, J=0.9 Hz, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,36847-10-6, its application will become more common.

Reference:
Patent; Semiconductor Energy Laboratory Co., Ltd.; Mitsumori, Satomi; OHE, Yuko; HAMADA, Takao; (66 pag.)US2016/75718; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 36847-10-6, name is 4,6-Dibromopyrimidine. A new synthetic method of this compound is introduced below., HPLC of Formula: C4H2Br2N2

Synthesis Example 1 (0304) In this example, a method of synthesizing 9,9?-[pyrimidine-4,6-diyl bis(biphenyl-3,3?-diyl)]bis(9H-carbazole) (abbreviation: 4,6mCzBP2Pm) (the structural formula (100)), which is a heterocyclic compound of one embodiment of the present invention, is described. The structure of 4,6mCzBP2Pm is shown below. Synthesis of 4,6mCzBP2Pm (0305) First, 0.54 g (2.3 mmol) of 2,4-dibromopyrimidine, 1.8 g (5.0 mmol) of 3-(3-(9H-carbazol-9-yl)phenyl)phenyl boronic acid, and 69 mg (0.23 mmol) of tris(2-methylphenyl)phosphine were put into a 50-mL three-neck flask, and the air in the flask was replaced with nitrogen. (0306) Then, 4.9 mL of a 2M potassium carbonate aqueous solution, 12 mL of toluene, and 4 mL of ethanol were added to this mixture, and the mixture was degassed by being stirred under reduced pressure. To this mixture, 10 mg (0.045 mmol) of palladium(II) acetate was added and stirring was performed under a nitrogen stream at 90 C. for 16 hours. After the stirring, water was added to the mixture, and an aqueous layer was subjected to extraction with toluene. (0307) The obtained solution of the extract and an organic layer were combined, and the mixture was washed with water and saturated brine. Then, the mixture was dried with magnesium sulfate. This mixture was separated by gravity filtration, and the filtrate was concentrated to give an oily substance. The oily substance was purified by silica gel column chromatography (as the developing solvent, first hexane and toluene in a ratio of 5:1 were used, and then chloroform and ethyl acetate in a ratio of 50:1 were used). The obtained fraction was concentrated to give an oily substance. Chloroform was added to this oily substance, the mixture was suction-filtered through Celite and alumina, and the filtrate was concentrated to give an oily substance. This oily substance was purified by high performance liquid column chromatography (HPLC) (developing solvent: chloroform). (0308) The obtained fraction was concentrated to give an oily substance. This oily substance was recrystallized with toluene/hexane to give 1.0 g of a target white solid in a yield of 63%. (0309) By a train sublimation method, 0.99 g of the obtained white solid was purified. In the purification by sublimation, the white solid was heated at 320 C. under the conditions where the pressure was 2.7 Pa and the argon flow rate was 5 mL/min. After the purification by sublimation, 0.91 g of a pale yellow solid was obtained at a collection rate of 92%. A synthesis scheme of the above synthesis method is shown in (A-1) below. (0310) Analysis results by nuclear magnetic resonance (1H-NMR) spectroscopy of the pale yellow solid obtained by the above-described synthesis method are described below. FIGS. 15A and 15B show the 1H-NMR chart. FIG. 15B is a chart where the range from 7 (ppm) to 10 (ppm) on the horizontal axis (delta) in FIG. 15A is enlarged. The results revealed that 4,6mCzBP2Pm (the structural formula (100)), which is a heterocyclic compound of one embodiment of the present invention, was obtained in this example. (0311) 1H-NMR (CDCl3, 300 MHz): g=7.30 (td, J=7.2 Hz, 1.2 Hz, 4H), 7.39-7.50 (in, 8H), 7.59-7.66 (m, 4H), 7.72 (t, J=7.8 Hz, 2H), 7.78-7.83 (m, 4H), 7.89 (s, 2H), 8.13-8.20 (in, 7H), 8.45 (s, 2H), 9.34 (sd, J=1.2 Hz, 1H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 36847-10-6, 4,6-Dibromopyrimidine.

Reference:
Patent; Semiconductor Energy Laboratory Co., Ltd.; SEO, Satoshi; KUBOTA, Yuko; TAKAHASHI, Tatsuyoshi; MITSUMORI, Satomi; (77 pag.)US2016/308139; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 36847-10-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 36847-10-6, name is 4,6-Dibromopyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

4,6-dibromopyrimidine (300 mg) and 1-cyclopropylmethanamine (130 p1) were stirred in dioxane 1,4-dioxane (6.0 ml) for 2h at 110?C. The mixture was then concentrated under reduced pressure. The crude was solubilised in DCM and water was added. The aqueous phase was extracted two times with EtOAc. The organic phase was dried (silicone filter) andconcentrated under reduced pressure. The crude was used without further purification.LC-MS (Method 2): Rt 0.99 mm; MS (ESIpos): mlz = 228 [M+H]

According to the analysis of related databases, 36847-10-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; SCHULZE, Volker; HEINRICH, Tobias; PRINZ, Florian; LEFRANC, Julien; SCHROeDER, Jens; MENGEL, Anne; BONE, Wilhelm; BALINT, Joszef; WENGNER, Antje; EIS, Knut; IRLBACHER, Horst; KOPPITZ, Marcus; BOeMER, Ulf; BADER, Benjamin; BRIEM, Hans; LIENAU, Philip; CHRIST, Clara; STOeCKIGT, Detlef; HILLIG, Roman; (1256 pag.)WO2017/102091; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 36847-10-6, name is 4,6-Dibromopyrimidine. This compound has unique chemical properties. The synthetic route is as follows. name: 4,6-Dibromopyrimidine

35.7g in a dry 2L three-necked flask 4.6-dibromopyrimidine and 27.9 g 3-aminobiphenyl, Then dry and degassed 800 mL of toluene was added as a solvent. Add 43.2g of sodium tert-butoxide, 0.67g catalyst palladium acetate (2% mol) and 3.7g Ligand 1,1′-binaphthyl-2,2′-bisdiphenylphosphine (BINAP, 4% mol). The temperature was raised to 110C and the reaction ended overnight. Cool to room temperature, add activated carbon adsorption, suction filtration, remove solvent, Recrystallization from toluene and ethanol, 33.3 g of intermediate K was obtained (yield 68%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 36847-10-6, 4,6-Dibromopyrimidine.

Reference:
Patent; Nanjing Gao Guang Semiconductor Materials Co., Ltd.; Jin Zhenyu; Qian Chao; Gao Penghui; Wang Xiaowei; (62 pag.)CN107686484; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 36847-10-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 36847-10-6, name is 4,6-Dibromopyrimidine. A new synthetic method of this compound is introduced below.

To CH2Cl2 solution (20 mL) containing pmbNOH (25 mg; 0.10 mmol) was added excess Ag2O (ca. 1 mmol) with being stirred at room temperature. The mixture was stirred for further 20 min. Filtration followed by concentration under reduced pressure gave an oily product (pmbNO). The IR spectrum supports the absence of the hydroxyl group. IR (neat, ATR) 729, 860, 985, 1191, 1223, 1246, 1344, 1365, 1444, 1481, 1555, 2935, 2984 cm-1. The MS spectrum indicates the loss of two H atoms from the precursor. MS (ESI+-TOF in MeOH) m/z 275.16 [(M+Na)+]. At this stage, pmbNO could be characterized by means of ESR spectroscopy and SQUID magnetometry (see the main text). The resultant pmbNO was dissolved again in CH2Cl2 (20 mL) and covered with a hexane solution (5 mL) of anhydrous [Cu(hfac)2] (95 mg). After slow diffusion of the solutions, reddish brown plates of [Cu3(pmbNO)2(hfac)4]¡¤(C6H14) (10 mg; 12%) were grown and separated on a filter.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,36847-10-6, 4,6-Dibromopyrimidine, and friends who are interested can also refer to it.

Reference:
Article; Homma, Yuta; Okazawa, Atsushi; Ishida, Takayuki; Tetrahedron Letters; vol. 54; 24; (2013); p. 3120 – 3123;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia