Reference of 37131-89-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 37131-89-8, name is 2,4-Dichloropyrimidine-5-carboxylic acid. A new synthetic method of this compound is introduced below.
To a 50 ml three-necked flask was added successively the crude product (0.6 g, 3.1 mmol) in the previous step,Thionyl chloride (10 ml) and heated to 80 C for 4 hours.Concentrated to dryness under reduced pressure to give 0.6 g of 2,4-dichloro-5-pyrimidinecarboxylic acid chloride in a yield of 90%
At the same time, in my other blogs, there are other synthetic methods of this type of compound,37131-89-8, 2,4-Dichloropyrimidine-5-carboxylic acid, and friends who are interested can also refer to it.
Reference:
Patent; SUZHOU WANGSHAN WANGSHUI BIOMEDICAL CO LTD; TOPHARMAN SHANGHAI CO LTD; SHANDONG TOPHARMAN PHARMACEUTICAL CO LTD; TIAN, GUANGHUI; LI, JUNQI; (17 pag.)CN104650045; (2017); B;,
Pyrimidine | C4H4N2 – PubChem,
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