Category: 3740-92-9

Synthetic Route of 3740-92-9 ,Some common heterocyclic compound, 3740-92-9, molecular formula is C10H6Cl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

The title compound was prepared from 4,6-dichloro-2-phenyl-pyriinidine (Ig, 4.42 mmol) and 4-thiomethiotayl aniline (0.61 g, 4.42 mmol) in the presence of triethyl amine in n-butanol at refluxing temperature for 12 hours.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3740-92-9, its application will become more common.

Reference:
Patent; REDDY US THERAPEUTICS, INC.; KALLEDA, Srinivas; PADAKANTI, Srinivas; KUMAR SWAMY, Nalivela; YELESWARAPU, Koteswar, Rao; ALEXANDER, Christopher, W.; KHANNA, Ish, Kumar; IQBAL, Javed; PILLARISETTI, Sivaram; PAL, Manojit; BARANGE, Deepak; WO2006/34473; (2006); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 3740-92-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3740-92-9, name is 4,6-Dichloro-2-phenylpyrimidine, molecular formula is C10H6Cl2N2, molecular weight is 225.07, as common compound, the synthetic route is as follows.

EXAMPLE IX Seven grams of 4,6-dichloro-2-phenylpyrimidine is added in small portions to 30 ml. of beta-methoxyethylamine with slight warming and stirring. The resulting mixture is heated on a steam bath for several minutes and then poured into 500 ml. of water. The product thus obtained (5.1 g.) is recrystallized from n-heptane to afford 4-chloro-6-(2-methoxyethylamino)-2-phenylpyrimidine, 48.5°-50°C. Anal. for C13 H14 N3 OCl: Calcd. C, 59.21; H, 5.35; N, 15.93. Found: C, 59.32; H, 5.31; N, 15.72.

Statistics shows that 3740-92-9 is playing an increasingly important role. we look forward to future research findings about 4,6-Dichloro-2-phenylpyrimidine.

Reference:
Patent; American Home Products Corporation; US3940395; (1976); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 3740-92-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3740-92-9, name is 4,6-Dichloro-2-phenylpyrimidine, molecular formula is C10H6Cl2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

In 250mL three-necked flask, purged with nitrogen, was added 0.01mol intermediate A20, 150mlDMF, 0.012mol intermediate B1, 0.0001mol palladium acetate, stirred,Then 0.01mol K3PO4 aqueous solution was added, heated to 150 , the reaction was refluxed for 24 hours, the sample point plate, the reaction was complete.The mixture was naturally cooled and extracted with 200 ml of dichloromethane. The layers were separated and the extract was dried over anhydrous sodium sulfate and filtered. The filtrate was rotary evaporated and purified over silica gel to give intermediate C1. HPLC purity was 99.2percent with a yield of 85.1percent.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3740-92-9, 4,6-Dichloro-2-phenylpyrimidine.

Reference:
Patent; Jiangsu March Optoelectric Technology Co., Ltd.; Zhang Zhaochao; Li Chong; (51 pag.)CN107417668; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 3740-92-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3740-92-9, name is 4,6-Dichloro-2-phenylpyrimidine, molecular formula is C10H6Cl2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

In 250mL three-necked flask, purged with nitrogen, was added 0.01mol intermediate A20, 150mlDMF, 0.012mol intermediate B1, 0.0001mol palladium acetate, stirred,Then 0.01mol K3PO4 aqueous solution was added, heated to 150 , the reaction was refluxed for 24 hours, the sample point plate, the reaction was complete.The mixture was naturally cooled and extracted with 200 ml of dichloromethane. The layers were separated and the extract was dried over anhydrous sodium sulfate and filtered. The filtrate was rotary evaporated and purified over silica gel to give intermediate C1. HPLC purity was 99.2percent with a yield of 85.1percent.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3740-92-9, 4,6-Dichloro-2-phenylpyrimidine.

Reference:
Patent; Jiangsu March Optoelectric Technology Co., Ltd.; Zhang Zhaochao; Li Chong; (51 pag.)CN107417668; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 3740-92-9, 4,6-Dichloro-2-phenylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 4,6-Dichloro-2-phenylpyrimidine, blongs to pyrimidines compound. name: 4,6-Dichloro-2-phenylpyrimidine

EXAMPLE 6 This Example illustrates the preparation of (E)-methyl 2-[2-(6-chloro-2-phenylpyrimidin-4-yloxy)phenyl]-3-methoxypropenoate (Compound No.378 of Table II). A stirred solution containing (E)-methyl 2-(2-hydroxyphenyl)-3-methoxypropenoate (208mg) and 4,6-dichloro-2-phenylpyrimidine (225mg, prepared according to the method of D. B. Harden, M. J. Mokrose and L. Strekowski, J.Org.Chem, 1988, 53, 4137-4140) in DMF (5 ml) was cooled to 0° C. Potassium carbonate (138mg) was then added and stirring was continued at 0° C. under an atmosphere of nitrogen. After 3 hours, the temperature was allowed to rise to room temperature and stirring was continued overnight. The reaction mixture was diluted with water and then acidified with dilute hydrochloric acid. The resulting mixture was extracted with ether (*3) and the combined ether extracts were washed successively with dilute aqueous sodium hydroxide solution (*2) and water (*3) and then dried. Evaporation of the solvent gave an oil (0.31 g), which solidified on standing. Chromatography (eluent ether-hexane, 1:2) afforded the title compound (0.12 g, 30percent) as an off-white solid; m.p. 118-120° C.; 1H NMR: delta 3.54(3H,s), 3.67(3H,s), 6.65(1H,s), 7.22-7.50(7H,m), 7.44(1H,s), 8.28-8.33(2H,m) ppm; IR maxima: 1708, 1631 cm-1.

The synthetic route of 3740-92-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Clough, John Martin; Godfrey, Christopher Richard Ayles; Streeting, Ian Thomas; Cheetham, Rex; de Fraine, Paul John; Bartholomew, David; Eshelby, James John; US2003/60626; (2003); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 3740-92-9, 4,6-Dichloro-2-phenylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 4,6-Dichloro-2-phenylpyrimidine, blongs to pyrimidines compound. Application In Synthesis of 4,6-Dichloro-2-phenylpyrimidine

EXAMPLE 6 This Example illustrates the preparation of (E)-methyl 2-[2-(6-chloro-2-phenylpyrimidin-4-yloxy)phenyl]-3-methoxypropenoate (Compound No.378 of Table II). A stirred solution containing (E)-methyl 2-(2-hydroxyphenyl)-3-methoxypropenoate (208mg) and 4,6-dichloro-2-phenylpyrimidine (225mg, prepared according to the method of D. B. Harden, M. J. Mokrose and L. Strekowski, J.Org.Chem, 1988, 53, 4137-4140) in DMF (5 ml) was cooled to 0° C. Potassium carbonate (138mg) was then added and stirring was continued at 0° C. under an atmosphere of nitrogen. After 3 hours, the temperature was allowed to rise to room temperature and stirring was continued overnight. The reaction mixture was diluted with water and then acidified with dilute hydrochloric acid. The resulting mixture was extracted with ether (*3) and the combined ether extracts were washed successively with dilute aqueous sodium hydroxide solution (*2) and water (*3) and then dried. Evaporation of the solvent gave an oil (0.31 g), which solidified on standing. Chromatography (eluent ether-hexane, 1:2) afforded the title compound (0.12 g, 30percent) as an off-white solid; m.p. 118-120° C.; 1H NMR: delta 3.54(3H,s), 3.67(3H,s), 6.65(1H,s), 7.22-7.50(7H,m), 7.44(1H,s), 8.28-8.33(2H,m) ppm; IR maxima: 1708, 1631 cm-1.

The synthetic route of 3740-92-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Clough, John Martin; Godfrey, Christopher Richard Ayles; Streeting, Ian Thomas; Cheetham, Rex; de Fraine, Paul John; Bartholomew, David; Eshelby, James John; US2003/60626; (2003); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3740-92-9, name is 4,6-Dichloro-2-phenylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C10H6Cl2N2

4,6-Dichloro-2-phenylpyrimidine (5.0 g, 22.2 mmol) and NaOCH3 (3.6 g, 66.6 mmol) was stirred in methanol (500 mL) on an ice bath for 1 h, then brought to reflux for 7 h. After evaporation, the white solid was dissolved in DCM (100 mL) and washed with water. Evaporation of the organic phase yielded 8 (3.98 g, 81%) as a white solid. 1H NMR (CD3OD): delta 8.39-8.36 (m, 2H), 7.53-7.44 (m, 3H), 6.76 (s, 1H), 4.08 (s, 3H). 13C NMR (CD3OD): delta 172.3, 165.9, 162.2, 137.4, 132.6, 129.5, 129.5, 106.0, 55.0. MS calcd for C11H9ClN2O [M+H]+ 221.0, found: 221.0.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 3740-92-9, 4,6-Dichloro-2-phenylpyrimidine.

Reference:
Article; Lampa, Anna; Alogheli, Hiba; Ehrenberg, Angelica E.; Akerblom, Eva; Svensson, Richard; Artursson, Per; Danielson, U. Helena; Karlen, Anders; Sandstroem, Anja; Bioorganic and Medicinal Chemistry; vol. 22; 23; (2014); p. 6595 – 6615;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 3740-92-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3740-92-9, name is 4,6-Dichloro-2-phenylpyrimidine, molecular formula is C10H6Cl2N2, molecular weight is 225.07, as common compound, the synthetic route is as follows.

A mixture of 80 (0.25g, 1.11mmol) and IPA (3ml) was stirred for a while and then 2M methylamine in THF (1.39ml, 2.78mmol) was added thereto at 0 °C. The resulting mixture was back to room temperature under stirring for overnight. The reaction was quenched by water and then the mixture was extracted by ethyl acetate (30ml x 3). The residue was purified by flash column over silica gel (ethyl acetate: n-Hexane = 1 :4, Rf = 0.18) to afford 84 (0.22g, 90.23percent) as a pale yellow solid. 1H-NMR (300MHz, CDCl3): delta 3.02 (d, J= 4.2 Hz, 3H), 5.09 (br, 1H), 6.26 (s, 1H), 7.42-7.46 (m, 3H), 8.35-8.37 (m, 2H).

The chemical industry reduces the impact on the environment during synthesis 3740-92-9, I believe this compound will play a more active role in future production and life.

Reference:
Patent; TAIPEI MEDICAL UNIVERSITY; YEN, Yun; LIOU, Jing-Ping; CHEN, Chun-Han; (70 pag.)WO2017/15400; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3740-92-9, name is 4,6-Dichloro-2-phenylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C10H6Cl2N2

(1) 5 g of fenclorin, 6.1 g of potassium carbonate and 2.46 g of o-fluorophenol were dissolved in 50 mL of chloroform, and the reaction was stirred at 90 C.After 4 h of reaction, it was monitored by thin layer chromatography (developing agent was petroleum ether and dichloromethane, V petroleum ether: V dichloromethane = 3:1).Stop the reaction when there is no remaining material, and cool to room temperature;(2) pouring the reaction liquid obtained in the step (1) into water,A large amount of white solid was precipitated, stirred for 4 h, and filtered with suction to give a white solid. The white solid was subjected to column chromatography.V petroleum ether: V dichloromethane = 9:1) gave 2.21 g of 4-chloro-6-(2-fluorophenoxy)-2-phenylpyrimidine (I5) in a yield of 33.48%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 3740-92-9, 4,6-Dichloro-2-phenylpyrimidine.

Reference:
Patent; Hunan Agricultural Bio-technology Institute; Bai Lianyang; Deng Xile; Zheng Wenna; Zhou Xiaomao; Liu Sihong; (13 pag.)CN109897005; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

3740-92-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3740-92-9, name is 4,6-Dichloro-2-phenylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 1,3-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2(1H)-one (249 mg, 1 mmol), 4,6-dichloro-2-phenylpyrimidine (171 mg, 1.0 mmol), Pd(PPh3)4 (116 mg, 0.1 mmol), aqueous sodium carbonate (2.0 M, 1 mL, 2 mmol) in dioxane (5 mL) was stirred and heated at 100¡ã C. for 2 h. The reaction mixture was diluted with water and extracted with EtOAc (3*). The extracts were combined, washed with brine, dried (Na2SO4) and concentrated. The residue was purified by flash column chromatography (EA:Hex, 0-80percent) to provide the 173 mg (67percent) of the desired product as an off-white solid. 1H NMR (400 MHz, DMSO-d6) delta ppm 2.13 (s, 3 H) 3.61 (s, 3H) 7.51-7.66 (m, 4H) 8.01 (s, 1H) 8.29 (s, 1H) 8.49 (dd, J=7.83, 1.77 Hz, 2H) 8.87 (d, J=2.27 Hz, 1H). LCMS (M+H)+312.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 3740-92-9, 4,6-Dichloro-2-phenylpyrimidine.

Reference:
Patent; CELGENE QUANTICEL RESEARCH, INC.; Bennett, Michael John; Betancort, Juan Manuel; Boloor, Amogh; Kanouni, Toufike; Stafford, Jeffrey Alan; Veal, James Marvin; Wallace, Michael Brennan; (250 pag.)US2017/298040; (2017); A1;,
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