Reference of 37538-67-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 37538-67-3, name is Pyrido[3,2-d]pyrimidin-4(3H)-one. This compound has unique chemical properties. The synthetic route is as follows.
General procedure: Potassium hydride (KH, 30% in mineral oil, 4.0 g) was suspended in 50 mL of dimethylformamide (DMF). It was cooled in an ice-water bath, and solid 3H-quinazolin-4-one (4.3 g) was added in. After 30 min, a solution of oxirane 14 (3.5 g) in 10 mL of DMF was added in. The reaction mixture was then heated at 80 C for 8 h under nitrogen atmosphere. It was partitioned between ethyl acetate (75 mL) and water (75 mL), separated organic layer was washed with water (3 × 50 mL), then brine (50 mL), dried over anhydrous sodium sulfate, and evaporated in a rotary evaporator under reduced pressure to furnish the crude product. Silica gel flash chromatography (75% ethyl acetate in hexanes) furnished 15 as off white solid. Yield: 79%.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 37538-67-3, Pyrido[3,2-d]pyrimidin-4(3H)-one.
Reference:
Article; Zhu, Shuren; Chandrashekar, Gudise; Meng, Li; Robinson, Katie; Chatterji, Dipsanker; Bioorganic and Medicinal Chemistry; vol. 20; 2; (2012); p. 927 – 932;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia