37552-81-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 37552-81-1, name is 4-Chloro-6-(trifluoromethyl)pyrimidine, molecular formula is C5H2ClF3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
4-Chloro-6-trifluoromethylpyrimidine (200 mg, 1.10 mmol) was dissolved in a solution of ammonia in methanol (7 M, 2.4 mL, 16.80 mmol) and then the reaction mixture was heated at 120 C for 5 minutes using microwave irradiation. The mixture was concentrated under reduced pressure and the residue was partitioned between ethyl acetate (25 mL) and saturated aqueous sodium bicarbonate solution (10 mL). The layers were separated and the organic layer was washed with water (10 mL) and brine, dried over sodium sulfate, filtered, and concentrated under reduced pressure to provide 6-(trifluoromethyl)pyrimidin-4-amine. MS ESI calc’d. for C5H5F3N3 [M + H]+ 164, found 164. NMR (500 MHz, DMSOd-6) delta 8.47 (s, 1H), 7.52 (br s, 2H), 6.77 (s, 1H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 37552-81-1, 4-Chloro-6-(trifluoromethyl)pyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK SHARP & DOHME CORP.; MERCK CANADA INC.; ANTHONY, Neville, J.; ANDRESEN, Brian, M.; NORTHRUP, Alan, B.; CHILDERS, Kaleen, K.; DONOFRIO, Anthony; MILLER, Thomas, A.; LIU, Yuan; MACHACEK, Michelle, R.; WOO, Hyun Chong; SPENCER, Kerrie, B.; ELLIS, John Michael; ALTMAN, Michael, D.; ROMEO, Eric, T.; GUAY, Daniel; GRIMM, Jonathan; LEBRUN, Marie-Eve; ROBICHAUD, Joel, S.; WANG, Liping; DUBOIS, Byron; DENG, Qiaolin; WO2014/176210; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia