Category: 37972-24-0

N-Metallacycles from [Cp^*MX₂]₂ and Alkynylpyridines: Synthesis, Reaction Pathway, and Aromaticity was written by Teo, Jing Wei;Sridevi, Venugopal Shanmugham;Leong, Weng Kee. And the article was included in Organometallics in 2014.Electric Literature of C6H4N2 This article mentions the following:

The reaction of [Cp^*MX₂]₂ (M = Rh or Ir, X = Cl, Br, or I) with alkynylpyridines afforded halogen-substituted N-metallacyclic complexes. The reaction pathway has been examined through deuterium labeling and other experiments and computational studies and is proposed to proceed via halide dissociation followed by attack at the alkyne. These N-metallacycles exhibit aromaticity and undergo Sonogashira coupling reactions. In the experiment, the researchers used many compounds, for example, 2-Ethynylpyrimidine (cas: 37972-24-0Electric Literature of C6H4N2).

2-Ethynylpyrimidine (cas: 37972-24-0) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Electric Literature of C6H4N2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Metronidazole-triazole conjugates: Activity against Clostridium difficile and parasites was written by Jarrad, Angie M.;Karoli, Tomislav;Debnath, Anjan;Tay, Chin Yen;Huang, Johnny X.;Kaeslin, Geraldine;Elliott, Alysha G.;Miyamoto, Yukiko;Ramu, Soumya;Kavanagh, Angela M.;Zuegg, Johannes;Eckmann, Lars;Blaskovich, Mark A. T.;Cooper, Matthew A.. And the article was included in European Journal of Medicinal Chemistry in 2015.COA of Formula: C6H4N2 This article mentions the following:

Metronidazole has been used clin. for over 50 years as an antiparasitic and broad-spectrum antibacterial agent effective against anaerobic bacteria. However resistance to metronidazole in parasites and bacteria has been reported, and improved second-generation metronidazole analogs are needed. The copper-catalyzed Huigsen azide-alkyne 1,3-dipolar cycloaddition offers a way to efficiently assemble new libraries of metronidazole analogs. Several new metronidazole-triazole conjugates (Mtz-triazoles) have been identified with excellent broad spectrum antimicrobial and antiparasitic activity targeting Clostridium difficile, Entamoeba histolytica, and Giardia lamblia. Cross resistance to metronidazole was observed against stable metronidazole resistant C. difficile and G. lamblia strains. However for the most potent Mtz-triazoles, the activity remained in a therapeutically relevant window. In the experiment, the researchers used many compounds, for example, 2-Ethynylpyrimidine (cas: 37972-24-0COA of Formula: C6H4N2).

2-Ethynylpyrimidine (cas: 37972-24-0) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.COA of Formula: C6H4N2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Hemilabile MICN^{铏?/sup> ligands allow oxidant-free Au(I)/Au(III) arylation-lactonization of 绾?alkenoic acids was written by Font, Pau;Valdes, Hugo;Guisado-Barrios, Gregorio;Ribas, Xavi. And the article was included in Chemical Science in 2022.Name: 2-Ethynylpyrimidine This article mentions the following:}

Here authors describe the synthesis of two Au(I) complexes bearing bidentate hemilabile MICN^{铏?/sup> ligands ligands, [AuI(MICN铏?/sup>)Cl], and their ability to stabilize square-planar Au(III) species (MIC = mesoionic carbene). The presence of the hemilabile N-ligand contributed to stabilize the ensuing Au(III) species acting as a five-membered ring chelate upon its coordination to the metal center. The Au(III) complexes can be obtained either by using external oxidants or, alternatively, by means of feasible oxidative addition with strained biphenylene C_sp2-C_sp2 bonds as well as with aryl iodides. Based on the fundamental knowledge gained on the redox properties on these Au(I)/Au(III) systems, authors successfully develop a novel Au(I)-catalytic procedure for the synthesis of 绾?substituted 绾?butyrolactones through the arylation-lactonization reaction of the corresponding 绾?alkenoic acid. The oxidative addition of the aryl iodide, which in turn is allowed by the hemilabile nature of the MICN铏?/sup> ligand, is an essential step for this transformation. In the experiment, the researchers used many compounds, for example, 2-Ethynylpyrimidine (cas: 37972-24-0Name: 2-Ethynylpyrimidine).}

2-Ethynylpyrimidine (cas: 37972-24-0) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Name: 2-Ethynylpyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

A general asymmetric copper-catalysed Sonogashira C(sp³)-C(sp) coupling was written by Dong, Xiao-Yang;Zhang, Yu-Feng;Ma, Can-Liang;Gu, Qiang-Shuai;Wang, Fu-Li;Li, Zhong-Liang;Jiang, Sheng-Peng;Liu, Xin-Yuan. And the article was included in Nature Chemistry in 2019.Related Products of 37972-24-0 This article mentions the following:

Continued development of the Sonogashira coupling has made it a well established and versatile reaction for the straightforward formation of C-C bonds, forging the carbon skeletons of broadly useful functionalized mols. However, asym. Sonogashira coupling, particularly for C(sp³)-C(sp) bond formation, has remained largely unexplored. Here the authors demonstrate a general stereoconvergent Sonogashira C(sp³)-C(sp) cross-coupling of a broad range of terminal alkynes and racemic alkyl halides (>120 examples) that are enabled by copper-catalyzed radical-involved alkynylation using a chiral cinchona alkaloid-based P,N-ligand. Industrially relevant acetylene and propyne are successfully incorporated, laying the foundation for scalable and economic synthetic applications. The potential utility of this method is demonstrated in the facile synthesis of stereoenriched bioactive or functional mol. derivatives, medicinal compounds and natural products that feature a range of chiral C(sp³)-C(sp/sp²/sp³) bonds. This work emphasizes the importance of radical species for developing enantioconvergent transformations. In the experiment, the researchers used many compounds, for example, 2-Ethynylpyrimidine (cas: 37972-24-0Related Products of 37972-24-0).

2-Ethynylpyrimidine (cas: 37972-24-0) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Related Products of 37972-24-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Photoelectron spectra and electronic structures of substituted pyrimidines was written by Lottermoser, Ursula;Rademacher, Paul;Mazik, Monika;Kowski, Klaus. And the article was included in European Journal of Organic Chemistry in 2005.Related Products of 37972-24-0 This article mentions the following:

The electronic structures of pyrimidine and its substituted derivatives were studied by UPS and quantum chem. methods. The ionization potentials corresponding to the 锜?MOs 锜?sub>1-锜?sub>3 and the two n_N orbitals of the pyrimidine unit could be determined and assigned for all compounds Multiple linear regression analyses of the IPs related to these orbitals with different substituent constants indicated that Hammett 锜?sub>P values performed well for all these IPs, whereas the resonance parameters R and R⁺ were satisfactory for 锜?and poor for n_N ionizations. In the experiment, the researchers used many compounds, for example, 2-Ethynylpyrimidine (cas: 37972-24-0Related Products of 37972-24-0).

2-Ethynylpyrimidine (cas: 37972-24-0) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Related Products of 37972-24-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Metronidazole-triazole conjugates: Activity against Clostridium difficile and parasites was written by Jarrad, Angie M.;Karoli, Tomislav;Debnath, Anjan;Tay, Chin Yen;Huang, Johnny X.;Kaeslin, Geraldine;Elliott, Alysha G.;Miyamoto, Yukiko;Ramu, Soumya;Kavanagh, Angela M.;Zuegg, Johannes;Eckmann, Lars;Blaskovich, Mark A. T.;Cooper, Matthew A.. And the article was included in European Journal of Medicinal Chemistry in 2015.COA of Formula: C6H4N2 This article mentions the following:

Metronidazole has been used clin. for over 50 years as an antiparasitic and broad-spectrum antibacterial agent effective against anaerobic bacteria. However resistance to metronidazole in parasites and bacteria has been reported, and improved second-generation metronidazole analogs are needed. The copper-catalyzed Huigsen azide-alkyne 1,3-dipolar cycloaddition offers a way to efficiently assemble new libraries of metronidazole analogs. Several new metronidazole-triazole conjugates (Mtz-triazoles) have been identified with excellent broad spectrum antimicrobial and antiparasitic activity targeting Clostridium difficile, Entamoeba histolytica, and Giardia lamblia. Cross resistance to metronidazole was observed against stable metronidazole resistant C. difficile and G. lamblia strains. However for the most potent Mtz-triazoles, the activity remained in a therapeutically relevant window. In the experiment, the researchers used many compounds, for example, 2-Ethynylpyrimidine (cas: 37972-24-0COA of Formula: C6H4N2).

2-Ethynylpyrimidine (cas: 37972-24-0) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.COA of Formula: C6H4N2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

N-Metallacycles from [Cp^*MX₂]₂ and Alkynylpyridines: Synthesis, Reaction Pathway, and Aromaticity was written by Teo, Jing Wei;Sridevi, Venugopal Shanmugham;Leong, Weng Kee. And the article was included in Organometallics in 2014.Electric Literature of C6H4N2 This article mentions the following:

The reaction of [Cp^*MX₂]₂ (M = Rh or Ir, X = Cl, Br, or I) with alkynylpyridines afforded halogen-substituted N-metallacyclic complexes. The reaction pathway has been examined through deuterium labeling and other experiments and computational studies and is proposed to proceed via halide dissociation followed by attack at the alkyne. These N-metallacycles exhibit aromaticity and undergo Sonogashira coupling reactions. In the experiment, the researchers used many compounds, for example, 2-Ethynylpyrimidine (cas: 37972-24-0Electric Literature of C6H4N2).

2-Ethynylpyrimidine (cas: 37972-24-0) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Electric Literature of C6H4N2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Gas- and liquid-phase C-H acidity of terminal acetylenes was written by Tupitsyn, I. F.;Popov, A. S.;Shibaev, A. Yu.. And the article was included in Zhurnal Obshchei Khimii in 1992.Safety of 2-Ethynylpyrimidine This article mentions the following:

Both corrected AM1 and MINDO/3 methods constituted acceptable approximations for calculation of proton affinity of ethynyde carbanions. Decrease in heat of deprotonation along the series H_nXCCH (X = 2nd period element C, N, O, F) testifies to the predominant role of electronegativity in C-H acidity; bond-length variations along this series, however, indicate repulsive interactions between the carbanion center and heteroatom. Carbanion stability increases (proton affinity decreases) upon 2nd- to 3rd row exchange, e.g., from H₃CCC^– to H₃SiCC^–; that this stabilization originates in dπ-conjugation is substantiated by decreasing Si-C bond length in the carbanion vs. acid. Heat of deprotonation decreases from HCCH to RCCH (R = aryl, N-containing heteroaryl) regardless of the degree of electron deficiency or electron excess in the ring. Correlations of heat of deprotonation with exptl. pK_a (thermodn. acidity) and k_D (kinetics of H-D exchange, as measure of kinetic acidity) were discussed. In the experiment, the researchers used many compounds, for example, 2-Ethynylpyrimidine (cas: 37972-24-0Safety of 2-Ethynylpyrimidine).

2-Ethynylpyrimidine (cas: 37972-24-0) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Safety of 2-Ethynylpyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Gas- and liquid-phase C-H acidity of terminal acetylenes was written by Tupitsyn, I. F.;Popov, A. S.;Shibaev, A. Yu.. And the article was included in Zhurnal Obshchei Khimii in 1992.Safety of 2-Ethynylpyrimidine This article mentions the following:

Both corrected AM1 and MINDO/3 methods constituted acceptable approximations for calculation of proton affinity of ethynyde carbanions. Decrease in heat of deprotonation along the series H_nXCCH (X = 2nd period element C, N, O, F) testifies to the predominant role of electronegativity in C-H acidity; bond-length variations along this series, however, indicate repulsive interactions between the carbanion center and heteroatom. Carbanion stability increases (proton affinity decreases) upon 2nd- to 3rd row exchange, e.g., from H₃CCC^– to H₃SiCC^–; that this stabilization originates in dπ-conjugation is substantiated by decreasing Si-C bond length in the carbanion vs. acid. Heat of deprotonation decreases from HCCH to RCCH (R = aryl, N-containing heteroaryl) regardless of the degree of electron deficiency or electron excess in the ring. Correlations of heat of deprotonation with exptl. pK_a (thermodn. acidity) and k_D (kinetics of H-D exchange, as measure of kinetic acidity) were discussed. In the experiment, the researchers used many compounds, for example, 2-Ethynylpyrimidine (cas: 37972-24-0Safety of 2-Ethynylpyrimidine).

2-Ethynylpyrimidine (cas: 37972-24-0) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Safety of 2-Ethynylpyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia