Category: 37972-24-0

Adding a certain compound to certain chemical reactions, such as: 37972-24-0, 2-Ethynylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 2-Ethynylpyrimidine, blongs to pyrimidines compound. Application In Synthesis of 2-Ethynylpyrimidine

General procedure: To a stirring solution of 3 (1 eq.) in MeOH (5 vol) was added alkyne(1 eq.) followed by 100 mM aq. CuSO4 (5 mol %) and 100 mM aq. sodium ascorbate (10 mol %). The reaction was poured into water (20 mL) and extracted with DCM (4 x 50 mL). The combined organics were washed with brine (50 mL), dried over anh. MgSO4 and filtered. The volatiles were removed in vacuo and the crude was purified by MPLC over C18 silica gel (Grace Reveleris X2, A: H2O+ 0.1% TFA, B: ACN + 0.1% TFA, 5-25%) then repurified (GraceReveleris X2, A: H2O + 0.1% TFA, B: ACN + 0.1% TFA, 5-100% B) togive a cream powder (16 mg, 9%). LCMS: Rt = 2.21 min, 99 A% 254nm, [M + H]+= 300.8. 1HNMR (600 MHz, DMSO-d6) delta 8.88 – 8.84 (m, 2H), 8.69 (s, 1H),8.06 (s, 1H), 7.44 (t, J = 4.9 Hz, 1H), 4.93 (dd, J = 6.5, 4.4Hz, 2H), 4.80 (dd, J = 6.6, 4.4 Hz, 2H), 1.93 (s, 3H). 13CNMR (150 MHz, DMSO-d6) delta 158.3, 157.8, 151.1,146.5, 138.4, 133.2, 127.3, 120.2, 48.9, 46.0, 12.9. HRMS calcd for C12H12N8NaO2 [M + Na]+, 323.0975; found, 323.0976.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,37972-24-0, 2-Ethynylpyrimidine, and friends who are interested can also refer to it.

Reference:
Article; Jarrad, Angie M.; Karoli, Tomislav; Debnath, Anjan; Tay, Chin Yen; Huang, Johnny X.; Kaeslin, Geraldine; Elliott, Alysha G.; Miyamoto, Yukiko; Ramu, Soumya; Kavanagh, Angela M.; Zuegg, Johannes; Eckmann, Lars; Blaskovich, Mark A.T.; Cooper, Matthew A.; European Journal of Medicinal Chemistry; vol. 101; (2015); p. 96 – 102;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 37972-24-0, name is 2-Ethynylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Formula: C6H4N2

To a solution of 226(100mg, 0.282mnmoi) and 4(58.8mg, 0565mmo1) in 2OmnL of Et3N was added Pd(PPh3)2C12 (9.91mg, 0.Ol4mmol) and CuT (5.38mg, 0.O28mmol). The mixture was protected with N2 atmosphere, then was heated at 70°C for 4 hours. TLC analysis showed complete conversion of starting material to a major product. The reaction mixture was thenconcentrated in vacuo. The crude product was purified by Prep-HPLC to give the target productCompound 93(20mg, yield: 21.44percent).LCMS: m/z 33 1 (M+H1H NMR (400 MHz, CDCI3): oe 8.76 (d, J 5.2 Hz, 2H), 8.21 (d, J= 0.8 Hz, IH), 7.98 (s, IH),773 (d, J == 9.2 Hz, 2H), 7.36-7.34 (m, 2H), 726 (d, J= 9.6 Hz, 11-I).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 37972-24-0, 2-Ethynylpyrimidine.

Reference:
Patent; HUA MEDICINE (SHANGHAI) LTD.; CHEN, Li; JIN, Xiaowei; (176 pag.)WO2017/117708; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 37972-24-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 37972-24-0, name is 2-Ethynylpyrimidine, molecular formula is C6H4N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 223(200mg, 0.694mmol) and 4(80mg, 0.764mmol) in 2OmL of Et3N was addedPd(PPh3)2C12 (24.37mg, 0.O3SmrnoI) and CuT (13.22mg, 0.O69mmol). The mixture wasprotected under N2 atmosphere, then was heated at 70¡ãC for 24 hours. TLC analysis showed complete conversion of starting material to a major product. The reaction mixture was then concentrated in vacuo. The crude product was purified by Prep-HPLC to give the target product Compound 86(18mg, yield c. 80 percent,).LCMS: m/ 265 (M+H)?H N?Ik (400 Mhz ( D( i) cS 8 5 (d J 49 lIz, 211) 8 16 (s, 111) 96 (s ill) 69- 61 (m, 2H), 725-7.22 (in, 1H), 7.22-7.11 (m, 2H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 37972-24-0, 2-Ethynylpyrimidine.

Reference:
Patent; HUA MEDICINE (SHANGHAI) LTD.; CHEN, Li; JIN, Xiaowei; (176 pag.)WO2017/117708; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.37972-24-0, name is 2-Ethynylpyrimidine, molecular formula is C6H4N2, molecular weight is 104.11, as common compound, the synthetic route is as follows.Application In Synthesis of 2-Ethynylpyrimidine

To a solution of 235(100mg, 0.272rnrnoi) and 4(56.6mg, 0543mmo1) in 2OrnL of Et3N was added Pd(PPh3)2C12 (9.53mg, 0.0 i4mmol) and Cui (5.17mg, 0.O27mmol). The mixture was protected with N2 atmosphere, then was heated at 70¡ãC for 4 hours. TLC analysis showedcomplete conversion of starting material to major product. The reaction mixture was then concentrated in vacuo. The crude product was purified by Prep-HPLC to give the target product Compound 133(24mg, yield: 25.7percent).LCMS: m/z 345 (M+HY;111 NMR (400 MHz, CDCI3): oe 8.76 (d, J= 4.0 Hz, 2H), 754 . 7.52. (m, 211), 7.35 7.32 (m,211), 7 25 (t J 4 6 Hz 1TI) 6 52 (d, / 0 4 lTz 111), 2 P (d, 1 0 4 Hz, 311)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,37972-24-0, 2-Ethynylpyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; HUA MEDICINE (SHANGHAI) LTD.; CHEN, Li; JIN, Xiaowei; (176 pag.)WO2017/117708; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 37972-24-0, Adding some certain compound to certain chemical reactions, such as: 37972-24-0, name is 2-Ethynylpyrimidine,molecular formula is C6H4N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 37972-24-0.

To a solution of 229(100mg, 0347mmo1) and 4(723mg, 0.694mmo1) in 2OmL of Et3N was added Pd(PPh3)2C12 (12.18mg, 0Oi7mmoi) and CuT (661mg, 0O35minoi). The mixture wasprotected with N2 atmosphere, then was heated at 70¡ãC for 24 hours. TLC analysis showed complete conversion of starting material to a major product. The reaction mixture was then concentrated in vacuo. The crude product was purified by Prep-HPLC to give the target product Compound 117(18mg, yield: 1962percent).LCNIS: rn/z 265 (M*H)t?H NMR (400 MHz, CDCI3): 5 8.77 (d, J 4.8 Hz, 2H), 7.87 (d, J= 2.4 Hz, 1H), 771-768 (m, 2H, 7.28-7.26 (m, IH), 7.19-7.15 (m, 2H), 679 (d, J= 2.8 Hz, IH).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 37972-24-0, 2-Ethynylpyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; HUA MEDICINE (SHANGHAI) LTD.; CHEN, Li; JIN, Xiaowei; (176 pag.)WO2017/117708; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia