Category: 38275-55-7

Electric Literature of 38275-55-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 38275-55-7, name is 5-Fluoropyrimidine-2-carbonitrile, molecular formula is C5H2FN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Method 5; l-(5-Fluoropyrimidin-2-yl)ethanone; A round-bottom-flask containing 5-fluoropyrimidine-2-carbonitrile (Method 6, 1.50 g,12.19 mmol) was charged with anhydrous THF (30 ml) under N2. The solution was cooled to 0 0C, and a solution of MeMgBr (4.90 ml of a 3.0 M solution in ether, 14.62 mmol) was added dropwise. After 2 hours at 0 0C, the reaction mixture was quenched with ice water and extracted with EtOAc. The organic extract was washed with brine, dried over Na2SO4, and evaporated to dryness to give the title compound as an oil (0.778 g, yield 46%). GC-MS, 140 (M); 1HNMR (CDCl3) delta 8.65 (s, 2H), 2.65 (s, 2H).

According to the analysis of related databases, 38275-55-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/49041; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 38275-55-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 38275-55-7 as follows.

Intermediate 5; l-(5-Fluoropyrimidin-2-yl)ethanoneTo a solution of 5-fluoropyrimidine-2-carbonitrile (Intermediate 4, 2.5 g) in Et2O (50 ml) at 00C was added drop-wise a solution of MeMgBr (12 ml, 3.0M in Et2O). The resulting solution was stirred at this temperature for 30 minutes, and was then allowed to warm to ambient temperature overnight. The mixture was quenched with a solution of saturated NH4Cl(aq) and extracted with Et2O. The organic extracts dried and evaporation gave a colored residue. Purification by column chromatography (ISCO, 3% MeOH/DCM) to afford the title compound (800 mg). 1H NMR (CDCl3) delta 8.75 (s, 2H), 2.77 (s, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,38275-55-7, its application will become more common.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/7753; (2009); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 38275-55-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 38275-55-7, name is 5-Fluoropyrimidine-2-carbonitrile, molecular formula is C5H2FN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A round-bottom-flask containing 5-fluoropyrimidine-2-carbonitrile (Method 59, 1.50 g, 12.19 mmol) was charged with anhydrous THF (30 ml) under N2. The solution was cooled to 0 C, and a solution of MeMgBr (4.90 ml of a 3.0 M solution in ether, 14.62 mmol) was added dropwise. After 2 hours at 0 C, the reaction mixture was quenched with ice water and extracted with EtOAc. The organic extract was washed with brine, dried over Na2SO4, and evaporated to dryness to give the title compound as an oil (0.778 g, yield 46%). GC-MS, 140 (M); 1H NMR (CDCl3) delta 8.65 (s, 2H), 2.65 (s, 2H).

According to the analysis of related databases, 38275-55-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/82392; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 38275-55-7, name is 5-Fluoropyrimidine-2-carbonitrile. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 38275-55-7

Intermediate F, step a: methyl 5-fluoropyrimidine-2-carboxylate To a solution of 5-fluoropyrimidine-2-carbonitrile (513 mg, 4.17 mmol) in MeOH (5 mL) was added 5 mL of concentrated HCl. The mixture was stirred at 80 C. for 2 h. The solution was allowed to cool to room temperature and then treated with a small amount of saturated aqueous NaHCO3 solution and a larger amount of solid NaHCO3. The solution was used to keep everything homogeneous. When the pH reached 6-7 the aqueous layer was extracted with 10% EtOAc/DCM. The combined organic layers containing the ester were dried over Na2SO4. The aqueous layer was acidified to pH 3-4 with 1N HCl and then extracted with 10% EtOAc/DCM to afford the acid. The ester layer was filtered, concentrated in vacuo to a white solid (460 mg, 71%). MS (ESI): mass calcd. C6H5FN2O2, 156.03; m/z found, 157.1 [M+H]+. 1H NMR (500 MHz, CDCl3): 8.80 (s, 2H), 4.07 (s, 3H).

With the rapid development of chemical substances, we look forward to future research findings about 38275-55-7.

Reference:
Patent; Janssen Pharmaceutica NV; Letavic, Michael A.; Rudolph, Dale A.; US2014/275056; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 38275-55-7, name is 5-Fluoropyrimidine-2-carbonitrile. A new synthetic method of this compound is introduced below., Computed Properties of C5H2FN3

To a mixture of 1-ethyl-7-fluoro-6-methoxy-1,2,3,4-tetrahydroisoquinoline (0.3 g, 1.43 mmol) and 5-fluoropyrimidine-2-carbonitrile (0.26 g, 2.15 mmol) in DMF (8 mL) was added cesium carbonate (1.4 g, 4.3 mmol) under N2. The mixture was stirred at 100 C for 12 hours. The reaction mixture was cooled to rt, diluted with H2O (30 mL) and extracted with EtOAc (3 x 30 mL). The combined organic phase was washed with saturated aqueous brine solution (30 mL), dried over anhydrous sulfate, filtered and concentrated in vacuum. The residue was purified via normal phase SiO2 chromatography (0-20% EtOAc/petroleum ether) to give 5-(1-ethyl-7-fluoro-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl) pyrimidine-2- carbonitrile as a yellow solid (0.2 g, 45% yield, m/z: 313 [M+H]+ observed). 1H NMR (400 MHz, CDCl3) d 8.31 (s, 2H), 6.89 (d, J = 10.8 Hz, 1H), 6.80 (d, J = 8 Hz, 1H), 4.54 (t, J = 7.6 Hz, 1H), 3.90 (s, 3H), 3.73-3.67 (m, 1H), 3.61-3.54 (m, 1H), 3.03 (t, J = 6 Hz, 2H), 2.00-1.93 (m, 1H), 1.81-1.74 (m, 1H), 1.01 (t, J = 7.6 Hz, 3H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 38275-55-7, 5-Fluoropyrimidine-2-carbonitrile.

Reference:
Patent; ARBUTUS BIOPHARMA, INC.; CHEN, Shuai; COLE, Andrew G.; DORSEY, Bruce D.; DUGAN, Benjamin J.; FAN, Yi; GOTCHEV, Dimitar B.; KAKARLA, Ramesh; QUINTERO, Jorge; SOFIA, Michael J.; (220 pag.)WO2019/222238; (2019); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 38275-55-7, 5-Fluoropyrimidine-2-carbonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 5-Fluoropyrimidine-2-carbonitrile, blongs to pyrimidines compound. name: 5-Fluoropyrimidine-2-carbonitrile

Method 5; l-(5-Fluoropyrimidin-2-yl)ethanone; A round-bottom-flask containing 5-fluoropyrimidine-2-carbonitrile (Method 6, 1.50 g,12.19 mmol) was charged with anhydrous THF (30 ml) under N2. The solution was cooled to 0 0C, and a solution of MeMgBr (4.90 ml of a 3.0 M solution in ether, 14.62 mmol) was added dropwise. After 2 hours at 0 0C, the reaction mixture was quenched with ice water and extracted with EtOAc. The organic extract was washed with brine, dried over Na2SO4, and evaporated to dryness to give the title compound as an oil (0.778 g, yield 46%). GC-MS, 140 (M); 1HNMR (CDCl3) delta 8.65 (s, 2H), 2.65 (s, 2H).

The synthetic route of 38275-55-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/49041; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.38275-55-7, name is 5-Fluoropyrimidine-2-carbonitrile, molecular formula is C5H2FN3, molecular weight is 123.0879, as common compound, the synthetic route is as follows.Product Details of 38275-55-7

To a solution of 5-fluoropyrimidine-2-carbonitrile (Intermediate 1, 1.0 g, 8.1 mmol) in anhydrous THF at -780C was added a solution of DIBAL-H (8.1 mL) over a period of 20 minutes. The resulting mixture was stirred at this temperature for 2hours whereupon MeOH was added. The solution was allowed to warm to room temperature whereupon a solution of concentrated HCl was added. The resulting mixture was stirred for 2 hours at ambient temperature and the aqueous layer was washed with EtOAc (3x). The combined organic extracts were washed with brine and dried (MgSO4). Evaporation of the solvent afforded the titled compound (780 mg, 76%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,38275-55-7, 5-Fluoropyrimidine-2-carbonitrile, and friends who are interested can also refer to it.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2008/117050; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 38275-55-7, 5-Fluoropyrimidine-2-carbonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C5H2FN3, blongs to pyrimidines compound. Computed Properties of C5H2FN3

Method 12; N-(l-(5-Fluoropyrimidin-2-yl)vinyl)acetamide; 5-Fluoropyrimidine-2-carbonitrile (Method 6, 1.0 g, 8.1 mmol) in THF (10 ml) was added a solution of MeMgBr (3.3 ml, 9.75 mmol) in ether drop wise at 0 0C. After addition, the reaction was warmed to room temperature, stirred at room temperature for 1 hour and then diluted with DCM (10 ml). Acetic anhydride (1.23 ml, 13.0 mmol) was added in one portion. The reaction was stirred at room temperature for 1 hour and 40 0C for 1 hour. Saturated sodium bicarbonate solution (10 ml) was added and extracted with EtOAc (2×20 ml). The combined organic was dried over sodium sulfate. After removal of solvent, the resulted residue was purified by column chromatography (hexane-EtOAc = 2.5 : 1) to give the title compound as a white solid (0.38 g, 26%). 1H nuMR (400 MHz) 9.34 (s, IH), 8.95 (s, 2H), 6.25 (s, IH), 6.03 (s, IH), 2.11 (s, 3H). MS: Calcd.: 181; Found: [M+H]+ 182.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,38275-55-7, 5-Fluoropyrimidine-2-carbonitrile, and friends who are interested can also refer to it.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/49041; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 38275-55-7, Adding some certain compound to certain chemical reactions, such as: 38275-55-7, name is 5-Fluoropyrimidine-2-carbonitrile,molecular formula is C5H2FN3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 38275-55-7.

Intermediate 9N-( 1 -(5-Fluoropyrimidin-2-yl)vinyl)acetamide; 5-Fluoropyrimidine-2-carbonitrile (Intermediate 8, 1.0 g, 8.1 mmol) in THF (10 ml) was added a solution of MeMgBr (3.3 ml, 9.75 mmol) in ether drop wise at 0 0C. After addition, the reaction was warmed to room temperature, stirred at room temperature for 1 hour and then diluted with DCM (10 ml). Acetic anhydride (1.23 ml, 13.0 mmol) was added in one portion. The reaction was stirred at room temperature for 1 hour and 40 0C for 1 hour. Saturated sodium bicarbonate solution (10 ml) was added and extracted with EtOAc (2×20 ml). The combined organic was dried over sodium sulfate. After removal of solvent, the resulted residue was purified by column chromatography (hexane : EtOAc = 2.5 : 1) to give the title compound as a white solid (0.38 g, 26%). 1H NMR (400 MHz) 9.34 (s, IH), 8.95 (s, 2H), 6.25 (s, IH), 6.03 (s, IH), 2.11 (s, 3H). MS: Calculated: 181; Found: [M+H]+ 182.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 38275-55-7, 5-Fluoropyrimidine-2-carbonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2008/135786; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 38275-55-7, 5-Fluoropyrimidine-2-carbonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C5H2FN3, blongs to pyrimidines compound. Formula: C5H2FN3

Method 50; 5-Fluoropyrimidine-2-carbaldehvde; To a solution of 5-fluoropyrimidine-2-carbonitrile (Method 6, 1.0 g, 8.1 mmol) in anhydrous TetaF at -780C was added a solution of DIBAL-eta (8.1 mL) over a period of 20 minutes. The resulting mixture was stirred at this temperature for 2hours whereupon MeOH was added. The solution was allowed to warm to room temperature whereupon a solution of cone. HCl was added. The resulting mixture was stirred for 2 hours at ambient temperature and the aqueous layer was washed with EtOAc (3x). The combined organic extracts were washed with brine and dried (MgSO4). Evaporation of the solvent afforded the titled compound (780 mg, 76%). MS: [M+eta]+ 127.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,38275-55-7, 5-Fluoropyrimidine-2-carbonitrile, and friends who are interested can also refer to it.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/49041; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia