Category: 38275-61-5

Budesinsky, Zdenek et al. published their research in Collection of Czechoslovak Chemical Communications in 1972 | CAS: 38275-61-5

5-Chloropyrimidine-2-carboxylic acid (cas: 38275-61-5) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Application of 38275-61-5

Nucleophilic substitutions in the 2-methane sulfonylpyrimidine series was written by Budesinsky, Zdenek;Vavrina, Josef. And the article was included in Collection of Czechoslovak Chemical Communications in 1972.Application of 38275-61-5 This article mentions the following:

Oxidation of 5-substituted 2-methylthiopyrimidines gave the 2-methylsulfonyl derivatives, the nucleophilic substitution of which with NaOMe, N2H4, PhCH2NH2, NaCN, NaSH, and NaCH(CN)CO2Me gave the appropriate 5-substituted 2-methoxy-, 2-mercapto-, 2-hydrazino, 2-benzylamino-, 2-cyano-, and 2-(methoxycarbonylcyano-methyl)pyrimidine. 2-Methylsulfonyl-5-fluoropyrimidine (I) treated at 0闁?with NaOMe gave 2-methoxy-5-fluoropyrimidine but at a higher temperature and with excess NaOMe, 2,5-dimethoxypyrimidine was formed. I and N2H4 gave 5-hydrazino-2-meth-ylsulfonylpyrimidine. 5-Benzylamino-2-methylsulfonylpyri-midine was prepared analogously. At 10-20闁? the reaction of 2 methylsulfonyl-5-halo(fluoro, chloro, bromo)pyrimidines with-NaCN gave the 2-cyano derivatives but at a higher temperature, 2-cyano-5-methylsulfonylpyrimidine was formed. 2-Cyano-5-methylpyrimidine, 2-cyano-5-methoxypyrimidine, 2-cyano-5-fluoropyrimidine, 2-cyano-5-chloropyrimidine, and 2-cyano-5-bromopyrimidine exhibited an intensive sweet taste. In the experiment, the researchers used many compounds, for example, 5-Chloropyrimidine-2-carboxylic acid (cas: 38275-61-5Application of 38275-61-5).

5-Chloropyrimidine-2-carboxylic acid (cas: 38275-61-5) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Application of 38275-61-5

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Hilpert, Hans et al. published their research in Journal of Medicinal Chemistry in 2013 | CAS: 38275-61-5

5-Chloropyrimidine-2-carboxylic acid (cas: 38275-61-5) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Reference of 38275-61-5

灏?Secretase (BACE1) Inhibitors with High in Vivo Efficacy Suitable for Clinical Evaluation in Alzheimer’s Disease was written by Hilpert, Hans;Guba, Wolfgang;Woltering, Thomas J.;Wostl, Wolfgang;Pinard, Emmanuel;Mauser, Harald;Mayweg, Alexander V.;Rogers-Evans, Mark;Humm, Roland;Krummenacher, Daniela;Muser, Thorsten;Schnider, Christian;Jacobsen, Helmut;Ozmen, Laurence;Bergadano, Alessandra;Banner, David W.;Hochstrasser, Remo;Kuglstatter, Andreas;David-Pierson, Pascale;Fischer, Holger;Polara, Alessandra;Narquizian, Robert. And the article was included in Journal of Medicinal Chemistry in 2013.Reference of 38275-61-5 This article mentions the following:

An extensive fluorine scan of 1,3-oxazines revealed the power of fluorine(s) to lower the pKa and thereby dramatically change the pharmacol. profile of this class of BACE1 inhibitors. The CF3 substituted oxazine 89, a potent and highly brain penetrant BACE1 inhibitor, was able to reduce significantly CSF A灏?0 and 42 in rats at oral doses as low as 1 mg/kg. The effect was long lasting, showing a significant reduction of A灏?0 and 42 even after 24 h. In contrast to 89, compound 1b lacking the CF3 group was virtually inactive in vivo. In the experiment, the researchers used many compounds, for example, 5-Chloropyrimidine-2-carboxylic acid (cas: 38275-61-5Reference of 38275-61-5).

5-Chloropyrimidine-2-carboxylic acid (cas: 38275-61-5) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Reference of 38275-61-5

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Budesinsky, Zdenek et al. published their research in Collection of Czechoslovak Chemical Communications in 1972 | CAS: 38275-61-5

5-Chloropyrimidine-2-carboxylic acid (cas: 38275-61-5) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Application of 38275-61-5

Nucleophilic substitutions in the 2-methane sulfonylpyrimidine series was written by Budesinsky, Zdenek;Vavrina, Josef. And the article was included in Collection of Czechoslovak Chemical Communications in 1972.Application of 38275-61-5 This article mentions the following:

Oxidation of 5-substituted 2-methylthiopyrimidines gave the 2-methylsulfonyl derivatives, the nucleophilic substitution of which with NaOMe, N2H4, PhCH2NH2, NaCN, NaSH, and NaCH(CN)CO2Me gave the appropriate 5-substituted 2-methoxy-, 2-mercapto-, 2-hydrazino, 2-benzylamino-, 2-cyano-, and 2-(methoxycarbonylcyano-methyl)pyrimidine. 2-Methylsulfonyl-5-fluoropyrimidine (I) treated at 0° with NaOMe gave 2-methoxy-5-fluoropyrimidine but at a higher temperature and with excess NaOMe, 2,5-dimethoxypyrimidine was formed. I and N2H4 gave 5-hydrazino-2-meth-ylsulfonylpyrimidine. 5-Benzylamino-2-methylsulfonylpyri-midine was prepared analogously. At 10-20°, the reaction of 2 methylsulfonyl-5-halo(fluoro, chloro, bromo)pyrimidines with-NaCN gave the 2-cyano derivatives but at a higher temperature, 2-cyano-5-methylsulfonylpyrimidine was formed. 2-Cyano-5-methylpyrimidine, 2-cyano-5-methoxypyrimidine, 2-cyano-5-fluoropyrimidine, 2-cyano-5-chloropyrimidine, and 2-cyano-5-bromopyrimidine exhibited an intensive sweet taste. In the experiment, the researchers used many compounds, for example, 5-Chloropyrimidine-2-carboxylic acid (cas: 38275-61-5Application of 38275-61-5).

5-Chloropyrimidine-2-carboxylic acid (cas: 38275-61-5) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Application of 38275-61-5

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Simple exploration of 38275-61-5

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 38275-61-5, 5-Chloropyrimidine-2-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 38275-61-5 ,Some common heterocyclic compound, 38275-61-5, molecular formula is C5H3ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

5-Chloro-pyrimidine-2-carboxylic acid {4-[2-((S)-2-amino-4,5-dihydro-oxazol-4-yl)-ethyl]-phenyl}-amide The title compound was obtained in analogy to example S3 using 5-chloropyrimidine-2-carboxylic acid (CAS 38275-61-5) instead of 4-chlorobenzoic acid in step c). White solid. MS (ISP): 348.3 ([{37Cl}M+H]+), 346.1 ([{35Cl}M+H]+).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 38275-61-5, 5-Chloropyrimidine-2-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Hoener, Marius; Raab, Susanne; Risterucci, Celine; Sewing, Sabine; US2012/28964; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

New learning discoveries about 5-Chloropyrimidine-2-carboxylic acid

With the rapid development of chemical substances, we look forward to future research findings about 38275-61-5.

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 38275-61-5, name is 5-Chloropyrimidine-2-carboxylic acid, molecular formula is C5H3ClN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. HPLC of Formula: C5H3ClN2O2

Toa solution of 5-chloropyrimidine-2-carboxylic acid (0.16 g, 1.0 mmol) and (3S,3aS) -3- (aminomethyl) -7- (3-oxomorpholino) -3a, 4-dihydrobenzo [b] oxazolo[3, 4-d] [1, 4] oxazin-1 (3H) -one (0.32 g, 1.0 mmol) in N, N-dimethylformamide(10 mL) were added 1- (3-dimethylaminopropyl) -3-ethylcarbodiimidehydrochloride (0.38 g, 2.0 mmol) and 4-dimethylaminopyridine (0.31 g, 2.5 mmol). The mixture was reacted at rt for 10 hours. The reaction mixture wasconcentrated in vacuo to remove the solvent, and to the residue was addeddichloromethane (30 mL) . The resulting mixture was washed with aqueous sodiumhydroxide (10 mL, 2.0 mol/L) and water (10 mL) in turn, dried over anhydroussodium sulfate and filtered. The filtrate was concentrated in vacuo to remove thesolvent, and the crude product was purified by silica gel chromatography elutedwith DCM/MeOH (V/V) 30/1 to give the title compound as a white solid (0.167g, 36) . The compound was characterized by the following spectroscopic data:MS (ESI, pos. ion) m/z: 460.20 (M+1) and 1H NMR (400 MHz, d6-DMSO): delta 9.28 (t, J 6.0 Hz, 1H) , 9.10 (s, 2H) , 7.85 (d, J 8.7 Hz, 1H) , 7.05(d, J 2.2 Hz, 1H) , 7.01 (dd, J 8.7, 2.3 Hz, 1H) , 4.65 (dd, J 12.3, 5.6Hz, 1H) , 4.54 (dd, J 10.3, 3.0 Hz, 1H) , 4.17 (s, 2H) , 4.15 -4.01 (m, 2H) ,3.98 -3.92 (m, 2H) , 3.84 -3.74 (m, 2H) , 3.72 -3.65 (m, 2H) .

With the rapid development of chemical substances, we look forward to future research findings about 38275-61-5.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Jiancun; ZUO, Yinglin; ZHANG, Yingjun; WANG, Xiaojun; ZHANG, Jin; WEN, Liang; CHENG, Guanjun; WO2015/110024; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia