Category: 3921-01-5

Chukwu, Roxton; Hunter, Allen D.; Santarsiero, Bernard D. published the artcile< Organometallic complexes with electronic bridges. 6. Novel organometallic complexes containing aromatic azines: synthesis and x-ray crystal structure of 4,6-bis[(η5-cyclopentadienyl)dicarbonyliron] 2-(methylthio)pyrimidine>, Category: pyrimidines, the main research area is iron azine complex; pyridine iron complex; pyrazine iron complex; pyridazine iron complex; pyrimidine iron complex; crystal structure iron pyrimidine complex; mol structure iron pyrimidine complex; safety handling mercury.

The syntheses of 13 monometallic and 4 bimetallic complexes in which (η5-C5H5)Fe(CO)2 (Fp; C5H5 = cyclopentadienyl) groups are bound to substituted pyridine, pyrazine, pyridazine, and pyrimidine rings is described. These species are prepared by metathesis reactions between the appropriate number of equivalent of NaFp and the chloro- or fluoro-substituted azine precursors in 25-95% yields and structural factors affecting these yields are discussed. These new materials have been fully characterized by conventional spectroscopic techniques and are shown to contain Fe-C σ-bonds. The x-ray crystal structure of the title complex confirms that it has the expected structure about the pyrimidine ring. It also reveals that, contrary to expectations from frontier MO theory, the (η5-C5H5)Fe(CO)2 groups shows a preference for orientations in which its mirror plane is perpendicular to that of the pyrimidine ring. The spectroscopic data provide no evidence for the existence of any electronic interaction between the metal centers of the new bimetallic azine bridged complexes having meta substitution geometries.

Organometallics published new progress about Crystal structure. 3921-01-5 belongs to class pyrimidines, and the molecular formula is C4H2Br2N2, Category: pyrimidines.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adriaens, E. L.; Lozet, F. published the artcile< Fermented beverages of Ruanda natives>, Computed Properties of 3921-01-5, the main research area is .

The preparation of hydromel (I), and banana (II) and sorgho (III) beers is described. I contained before and after fermentation: dry extract 365.26-115.28, inorganic matter 10.78-6.20, total N 3.15-1.93, reducing sugars in glucose 250.0-66.11, sucrose 12.45-4.29, acidity as H2SO4 1.62-5.78 g./l.; in the wort: wax and sorgho yeast 86.9 g./l.; in the I EtOH 8.6°. Corresponding data for II were: 197.12-52.63, 11.14-9.87, trace-3.15, 93.74-19.16, 80.29-2.95, 3.28-4.21 g./l. and EtOH in the end product 9.46°. “”Inkanganza”” made from II with addition of honey and sorgho yeast gave, before and after fermentation: 149.2-52.88, 10.88-5.34, 5.08-3.75, 116.54-12.45, 11.91-4.33, 4.9-3.92 g./l., EtOH 11.5°. Wort of III and the end product contained: dry extract 172.9-256.8, inorganic 5.16-6.86, N 6.08-26.56, glucose 43.02-trace, sucrose 5.57-16.06, acids 2.11-5.98 g./l., EtOH 3.75°. Uryama, a III containing about 10% honey, gave: 244.83-136.24, 7.08-7.37, 10.68-3.15, 105.17-37.43, trace-0.0, 3.92-10.15 g./l., EtOH 6.4°.

Bull. Agr. Congo Belge published new progress about Beer. 3921-01-5 belongs to class pyrimidines, and the molecular formula is C4H2Br2N2, Computed Properties of 3921-01-5.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Sandosham, Jessie; Undheim, Kjell published the artcile< Stannylation in the electrophilic 2- and 4/6-pyrimidine position and the use of stannylpyrimidines in coupling and tin-lithium exchange reactions>, Quality Control of 3921-01-5, the main research area is stannylation electrophilic pyrimidine lithio; stannylpyrimidine coupling acyl chloride bromide; tin lithium exchange reaction stannylpyrimidine; carbonyl compound coupling stannylpyrimidine.

2-Stannylpyrimidines have been prepared by stannyl anion substitution in 2-chloropyrimidines. Stannylation in the 4-position was via the iodo-derivative or via the 4-lithio derivative and lithium-tin transmetalation. Tin-lithium exchange in the 2-position resulted in 2-lithiopyrimidine. Ketones were formed from the stannylpyrimidines and acid chlorides, aryl bromides required Pd-catalysis for coupling reaction.

Tetrahedron published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 3921-01-5 belongs to class pyrimidines, and the molecular formula is C4H2Br2N2, Quality Control of 3921-01-5.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Mosavian, Seyed Yousef; Ebrahimi-Kahrizsangi, Reza; Khah, Mohammad Malakooti; Hamidi, Zeinab; Rafiei, Amin; Behzadi, Mohsen published the artcile< Effect of Mechanical Activation on the Kinetics of Silica Carbothermal Reduction in non-Isothermal Conditions>, Application of C4H2Br2N2, the main research area is silica carbothermal reduction non isothermal condition mech activation kinetics.

The effect of mech. activation on the synthesis temperature decreasing of silicon carbide was investigated and a kinetic model of a carbothermic reduction of silicon carbide was obtained. Silicon carbide was synthesized using silica activated in a planetary mill at different times up to 40 h under an argon atm. Structural changes due to the milling and the reduction of the activated silica were studied by the X-Ray diffraction (XRD) method and non-isothermal TGA with a heating rate of 10oC min-1 resp. The kinetic model obtained by the fitting technique for an unmilled sample was found to be chem. controlled of the second order with E = 138.92 Kcal.mol-1 and A =3.92×1015 s-1. For the sample milled up to 20 h, according to the Avrami-Erofeev3 equation; A = 1465633 s-1 and E = 66.71 Kcal.mol-1.

Silicon published new progress about Activation energy. 3921-01-5 belongs to class pyrimidines, and the molecular formula is C4H2Br2N2, Application of C4H2Br2N2.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Zhang, Ning; Zheng, Caijun; Chen, Zhipeng; Zhao, Juewen; Zhang, Ming; Yang, Haoyu; He, Zeyu; Du, Xiaoyang; Tao, Silu published the artcile< Improving the efficiency of exciplex based OLEDs by controlling the different configurations of the donor>, Synthetic Route of 3921-01-5, the main research area is organic light emitting diode efficiency donor configuration.

Two D-A-D type donor materials, 10,10′-(pyridine-2,4-diyl)bis(9,9-dimethyl-9,10-dihydroacridine) (Pra-2DMAC) with vertical mol. conformation and 10,10′-(pyrimidine-2,4-diyl)bis(9,9-dimethyl-9,10-dihydroacridine) (Prm-2DMAC) with near-planar mol. conformation, were designed and synthesized in order to develop the performance of exciplex based OLEDs. Pra-2DMAC shows a better performance than Prm-2DMAC, due to its vertical configuration, which has a beneficial effect on exciplex emission because the separated HOMO and LUMO in donor facilitates the intramol. charge transfer (ICT) and reverse intersystem crossing (RISC) process at the excited state. An exciplex device with a simple structure based on Pra-2DMAC shows a high maximum external quantum efficiency (EQE) of 15.0% (13.9% at 1000 cd m-2), low turn-on voltage of 2.4 V, and stable electroluminescence spectrum of nearly constant CIE coordinate. The better performance of Pra-2DMAC demonstrates the superiority of the donor with vertical configurations in an exciplex system. To our knowledge, this is the first work to study exciplex based OLEDs using dual configuration donor materials.

Journal of Materials Chemistry C: Materials for Optical and Electronic Devices published new progress about Cyclic voltammetry. 3921-01-5 belongs to class pyrimidines, and the molecular formula is C4H2Br2N2, Synthetic Route of 3921-01-5.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Woodring, Jennifer L.; Bachovchin, Kelly A.; Brady, Kimberly G.; Gallerstein, Mitchell F.; Erath, Jessey; Tanghe, Scott; Leed, Susan E.; Rodriguez, Ana; Mensa-Wilmot, Kojo; Sciotti, Richard J.; Pollastri, Michael P. published the artcile< Corrigendum to ""Optimization of physicochemical properties for 4-Anilinoquinazoline inhibitors of trypanosome proliferation"" [Eur. J. Med. Chem. 141 (2017) 446-459] [Erratum to document cited in CA167:595582]>, Recommanded Product: 2,4-Dibromopyrimidine, the main research area is anilinoquinazoline trypanosome inhibitor antimalarial malaria trypanosomiasis trypanosomicide erratum.

In the original publication, the acknowledgments section has information omitted; the correction is provided here.

European Journal of Medicinal Chemistry published new progress about Antimalarials. 3921-01-5 belongs to class pyrimidines, and the molecular formula is C4H2Br2N2, Recommanded Product: 2,4-Dibromopyrimidine.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Woodring, Jennifer L.; Bachovchin, Kelly A.; Brady, Kimberly G.; Gallerstein, Mitchell F.; Erath, Jessey; Tanghe, Scott; Leed, Susan E.; Rodriguez, Ana; Mensa-Wilmot, Kojo; Sciotti, Richard J.; Pollastri, Michael P. published the artcile< Optimization of physicochemical properties for 4-anilinoquinazoline inhibitors of trypanosome proliferation>, Product Details of C4H2Br2N2, the main research area is anilinoquinazoline trypanosome inhibitor antimalarial malaria trypanosomiasis trypanosomicide; Human African trypanosomiasis; Leishmania major; Neglected tropical disease; Plasmodium falciparum; Target class repurposing; Trypanosoma brucei; Trypanosoma cruzi.

Human African trypanosomiasis (HAT) is a deadly disease in need of new chemotherapeutics that can cross into the central nervous system. The authors previously reported the discovery of (NEU-617), a small mol. with activity against T. brucei bloodstream proliferation. Further optimization of NEU-617 to improve the physicochem. properties (LogP, LLE, [1], and MPO score) [2] have led us to twelve sub-micromolar compounds, most importantly the headgroup variants I and II, and the linker variant III. Although these 3 compounds had reduced potency compared to NEU-617, they all had improved LogP, LLE and MPO scores. Cross-screening these analogs against other protozoan parasites uncovered IV with potent activity towards T. brucei, T. cruzi and L. major, while four others compounds showed activity towards P. falciparum D6. This reinforces the effectiveness of lead repurposing for the discovery of new protozoan disease therapeutics.

European Journal of Medicinal Chemistry published new progress about Antimalarials. 3921-01-5 belongs to class pyrimidines, and the molecular formula is C4H2Br2N2, Product Details of C4H2Br2N2.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Jung, Seung-Youn; Nam, Ky-Youb; Park, Jeong-In; Song, Kyung-Hee; Ahn, Jiyeon; Park, Jong Kuk; Um, Hong-Duck; Hwang, Sang-Gu; Choi, Sang Un; Song, Jie-Young published the artcile< Radiosensitizing effect of novel phenylpyrimidine derivatives on human lung cancer cells via cell cycle perturbation>, Product Details of C4H2Br2N2, the main research area is lung cancer cell phenylpyrimidine derivative radiosensitizing.

Radiotherapy is one of the most common treatments for cancer, but radioresistance and injury to normal tissue are considered major obstacles to successful radiotherapy. Thus, there is an urgent need to develop radiosensitizers to improve the therapeutic outcomes of radiotherapy in cancer patients. Our previous efforts to identify novel radiosensitizers, using high-throughput screening targeting p53 and Nrf2 revealed a promising N-phenylpyrimidin-2-amine (PPA) lead compound; 17 derivatives of this lead compound were examined in the present study. PPA5, 13, 14, 15, and 17 inhibited cell viability by more than 50% with a marked increase in the proportion of cells arrested at the G2/M phase of cell cycle. Among these compounds, PPA15 markedly increased the sub-G1 cell population and increased the levels of cyclin B1 and phosphorylation levels of cyclin-dependent kinases 1 (CDK1). Combined treatment with radiation and PPA14 or PPA15 significantly decreased clonogenic survival. An in vitro kinase assay revealed that PPA15 inhibited multiple CDKs involved in cell cycle regulation. Compared with drug or radiation treatment alone, combined treatment with PPA15 and radiation resulted in the suppression of A549 tumor growth in mice by 59.5% and 52.7%, resp. Treatment with PPA15 alone directly inhibited tumor growth by 25.7%. These findings suggest that the novel pan CDK inhibitor, PPA15, may be a promising treatment to improve the effectiveness of radiotherapy for the treatment of cancer.

Journal of Pharmacology and Experimental Therapeutics published new progress about Apoptosis. 3921-01-5 belongs to class pyrimidines, and the molecular formula is C4H2Br2N2, Product Details of C4H2Br2N2.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Mosrin, Marc; Knochel, Paul published the artcile< Regio- and Chemoselective Multiple Functionalization of Pyrimidine Derivatives by Selective Magnesiations using TMPMgCl·LiCl>, Product Details of C4H2Br2N2, the main research area is chlorotetramethylpiperidinylmagnesium lithium chloride magnesiation pyrimidine reaction electrophile.

Successive regio- and chemoselective magnesiations of pyrimidines using TMPMgCl·LiCl furnish, after trapping with various electrophiles, highly functionalized derivatives, e.g. I, in good to excellent yields. Applications to the synthesis of antiviral and anti-inflammatory agents such as p38 and sPLA2 kinase inhibitors are reported.

Organic Letters published new progress about Chemoselectivity. 3921-01-5 belongs to class pyrimidines, and the molecular formula is C4H2Br2N2, Product Details of C4H2Br2N2.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Dolsak, Ana; Mrgole, Kristjan; Sova, Matej published the artcile< Microwave-assisted regioselective suzuki coupling of 2,4-dichloropyrimidines with aryl and heteroaryl boronic acids>, Application of C4H2Br2N2, the main research area is dihalopyrimidine boronic acid palladium regioselective Suzuki coupling microwave irradiation; halo arylpyrimidine preparation.

The Suzuki coupling of 2,4-dihalopyrimidines with aryl and heteroaryl boronic acids was investigated. A thorough screening of reaction conditions and the use of microwave irradiation leded to a very efficient and straightforward synthetic procedure provided arylpyrimidines in good to excellent yields. Short reaction time (15 min) and extremely low catalyst loading (0.5 mol%) were the main advantages of our tetrakis(triphenylphosphine)palladium(0) catalyzed microwave-assisted procedure, which could be used for quick and low-cost regioselective preparation of pyrimidine rings.

Catalysts published new progress about Arylboronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 3921-01-5 belongs to class pyrimidines, and the molecular formula is C4H2Br2N2, Application of C4H2Br2N2.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia