3921-01-5 | Page 2 of 2

Gronowitz, S’s team published research in Chemica Scripta in 1986-06-30 | 3921-01-5

Chemica Scripta published new progress about Coupling reaction. 3921-01-5 belongs to class pyrimidines, and the molecular formula is C4H2Br2N2, Computed Properties of 3921-01-5.

Gronowitz, S.; Hoernfeldt, A. B.; Kristjansson, V.; Musil, T. published the artcile< On the synthesis of various thienyl- and selenienylpyrimidines>, Computed Properties of 3921-01-5, the main research area is halopyrimidine coupling thiopheneboronic acid; selenopheneboronic acid coupling halopyrimdine; pyrimidineboronic acid coupling bromothiophene; bromoselenophene coupling pyrimidineboronic acid; palladium coupling catalyst halopyrimidine; thienylpyrimidine; selenienylpyrimidine.

Various thienyl- and selenienylpyrimidines, including 5-substituted uracils, were prepared by the Pd(0)-catalyzed coupling between halopyrimidines I (R = H, Cl, Br, Me3CO, PhCH2O; R1 = Br, H) and thiopheneboronic acids and selenopheneboronic acids II [R2 = B(OH)2; X = S, Se, resp.]. 5-Bromouracil had to be protected as the tert-butoxy or benzyloxy derivative in order to achieve successful coupling. The compounds could also be obtained in a reversed manner, when pyrimidineboronic acids I [R = H, Me3CO; R1 = B(OH)2] were coupled with halothiophenes and haloselenophenes II (R2 = Br; X = S, Se).

Chemica Scripta published new progress about Coupling reaction. 3921-01-5 belongs to class pyrimidines, and the molecular formula is C4H2Br2N2, Computed Properties of 3921-01-5.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Schweizer, Stefan A’s team published research in Synlett in 2010-01-04 | 3921-01-5

Synlett published new progress about Haloalkyl silanes, fluoroalkyl Role: RCT (Reactant), RACT (Reactant or Reagent). 3921-01-5 belongs to class pyrimidines, and the molecular formula is C4H2Br2N2, Product Details of C4H2Br2N2.

Schweizer, Stefan A.; Bach, Thorsten published the artcile< Regioselective Pd(0)-catalyzed Hiyama cross-coupling reactions at dihalo-substituted heterocycles>, Product Details of C4H2Br2N2, the main research area is haloheterocycle regioselective Hiyama cross coupling alkyl fluorosilane palladium catalyst.

The regioselectivity of the Hiyama cross-coupling reaction at various dihalo-substituted heterocycles was studied. Me 2,3-dibromo-5-furancarboxylate and n-octyltrifluorosilane were employed to find optimum reaction conditions [CsF; Pd2dba3/P(2-furyl)3 as catalyst, 80-150 °C in toluene or benzene] for the desired transformation. Subsequent experiments with the title compounds and with different primary alkyltrifluorosilanes illustrate the generality of this regiochem. process.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

27-Sep News A new synthetic route of 3921-01-5

With the rapid development of chemical substances, we look forward to future research findings about 3921-01-5.

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3921-01-5, name is 2,4-Dibromopyrimidine, molecular formula is C4H2Br2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of 2,4-Dibromopyrimidine

2,4-dibromopyrimidine (438.4mg, 1.84mmol) and potassium carbonate (1.27g, 9.21mmol) in tetrahydrofuran (10mL) were added together and stirred at room temperature for 5min. Morpholine (174.8muL, 2.03mmol) was then added dropwise and the solution continued to stir at room temperature for 5h. The reaction mixture was filtered and the filtrate was collected and then concentrated under reduced pressure. The products were purified by silica column chromatography in hexanes and ethyl acetate to afford 28a and 28b in 19% and 66% yields, respectively. (0070) 4-(4-bromopyrimidin-2-yl)morpholine (28a). (White solid, Yield: 19%). 1H NMR (500MHz, CDCl3) delta ppm 3.74-3.77 (m, 4H) 3.79-3.83 (m, 4H) 6.70 (d, J=4.88Hz, 1H) 8.05 (d, J=4.88Hz, 1H). LCMS found 246.0, [M+H]+. (0071) 4-(2-bromopyrimidin-4-yl)morpholine (28b). (White solid, Yield: 66%) 1H NMR (500MHz, CDCl3) delta ppm 3.66 (br. s., 4H) 3.76-3.83 (m, 4H) 6.43 (d, J=6.35Hz, 1H) 8.02 (d, J=6.35Hz, 1H). LCMS found 246.0, [M+H]+.

With the rapid development of chemical substances, we look forward to future research findings about 3921-01-5.

Reference:
Article; Woodring, Jennifer L.; Bachovchin, Kelly A.; Brady, Kimberly G.; Gallerstein, Mitchell F.; Erath, Jessey; Tanghe, Scott; Leed, Susan E.; Rodriguez, Ana; Mensa-Wilmot, Kojo; Sciotti, Richard J.; Pollastri, Michael P.; European Journal of Medicinal Chemistry; vol. 141; (2017); p. 446 – 459;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Sources of common compounds: 3921-01-5

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 3921-01-5, 2,4-Dibromopyrimidine.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3921-01-5, name is 2,4-Dibromopyrimidine. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C4H2Br2N2

[0484] Step 1: Synthesis of 2-bromo-4-(2-(tert-butyl)pyridin-4-yl)pyrimidine. In a glass tube, 2,4-dibromopyrimidine (400 mg, 1.68 mmol) was dissolved in l,4-dioxane/H20 (9:1,10 mL), and (2′-(tert-butyl)pyridin-4-yl)boronic acid (2′-200 mesh), eluted with 10% EA in hexanes. Removal of the solvent under reduced pressure gave 2-bromo-4-(2′-(tert-butyl)pyridin- 4-yl)pyrimidine as a gummy liquid (250mg, 51%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 3921-01-5, 2,4-Dibromopyrimidine.

Reference:
Patent; CAPULUS THERAPEUTICS, LLC; GREEN, Michael John; HART, Barry Patrick; (341 pag.)WO2019/148125; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Some tips on 2,4-Dibromopyrimidine

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3921-01-5, 2,4-Dibromopyrimidine.

Reference of 3921-01-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3921-01-5, name is 2,4-Dibromopyrimidine, molecular formula is C4H2Br2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Starting material2,4-dibromopyrimidine (CAS Registry Number: 3921-01-5) (24.46 g, 102.82 mmol)Was dissolved in THF (360ml) in a round bottom flask, 4,4,5,5-tetramethyl-2- (naphthalen-1-yl-ethyl) -1,3,2-dioxaborolane (CAS Registry Number: 1280709-91-2) (29.54 g, 113.11 mmol),Pd (PPh3) 4 (4.75 g, 4.11 mmol),K2CO3 (42.63 g, 308.47 mmol),Water (180 ml)And the mixture was stirred at 90 C.After the reaction was completed, the reaction mixture was extracted with CH 2 Cl 2 and water. The organic layer was dried over MgSO 4 and concentrated. The resulting compound was purified by silicagel column and recrystallized to obtain 18.03 g (yield: 60%) of the product.

Reference:
Patent; Duksan Neolux Co.,Ltd.; Park Mu-jin; Choi Yeon-hui; Moon Seong-yun; Jeong Ho-yeong; Song Hyeon-ju; Lee Mun-jae; Kwon Jae-taek; (46 pag.)KR2017/103105; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Simple exploration of 2,4-Dibromopyrimidine

The synthetic route of 3921-01-5 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3921-01-5, name is 2,4-Dibromopyrimidine, the common compound, a new synthetic route is introduced below. Safety of 2,4-Dibromopyrimidine

The synthetic route of 3921-01-5 has been constantly updated, and we look forward to future research findings.