Category: 392326-81-7

Reference of 392326-81-7 ,Some common heterocyclic compound, 392326-81-7, molecular formula is C10H8BrN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Compound 8a (12.5 g, 50.0 mmol), 2-bromo-2-phenylacetophenone (16.5 g, 60.0 mmol), NaHCO3(5.04g, 60.0mmol) were dissolved in isopropanol (100 mL), refluxed and Stir for 12h.The isopropanol was removed by rotary evaporation in vacuo, and then dichloromethane (60 mL) and water (30 mL) were added to the solid residue.After the organic phase was separated, it was washed twice with saturated saline.The solvent was removed by vacuum rotary evaporation, and the residue was purified by silica gel chromatography to obtain solid compound 8b (13.2 g, 31.0 mmol) in a yield of 62%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 392326-81-7, 4-(4-Bromophenyl)pyrimidin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shenzhen Huaxing Optoelectric Semiconductor Display Co., Ltd.; Wang Shipan; (37 pag.)CN110357882; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 392326-81-7, Adding some certain compound to certain chemical reactions, such as: 392326-81-7, name is 4-(4-Bromophenyl)pyrimidin-2-amine,molecular formula is C10H8BrN3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 392326-81-7.

To a slurry of 4-(4-bromo-phenyl)-pyrimidin-2-ylamine (300 mg, 1 mmol), bis(pinacolato)diborane (400 mg, 1.6 mmol), KOAc (330 mg, 3.3 mmol) in dioxane (7 mL) was added Pd(dppf)Cl2 (60 mg). The reaction mixture was heated to 100 C. for 2 h then cooled to RT. The solvent was removed. The residue was dissolved in DCM, washed with H2O, and dried (Na2SO4). Upon concentration, some of the product precipitated out and was collected to afford 90 mg of a mixture of 4-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-pyrimidin-2-ylamine (70) and the corresponding boronic acid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 392326-81-7, 4-(4-Bromophenyl)pyrimidin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Roche Palo Alto LLC; US2011/70190; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia