39551-54-7 | Pyrimidines

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If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 39551-54-7, 2,4-Dichloropyrido[3,2-d]pyrimidine.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 39551-54-7, name is 2,4-Dichloropyrido[3,2-d]pyrimidine. A new synthetic method of this compound is introduced below., Application In Synthesis of 2,4-Dichloropyrido[3,2-d]pyrimidine

To a solution of 116E (50 mg, 0.22 mmol) and 2,4-dichloropyrido[3,2-d]pyrimidine (45 mg, 0.22 mmol) in THF (3 mL) was added N,N-diisopropylethylamine (0.12 mL, 0.67 mmol). After stirring at 80 C. for 18 h, the reaction was cooled to ambient temperature, diluted with EtOAc (25 mL), washed with water (25 mL) and brine (25 mL), dried over Na2SO4, and concentrated in vacuo. The residue was subjected to silica gel chromatography eluting with hexanes-EtOAc (0-100%) to provide 116F. LCMS (m/z): 350.06 [M+H]+; tR=1.09 min. on LC/MS Method A

Reference:
Patent; Gilead Sciences, Inc.; Aktoudianakis, Evangelos; Chin, Gregory; Mackman, Richard L.; Metobo, Samuel E.; Mish, Michael R.; Pyun, Hyung-jung; Zablocki, Jeff; (175 pag.)US2016/289229; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

10/9/2021 News Some scientific research about 39551-54-7

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 39551-54-7, name is 2,4-Dichloropyrido[3,2-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 39551-54-7

To a solution of 6h (200 mg, 0.30 mmol) and 2,4- dichloropyrido[3,2-cf|pyrimidine (59.6 mg, 0.30 mmol) in THF (3 mL) was added NN- diisopropylethylamine (0.21 mL, 1.19 mmol). After stirring at 75C for 18 h, the reaction was cooled to rt, diluted with EtOAc (10 mL), washed with water (10 mL) and brine (10 mL), dried over Na2SC>4, then filtered and concentrated in vacuo. The residue was subjected to silica gel chromatography eluting with hexanes-EtOAc to provide 6i. LC/MS (ESI) calculated for C15H20CIN5O: m/z 322.14, found 322.12 [M+H]+; tR = 0.98 min. on LC/MS Method A.

Reference:
Patent; GILEAD SCIENCES, INC.; CHIN, Gregory; MACKMAN, Richard L.; MISH, Michael R.; ZABLOCKI, Jeff; (121 pag.)WO2018/45150; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

New downstream synthetic route of 2,4-Dichloropyrido[3,2-d]pyrimidine

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Electric Literature of 39551-54-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 39551-54-7, name is 2,4-Dichloropyrido[3,2-d]pyrimidine, molecular formula is C7H3Cl2N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

2,4,-dichloropyrido[3,2-d]pyrimidine (80 mg, 0.39 mmol, 1 equiv.) was treated with THF (10 ml) followed by N,N-diisopropylethylamine (0.28 mL, 1.5 mmol, 4 equiv.), and then (R)-methyl 2-amino-5,5-difluorohexanoate 79C (110 mg, 0.39 mmol, 1 equiv., TFA salt). The reaction mixture was stirred for 1 h to form 79D and then this solution was used directly. LCMS (m/z): 345.11 [M+H]+; tR=1.09 min. on LC/MS Method A.

Some scientific research about 2,4-Dichloropyrido[3,2-d]pyrimidine

Statistics shows that 39551-54-7 is playing an increasingly important role. we look forward to future research findings about 2,4-Dichloropyrido[3,2-d]pyrimidine.

Electric Literature of 39551-54-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.39551-54-7, name is 2,4-Dichloropyrido[3,2-d]pyrimidine, molecular formula is C7H3Cl2N3, molecular weight is 200.0248, as common compound, the synthetic route is as follows.

A mixture of [2-(trifluoromethyl)-3-pyridyl]methanamine (132 mg, 750 umol, 1.00 eq), 2,4-dichloropyrido[3,2-d]pyrimidine (150 mg, 750 umol, 1.00 eq) and Et3 (152 mg, 1.50 mmo, 2.00 eq) in THF (10.00 mL) was stirred at 10-20C for 12 hours. LC S showed ail of 2,4-dichloropyrido[3,2-d]pyrimidine was consumed and a new peak with desired MS. The mixture was concentrated to give a residue. The residue was triturated with EtOAc (2 mL). 2-chloro-N-[[2-(trifluoromethyl)-3-pyridyl]methyl]pyrido[3,2-d]pyrimidin-4-amine (120 mg, 77 umol, 23% yield, 50% purity) was obtained as an off-white solid.

Statistics shows that 39551-54-7 is playing an increasingly important role. we look forward to future research findings about 2,4-Dichloropyrido[3,2-d]pyrimidine.

Reference:
Patent; LIVERPOOL SCHOOL OF TROPICAL MEDICINE; THE UNIVERSITY OF LIVERPOOL; EISAI R&D MANAGEMENT CO., LTD.; WARD, Stephen A.; TAYLOR, Mark J.; O’NEILL, Paul M.; HONG, Weiqian David; BENAYOUD, Farid; (300 pag.)WO2018/134685; (2018); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 2,4-Dichloropyrido[3,2-d]pyrimidine

With the rapid development of chemical substances, we look forward to future research findings about 39551-54-7.

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 39551-54-7, name is 2,4-Dichloropyrido[3,2-d]pyrimidine, molecular formula is C7H3Cl2N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C7H3Cl2N3

A mixture of 2,4-dichloropyrido[3,2-d]pyrimidine (150 mg, 749.91 mupiiotaomicron, 1 eq), 4,5,6,7- tetrahydro-lH-indol-5-amine (113.48 mg, 749.91 muiotaetaomicron, 1 eq) and DIEA (387.68 mg, 3.00 mmol, 522.48 mu., 4 eq) in z-PrOH (10 mL) was stirred at 55 C for 2 h. The reaction mixture was concentrated to yield the residue which was purified on silica gel column chromatography (from PE/EtOAc = 3/1 to 1/1, TLC: PE/EtOAc = 1/1, Rf = 0.50) to yield 2-chloro-N-(4,5,6,7-tetrahydro- lH-indol-5-yl)pyrido[3,2-d]pyrimidin-4-amine (120 mg, 397.52 muiotaetaomicron, 53.0% yield, 99.3% purity) as a yellow solid. 1H MR (400 MHz, CDCb) S ppm 8.64 (dd, J= 1.5, 4.3 Hz, 1H), 8.01 (dd, J = 1.5, 8.5 Hz, 1H), 7.85 (s, 1H), 7.64 (dd, J= 4.3, 8.3 Hz, 1H), 7.44 (d, J= 8.5 Hz, 1H), 6.70 (t, J = 2.6 Hz, 1H), 6.04 (t, J= 2.6 Hz, 1H), 4.80-4.70 (m, 1H), 3.10 (dd, J= 5.3, 15.3 Hz, 1H), 2.99-2.45 (m, 3H), 2.24-2.08 (m, 2H); ES-LCMS m/z 300.1 [M+H]+.

With the rapid development of chemical substances, we look forward to future research findings about 39551-54-7.

Reference:
Patent; KYN THERAPEUTICS; CASTRO, Alfredo C.; EVANS, Catherine Anne; (632 pag.)WO2018/195397; (2018); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Analyzing the synthesis route of 2,4-Dichloropyrido[3,2-d]pyrimidine

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,39551-54-7, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 39551-54-7, 2,4-Dichloropyrido[3,2-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 39551-54-7, blongs to pyrimidines compound. Recommanded Product: 39551-54-7

To a solution of 2,4-dichloropyrido[3,2-d]pyrimidine (CAS39551-54-7, supplied by Astatech, Inc.) (50 mg, 0.25 mmol) in THF (2 mL) was added butan-1-amine (0.03 mL, 0.28 mmol) and N,N-diisopropylethylamine (0.13 ml, 0.75 mmol). After stirring at room temperature for 30 minutes, 2,4-dimethoxybenzylamine (0.19 ml, 1.25 mmol) and N,N-diisopropylethylamine (0.13 ml, 0.75 mmol) were added and the mixture was heated to 100 C. After 16 hours, the reaction was cooled to room temperature, diluted with ethyl acetate, washed with water and brine, dried over Na2SO4, and concentrated in vacuo. The product ( 1A) was obtained after flash chromatography. MS (m/z): 368.14 [M+H]+

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,39551-54-7, its application will become more common.

Analyzing the synthesis route of 39551-54-7

Compound 94j (195.7 mg, 0.798 mmol) was dissolved in 4M HCl in dioxane (3 mL) and stirred at rt for 1 h. The reaction mixture was then concentrated in vacuo. The residue was treated with 2-methyltetrahydrofuran (5 mL), 2,4-dichloropyrido[3,2-d]pyrimidine (160 mg, 0.525 mmol) and N,N-diisopropylethylamine (0.57 mL, 3.272 mmol) and heated with an 80 C. bath for 3 h. The reaction mixture was cooled to rt, concentrated under reduced pressure and the residue was subjected to silica gel chromatography eluting with 0-100% EtOAc in hexanes to obtain compound 96a as a mixture of two diastereomers (2:3 ratio). LCMS-ESI+ (m/z): [M+H]+ calculated for C15H22ClN4O: 309.15. found: 309.08; TR=1.41 min on LC/MS Method A.

Analyzing the synthesis route of 39551-54-7

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,39551-54-7, its application will become more common.

2,4,-dichloropyrido[3,2-d]pyrimidine (163 mg, 0.82 mmol, 1.1 equiv.) was dissolved in dioxane (6 mL), N,N-diisopropylethylamine (0.53 mL, 2.9 mmol, 4 equiv.) and (R)-methyl 2-amino-6-fluorohexanoate 74C (205 mg, 0.74 mmol, 1 equiv.). The reaction mixture was stirred for 1 h and then the mixture of 74D used directly. LCMS (m/z): 326.80 [M+H]+; tR=1.04 min. on LC/MS Method A.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,39551-54-7, its application will become more common.

New downstream synthetic route of 2,4-Dichloropyrido[3,2-d]pyrimidine

At the same time, in my other blogs, there are other synthetic methods of this type of compound,39551-54-7, 2,4-Dichloropyrido[3,2-d]pyrimidine, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.39551-54-7, name is 2,4-Dichloropyrido[3,2-d]pyrimidine, molecular formula is C7H3Cl2N3, molecular weight is 200.0248, as common compound, the synthetic route is as follows.Application In Synthesis of 2,4-Dichloropyrido[3,2-d]pyrimidine

2,4,-dichloropyrido[3,2-d]pyrimidine (33 mg, 0.16 mmol, 1.25 equiv.) was treated with THF (10 mL) followed by N,N-diisopropylethylamine (0.18 mL, 1.0 mmol, 8 equiv.), and (R)-methyl 2-amino-5,5-difluorohexanoate 78C (36 mg, 0.13 mmol, 1 equiv., TFA salt). The reaction mixture was stirred for 1 h to generate 78D and then this mixture was used directly. LCMS (m/z): 345.13 [M+H]+; tR=1.08 min. on LC/MS Method A.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,39551-54-7, 2,4-Dichloropyrido[3,2-d]pyrimidine, and friends who are interested can also refer to it.

Share a compound : 2,4-Dichloropyrido[3,2-d]pyrimidine

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,39551-54-7, its application will become more common.

To a solution of compound 88d (14.9 mg, 0.100 mmol) and 2,4-dichloropyrido[3,2-d]pyrimidine (11.6 mg, 0.158 mmol) in THF (2 mL) was added N,N-diisopropylethylamine (0.1 mL, 0.574 mmol). The mixture was stirred at rt for 1.5 h and at 50 C. for 30 min. The reaction mixture was then concentrated in vacuo, and the residue subjected to silica gel chromatography eluting with 20-70% EtOAc in hexanes to obtain compound 88e. LCMS-ESI+ (m/z): [M+H]+ calculated for C14H19ClFN4O: 313.12. found: 313.14; tR=1.06 min on LC/MS Method A.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,39551-54-7, its application will become more common.