Category: 3977-29-5

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3977-29-5, name is 2-Amino-6-methylpyrimidin-4(1H)-one, molecular formula is C5H7N3O, molecular weight is 125.13, as common compound, the synthetic route is as follows.Product Details of 3977-29-5

1,12-Diisocyanatododecane (4.5 g) and methylisocytosine (or 2-amino-4-hydroxy-6-methyl-pyrimidine, 0.37 g) were suspended in a 10 mL flask. The mixture was stirred overnight at 90° C. under an argon atmosphere. After cooling to room temperature, 2 mL of hexane was added to the suspension, while stirring was continued. The suspension was poured into 40 mL of hexane. The precipitated product was filtered, washed with several portions of hexane and dried in vacuum. A white powder was obtained. 1H NMR (300 MHz, CDCl3): delta 13.1 (1H), 11.8 (1H), 10.1 (1H), 5.8 (1H), 3.3 (4H), 2.1 (3H), 1.6 (4H), 1.4 (16H). FT-IR (neat): nu (cm-1) 2918, 2267, 1698, 1665, 1577, 1523, 1223.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3977-29-5, 2-Amino-6-methylpyrimidin-4(1H)-one, and friends who are interested can also refer to it.

Reference:
Patent; SupraPolix B.V.; US2008/260795; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3977-29-5, name is 2-Amino-6-methylpyrimidin-4(1H)-one, molecular formula is C5H7N3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. COA of Formula: C5H7N3O

Methyl isocytosine (2.0 g) was added to 4,4′-methylenebis (phenylisocyanate) (MDI, 8.1 g) dissolved in 35 mL THF and subsequently stirred at an oil bath temperature of 75 [C] under an argon atmosphere. After 4 hours, 40 [ML] chloroform was added and the white precipitate was separated by filtration and washed with chloroform. 1H NMR (400 MHz, DMSO-d6): 8 10.0 (1H), 8.6 (1H), 7.4 [(5H),] 7.2 (4H), 5.8 (1H), 3.8 (2H), 2.1 (3H). FT-IR (neat): v [(CRI-1)] 3329,2954, 2257,1699, 1658,1578, [1508,] 1244.

With the rapid development of chemical substances, we look forward to future research findings about 3977-29-5.

Reference:
Patent; SUPRAPOLIX, B.V.; WO2004/16598; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 3977-29-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3977-29-5, name is 2-Amino-6-methylpyrimidin-4(1H)-one. A new synthetic method of this compound is introduced below.

In a two-neck round-bottom flask containing precooled sulfuricacid (3 mL) was added 2-amino-4-hydroxy-6-methylpyrimidine(1) (100 mg, 0.8 mmol). An effective temperature control isrequired to the nitration occur properly. Nitric acid (0.2 mL,3.0 mmol) was added to the solution dropwise maintaining thetemperature below 6 C using an ice bath. The mixture waswarmed to room temperature and stirred for 3 h. The reaction mixturewas added in cold ethyl ether (10 mL), remaining the temperaturebelow 10 C. The precipitate was filtered and dissolved inboiling 1 mol/L NaOH solution. Acetic acid was added to the solutionfor precipitation of the product (pH among 6-8). The solid wasfiltered under vacuum, washed with water (2 1 mL) and dried invacuum for 8 h. The pyrimidinone 2 was obtained in 69% yield(117 mg)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3977-29-5, its application will become more common.

Reference:
Article; Rodrigues, Marili V.N.; Barbosa, Alexandre F.; Da Silva, Julia F.; Dos Santos, Deborah A.; Vanzolini, Kenia L.; De Moraes, Marcela C.; Correa, Arlene G.; Cass, Quezia B.; Bioorganic and Medicinal Chemistry; vol. 24; 2; (2016); p. 226 – 231;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3977-29-5, name is 2-Amino-6-methylpyrimidin-4(1H)-one, molecular formula is C5H7N3O, molecular weight is 125.13, as common compound, the synthetic route is as follows.Quality Control of 2-Amino-6-methylpyrimidin-4(1H)-one

A. 2-Amino-4-methyl-6-benzyloxypyrimidine 2-Amino-4-methyl-6-hydroxypyrimidine (62.5 g., 0.50 mole) is dissolved in 500 ml of dimethylformamide and sodium hydride (0.5 mole) is added over a 1 hour period under a nitrogen atmosphere. The mixture is heated at 75¡ã C. for 11/2 hours. Benzyl chloride (69.3 g., 0.55 moles) is then added over 15 minutes and the mixture is heated at 90¡ã C. and stirred for 11/2 hours. After cooling, the reaction mixture is filtered and concentrated under vacuum to an oil from which 2-amino-4-methyl-6-benzyloxypyrimidine melting at 108¡ã-109.5¡ã C. is obtained by crystallization from n-butyl chloride.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3977-29-5, 2-Amino-6-methylpyrimidin-4(1H)-one, and friends who are interested can also refer to it.

Reference:
Patent; Merck & Co., Inc.; US4144338; (1979); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia