Related Products of 39786-40-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.39786-40-8, name is 4-Chloro-2-methylbenzofuro[3,2-d]pyrimidine, molecular formula is C11H7ClN2O, molecular weight is 218.6391, as common compound, the synthetic route is as follows.
A solution of 4-chloro-2-methyl-benzofuro[3,2-djpyrimidine (70.0 mg, 0.32 mmol), DIEA (85 jiL, 0.50 mmol) and n-butylamine (100 jiL, 1.01 mmol) in 1,4-dioxane (2.0 mL) was heated at 140 C in a microwave reactor for 3 h to give a pale yellow suspension. The crude residue was purified by reversephase preparative HPLC. The purified residue was dissolved in acetonitrile containing a trace of methanol and the solution was passed through a SiliaPrep Carbonate (Si-C03) 6 mL-1 g cartridge. Thefiltrate was evaporated in vacuo to afford a colorless crystalline solid (79.6 mg, yield 97%). LC-MS analysis of the freebase residue showed the desired product with a purity >98% and the desired product?smass: m/z 256 (M+H); Calcd for C15H17N30 = 255.32. 1H NMR (400 MHz, CDC13): oe 1.01 (t, J= 7.34Hz, 3H, CH3-CH2-CH2-), 1.50 (sxt, J= 7.38 Hz, 2H, -CH2-CH2-CH2-), 1.71 (quin, J 7.34 Hz, 2H, -CH2-CH2-CH2-), 2.70 (s, 3H, 2-CH3-), 3.72 (q, J 6.77 Hz, 2H, -CH2-CH2-CH2-), 5.14 (brs/appt, 1H, -NH-), 7.41 (dt, J = 7.95 and 4.10 Hz, 1H, Ph-), 7.57 (d, J = 4.16 Hz, 2H, Ph-), 8.16 (d, J 7.82 Hz, 1H,Ph-).
The chemical industry reduces the impact on the environment during synthesis 39786-40-8, I believe this compound will play a more active role in future production and life.
Reference:
Patent; SAINT LOUIS UNIVERSITY; WASHINGTON UNIVERSITY; MEYERS, Marvin, J.; SINGH, Megh; STALLINGS, Christina, L.; WEISS, Leslie, A.; WILDMAN, Scott; ARNETT, Stacy, D.; (134 pag.)WO2019/18359; (2019); A1;,
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