Category: 39876-88-5

Application of 39876-88-5, Adding some certain compound to certain chemical reactions, such as: 39876-88-5, name is 4-Chlorobenzofuro[3,2-d]pyrimidine,molecular formula is C10H5ClN2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39876-88-5.

In a pressure vessel equipped with a magnetic stirring bar was added (4-bromo-2,6-difluorophenyl)methanamine.HC1 (1 g, 3.87 mmol), and 4-chlorobenzofuro[3,2-djpyrimidine (0.792 g, 3.87 mmol) in acetonitrile (20 mL). Hunig?s base (2.70 mL, 15.47 mmol) was added and the mixture was heated to 80 C in a preheated oil bath and allowed to stir for 48 hours overnight. Cool to RT and filter formed solids, wash with excess acetonitrile, filter and dry under vacuum to give 863 mg (5 7%) of N-(4-bromo-2,6-difluorobenzyl)benzofuro[3,2-djpyrimidin-4-amine as a fluffy white solid. LCMS (M+1) = 389.6 and 391.6.

According to the analysis of related databases, 39876-88-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; BELEMA, Makonen; BOWSHER, Michael S.; DESKUS, Jeffrey A; EASTMAN, Kyle J.; GILLIS, Eric P; FRENNESSON, David B; IWUAGWU, Christiana; KADOW, John F.; NAIDU, B. Narasimhulu; PARCELLA, Kyle E.; PEESE, Kevin M; SAULNIER, Mark G; SIVAPRAKASAM, Prasanna; (463 pag.)WO2018/127800; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 39876-88-5, Adding some certain compound to certain chemical reactions, such as: 39876-88-5, name is 4-Chlorobenzofuro[3,2-d]pyrimidine,molecular formula is C10H5ClN2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39876-88-5.

4-Chlorobenzofuro[3,2-djpyrimidine (500 mg, 2.44 mmol), 6-methyl-2-vinyl-1,3 ,6,2-dioxazaborocane-4,8-dione (492 mg, 2.69 mmol), chloro(2-dicyclohexylphosphino-2?,6?-dimethoxy- 1,1 ?-biphenyl) [2-(2?-amino- 1,1?-biphenyl)jpalladium(II) (176 mg, 0.244 mmol), potassium phosphate tribasic (3.89 g, 18.3 mmol) were combined under N2 (g). 1,4-Dioxane (20 ml) and water (4.0 ml) was added under N2 (g). The reaction was stirred at 80 C for 1 hr. The reaction was concentrated, adsorbed onto celite and was purified on silica gel (Biotage,EtOAc/hexanes gradient, 0-100% over 10 CVs) to give the expected product 4- vinylbenzofuro[3,2-djpyrimidine (254 mg, 1.30 mmol, 53.0 % yield) LCMS (M+H) =196.80.

According to the analysis of related databases, 39876-88-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; BELEMA, Makonen; BOWSHER, Michael S.; DESKUS, Jeffrey A; EASTMAN, Kyle J.; GILLIS, Eric P; FRENNESSON, David B; IWUAGWU, Christiana; KADOW, John F.; NAIDU, B. Narasimhulu; PARCELLA, Kyle E.; PEESE, Kevin M; SAULNIER, Mark G; SIVAPRAKASAM, Prasanna; (463 pag.)WO2018/127800; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 39876-88-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 39876-88-5, name is 4-Chlorobenzofuro[3,2-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

N-(3-(9H-carbazol-3-yl)phenyl)-N-phenyldibenzo[b,d]furan-2-amine (2.5 g, 5.0 mmol) and sodium hydride (0.34 g, 8.5 mmol) were mixed in 30 mL of dry DMF. The solution was stirred for 1 hour at room temperature. 4-chlorobenzofuro[3,2-d]pyrimidine (1.9 g, 9.5 mmol) was added. The mixture was stirred overnight under nitrogen. The reaction mixture was poured into water and the precipitate was filtered. The residue was then purified by column chromatography using THF:hexane (1:3, v/v) as the eluent. 2.4 g (74%) of a pale yellow solid was obtained as the product.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 39876-88-5, 4-Chlorobenzofuro[3,2-d]pyrimidine.

Reference:
Patent; Universal Display Corporation; Joseph, Scott; Kwang, Raymond; Lee, Chi Hang; Shia, Chuan Jun; Ram, SiV Cheung; (131 pag.)KR2015/9461; (2015); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 39876-88-5, 4-Chlorobenzofuro[3,2-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 39876-88-5, blongs to pyrimidines compound. Formula: C10H5ClN2O

Synthesis Example 2 Synthesis of 4Pcczbfpm First, 0.15 g (3.6 mmol) of sodium hydride (60%) was put into a three-neck flask the air in which was replaced with nitrogen, and 10 mL of N,N-dimethylformamide (abbreviation: DMF) was dropped thereinto while stirring was performed. The container was cooled down to 0 C., a mixed solution of 1.1 g (2.7 mmol) of 9-phenyl-3,3′-bi-9H-carbazole and 15 mL of DMF was dropped thereinto, and stirring was performed at room temperature for 30 minutes. Then, the container was cooled down to 0 C., a mixed solution of 0.50 g (2.4 mmol) of 4-chloro[1]benzofuro[3,2-d]pyrimidine and 15 mL of DMF was added, and stirring was performed at room temperature for 20 hours. The resulting reaction solution was put into ice water and toluene was added to the mixture. An organic layer was extracted from the resulting mixture with the use of ethyl acetate and washed with saturated brine. Magnesium sulfate was added and filtration was performed. The solvent of the obtained filtrate was distilled oil and purification was conducted by silica gel colunm chromatography (developing solvent: toluene, and then a mixed solvent of toluene:ethyl acetate=1 :20). Recrystallization using a mixed solvent of toluene and hexane was performed, so that 1.0 g of 4PCCz8fpm, which was the target substance, was obtained as a yellowish white solid in a yield of 72%. Then, 1.0 g of the yellowish white solid was purified using a train sublimation method. In the purification by sublimation, the yellowish white solid was heated at 270 C. to 280 C. with the pressure set at 2.6 Pa and the argon gas flow rate set at 5 mE/mm After the purification by sublimation, 0.7 g of a yellowish white solid, which was the target substance, was obtained at a collection rate of 69%. The synthesis scheme of this step is shown in(A-2) below. Analysis results by nuclear magnetic resonance (?H-NMR) spectroscopy of the yellowish white solid obtained in the above step are described below. These results reveal that 4PCCz8fpm was obtained. ?H-NMR oe(CDC13): 7.31-7.34 (m, 1H), 7.43-7.46 (m, 3H), 7.48-7.54 (m, 3H), 7.57-7.60 (t, 1H), 7.62-7.66 (m, 4H), 7.70 (d, 1H), 7.74-7.77 (dt, 1H), 7.80 (dd, 1H), 7.85 (dd, 1H), 7.88-7.93 (m, 2H), 8.25 (d, 2H), 8.37 (d, 1H), 8.45 (ds, 1H), 8.49 (ds, 1H), 9.30 (s, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,39876-88-5, its application will become more common.

Reference:
Patent; Semiconductor Energy Laboratory Co., Ltd.; Seo, Satoshi; WATABE, Takeyoshi; MITSUMORI, Satomi; (178 pag.)US2017/92890; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 39876-88-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.39876-88-5, name is 4-Chlorobenzofuro[3,2-d]pyrimidine, molecular formula is C10H5ClN2O, molecular weight is 204.61, as common compound, the synthetic route is as follows.

A mixture of 4-chlorobenzofuro[3,2-djpyrimidine (1.01 g, 4.94 mmol) and (4-bromo-2-fluorophenyl)methanamine (1.04 g, 5.10 mmol) in acetonitrile (50 mL) in apressure bottle was treated with Hunig?s base (1.6 mL, 9.16 mmol) and the resulting suspension stirred at RT for 10 mm, then heated to 120 C in an oil bath. After 5 hours the mixture went into solution and was then stirred for 16 hours overnight. A pale yellow solid had formed while at 120 C, then the reaction mixture was cooled to RT. Themixture was filtered and washed with CH3CN, and was dried under vacuum to give 1.43 g (78%) ofN-(4-bromo-2-fluorobenzyl)benzofuro[3,2-djpyrimidin-4-amine as a pale yellow solid. LCMS (M+1) = 371.6/373.6.

The chemical industry reduces the impact on the environment during synthesis 39876-88-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; BELEMA, Makonen; BOWSHER, Michael S.; DESKUS, Jeffrey A; EASTMAN, Kyle J.; GILLIS, Eric P; FRENNESSON, David B; IWUAGWU, Christiana; KADOW, John F.; NAIDU, B. Narasimhulu; PARCELLA, Kyle E.; PEESE, Kevin M; SAULNIER, Mark G; SIVAPRAKASAM, Prasanna; (463 pag.)WO2018/127800; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 39876-88-5, 4-Chlorobenzofuro[3,2-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyrimidines, blongs to pyrimidines compound. category: pyrimidines

First of all, 2.42 g of 4-chlorobenzofuran [3, 2-d]pyrimidine, 2.19 g of phenylboronic acid, 1.89 g of sodium carbonate, 0.10 g of bis(triphenylphosphine)palladium chloride(II) (abbreviation: Pd(PPh3)2Cl2), 20 mL of water and 201 mL of acetonitrile were placed in an eggplant type flask equipped with a reflux tube, and the interior of the flask was replaced with argon gas. The reaction vessel was irradiated with microwaves (2.45 GHz, 100 W) for 60 minutes to heat. Then, the obtained residue was filtered with water and washed with hexane. With hexane: The obtained solid was purified by flash column chromatography of ethyl acetate = 2:1 to eluent solvent to give the desired pyrimidine derivative Hpbf pm (white powder, yield 45%). Further, microwaves were irradiated using a microwave synthesizer (manufactured by CEM Corporation, Discover).

The synthetic route of 39876-88-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Co., Ltd. Semiconductor Energies Institute; Jing Shangyingzi; Shan Kouzhiye; Lai Weiguangmei; Lai Weizheshi; (69 pag.)CN103450279; (2018); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 39876-88-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 39876-88-5, name is 4-Chlorobenzofuro[3,2-d]pyrimidine, molecular formula is C10H5ClN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Finally, 3- [6- (9,9-dimethyl-fluoren-2-yl) dibenzothiophene-4-yl] phenyl boronic acid pinacol ester 0.45g, 4- chlorobenzoate furo [3,2-d ] pyrimidine 0.14g, flask, 0.45g potassium phosphate, dioxane, 4mL, 0.16g t- butanol, a three-necked, flask was replaced air by nitrogen;Then, 1.8mg of palladium acetate, di (1-adamantyl) -n- butyl phosphine was added to 5.6mg pin, and the mixture was allowed to promote the reaction to reflux.Water was added to the obtained mixture, and the solution was extracted with ethyl acetate.Washed with saturated aqueous sodium chloride, the addition of magnesium sulfate, and filtered nature.Removing the solvent of the filtrate was evaporated, toluene: hexane = 1: 5 by purifying the (volume ratio) by flash column chromatography using as a developing solvent to obtain a yellow solid in a yield of 10%.It shows a synthetic scheme of Step 5 in the formula (e-3).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 39876-88-5, 4-Chlorobenzofuro[3,2-d]pyrimidine.

Reference:
Patent; Handotai Enerugi Ken kyushu Corporation; Inoue, Hideko; Ghanamoto, Miki; Seo, Hiromi; Takahashi, Tsuyoshi; Nakagawa, Tomoka; (80 pag.)KR2015/132837; (2015); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 39876-88-5, Adding some certain compound to certain chemical reactions, such as: 39876-88-5, name is 4-Chlorobenzofuro[3,2-d]pyrimidine,molecular formula is C10H5ClN2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39876-88-5.

1-bromo-9H- carbazole (5.0 g, 20.3 mmol) and sodium hydride (1.4 g, 34.5 mmol) were mixed in 200 mL of dry DMF. The solution was stirred for 4 hours and the addition of 4-chlorobenzofuro[3,2-d]pyrimidine(7.9 g, 38.6 mmol). The mixture was refluxed under nitrogen overnight. The reaction mixture was placed in water and the precipitate was then filtered off. After the residue with eluent THF: hexane (1: 1, v / v) was purified by column chromatography using. Of the yellow product was collected 4 .1 g (49%).

According to the analysis of related databases, 39876-88-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Universal Display Corporation; Joseph, Scott; Kwang, Raymond; Lee, Chi Hang; Shia, Chuan Jun; Ram, SiV Cheung; (131 pag.)KR2015/9461; (2015); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia