Category: 39889-94-6

Electric Literature of 39889-94-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 39889-94-6 as follows.

Intermediate 174A (10mg, 0.021 mmol) in dichloromethane (1 mL) was added to a solution of 2-methylpyrimidin-5-amine (4.61 mg, 0.042 mmol) and pyridine (0.017 ml, 0.211 mmol) in dichloromethane (0.5 mL) dropwise. The reaction mixture was stirred at room temperature for 0.5 h, at which time LCMS and HPLC indicated a completion of reaction. The reaction mixture was diluted with EtOAc, washed with 0.5 N HC1. The organic layer was washed with brine, dried over sodium sulfate and concentrated. Thecrude was dissolved in DMSO and purified via preparative LC/MS (Method D: Gradient:45-90% B over 10 minutes, then a 5-minute hold at 100% B). Fractions containing the desired product were combined and dried via centrifugal evaporation to Example 174 (7.8 mg, 0.014 mmol, 67.6 % yield). ?H NMR (500MHz, DMSO-d6) 10.02 (br. s., 1H), 8.72 (s, 3H), 8.56 (s, 1H), 7.85 (d, J=11.3 Hz, 1H), 7.81 (s, 1H), 4.49-4.32 (m, 2H), 4.07 (s,3H), 3.57-3.29 (m, 2H), 2.62 (s, 3H), 2.54 (s, 3H), 1.60 (s, 3H). LC-MS: Method L, 0 to100% B. RT = 2.27 mm, MS (ESI) m/z: 547.15 (M+H). Analytical HPLC purity (method B): 100%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,39889-94-6, its application will become more common.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; ZHANG, Xiaojun; PRIESTLEY, Eldon Scott; HALPERN, Oz Scott; JIANG, Wen; REZNIK, Samuel Kaye; RICHTER, Jeremy M.; (545 pag.)WO2018/13776; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39889-94-6, name is 5-Amino-2-methylpyrimidine, the common compound, a new synthetic route is introduced below. Application In Synthesis of 5-Amino-2-methylpyrimidine

Intermediate 103A (170 mg) in DCM (2 mL) was added to 2-methylpyrimidin-5-amine (46.2 mg, 0.423 mmol) in DCM (1 mL), followed by addition of pyridine (0.14 mL, 1.76 mmol). The reaction mixture was stirred at room temperature for lh, at which time LCMS indicated a completion of reaction. The reactionmixture was diluted with EtOAc, washed with 0.5 N HC1. The organic layer was washed with brine, dried over sodium sulfate and concentrated. The crude was dissolved in DMSO and purified via preparative LC/MS (method A, 50-100% B over 10 minutes, then a 2-minute hold at 100% B). Fractions containing the desired product were combined and dried via centrifugal evaporation to yield Example 103 (80 mg, 43% yield) as a solid. ?HNMR (400MHz, chloroform-d) 8.78 (s, 2H), 8.63 (d, J1.5 Hz, 1H), 8.56 (s, 1H), 7.77(d, J0.9 Hz, 1H), 7.69 (d, J8.6 Hz, 1H), 7.13 (d, J=8.8 Hz, 1H), 4.64-4.49 (m, 4H), 4.32(dd, J=11.4, 6.6 Hz, 1H), 4.14 (s, 3H), 2.73 (s, 3H), 2.66 (s, 3H). LC-MS: method C, RT= 2.37 mm, MS (ESI) mlz: 531.1 (M+H) Analytical HPLC purity: 95%.

The synthetic route of 39889-94-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; ZHANG, Xiaojun; PRIESTLEY, Eldon Scott; HALPERN, Oz Scott; JIANG, Wen; REZNIK, Samuel Kaye; RICHTER, Jeremy M.; (545 pag.)WO2018/13776; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 39889-94-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 39889-94-6, name is 5-Amino-2-methylpyrimidine, molecular formula is C5H7N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

The mixture of mono-sufone (50.6 mg, 0.1 mmol), 2-methylpyrimidin-5-amine (109 mg, 1.0 mmol), and K2CO3 (138.1 mg, 1.0 mmol) in NMP (0.5 mL) was heated to 140 C for 17 hrs, cooled to room temperature, and TFA (15 mL) was added and stirred for 5 minutes. After removal of the solvent, prep-HPLC of the residue gave the desired product. MS (ESI) m/z 435 (M + H)+.

According to the analysis of related databases, 39889-94-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TRIUS THERAPEUTICS, INC.; FINN, John; TARI, Leslie, William; CHEN, Zhiyong; ZHANG, Junhu; PHILLIPSON, Douglas; LEE, Suk, Joong; TRZOSS, Michael; BENSEN, Daniel; LI, Xiaoming; TENG, Min; ONG, Voon; BORCHARDT, Allen, John; LAM, Thanh, To; WO2015/38661; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia