Category: 39906-04-2

Electric Literature of 39906-04-2, Adding some certain compound to certain chemical reactions, such as: 39906-04-2, name is 4,6-Dichloro-2-methylpyrimidin-5-amine,molecular formula is C5H5Cl2N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39906-04-2.

General procedure: A microwave vial was charged with the corresponding aniline (1 , 1 .0 mmol), the 4,6-dichloropyrimidine (2, 1 .0 mmol), isobutanol (2.5 mL) and 37% aqueous HCI (0.07 mL/mmol). The reaction vessel was sealed and heated in a microwave reactor at 150 C for 10-30 min. After cooling, the reaction mixture was worked up as indicated in each case. Following the general procedure, a microwave vial was charged with 5-amino- 4,6-dichloro-2-methylpyrimidine (200 mg, 0.48 mmol), 3-chloroaniline (50 muIota_, 0.48 mmol), isobutanol (1 .2 mL) and 37% aqueous HCI (36 muIota_). After cooling, the product was isolated by filtration and dried to obtain 120 mg (93%) of 3c as a brown solid. Mp: 239-241 C. MS (ES, positive mode): m/z 269 (M+H)+with a 2 CI isotopic pattern. 1 H NMR (DMSO-d6, 300 MHz): delta 2.33 (s, 3H, CH3), 6.38 (s, 2H, NH2), 7.05 (ddd, J = 8.0, 2.0, 0.8 Hz, 1 H, H-4′), 7.33 (pt, J = 8.1 Hz, 1 H, H-5′), 7.73 (ddd, J = 8.3, 2.0, 0.8 Hz, 1 H, H-6′), 7.99 (pt, J = 2.1 Hz, 1 H, H-2′), 9.1 1 (s, 1 H, NH).

According to the analysis of related databases, 39906-04-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; KATHOLIEKE UNIVERSITEIT LEUVEN; CONSEJO SUPERIOR DE INVESTIGACIONS CIENTIFICAS (CSIC); PEREZ PEREZ, Maria Jesus; GIGANTE MARTINEZ, Alba; CANELA GOMEZ, Maria Dolores; LEYSSEN, Pieter; NEYTS, Johan; WO2014/170368; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 39906-04-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 39906-04-2, name is 4,6-Dichloro-2-methylpyrimidin-5-amine, molecular formula is C5H5Cl2N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A microwave vial was charged with 3′-aminoacetanilide 29 (300 mg, 2.0 mmol), 5-amino-4,6-dichloropyrimidine (10) (328 mg, 2.0 mmol), acetic acid (100 muL) and isobutanol (10 mL) and was irradiated at 150 C for 30 min. After cooling, dichloromethane was added (20 mL) and the crude reaction mixture was washed with saturated aqueous NaHCO3 (20 mL). The organic layer was dried over Na2SO4, filtered and evaporated to dryness. The residue was purified by flash chromatography (dichloromethane:methanol).Yield: 300 mg (54%).

According to the analysis of related databases, 39906-04-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Aguado, Leire; Canela, Maria-Dolores; Thibaut, Hendrik Jan; Priego, Eva-Maria; Camarasa, Maria-Jose; Leyssen, Pieter; Neyts, Johan; Perez-Perez, Maria-Jesus; European Journal of Medicinal Chemistry; vol. 49; (2012); p. 279 – 288;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 39906-04-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.39906-04-2, name is 4,6-Dichloro-2-methylpyrimidin-5-amine, molecular formula is C5H5Cl2N3, molecular weight is 178.02, as common compound, the synthetic route is as follows.

General procedure: A microwave vial was charged with the corresponding 4,6-dichloropyrimidine (1.0 mmol), the appropriate arylamine (1.0 mmol), 4 mL of isobutanol and 50 muL of 37% aqueous HCl. The reaction vessel was sealed and heated in a microwave reactor at 150 C for 10 min. After cooling, the reaction mixture was worked up as indicated in each case.

The chemical industry reduces the impact on the environment during synthesis 39906-04-2, I believe this compound will play a more active role in future production and life.

Reference:
Article; Aguado, Leire; Canela, Maria-Dolores; Thibaut, Hendrik Jan; Priego, Eva-Maria; Camarasa, Maria-Jose; Leyssen, Pieter; Neyts, Johan; Perez-Perez, Maria-Jesus; European Journal of Medicinal Chemistry; vol. 49; (2012); p. 279 – 288;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 39906-04-2, Adding some certain compound to certain chemical reactions, such as: 39906-04-2, name is 4,6-Dichloro-2-methylpyrimidin-5-amine,molecular formula is C5H5Cl2N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39906-04-2.

A microwave vial was charged with 5-amino-4,6-dichloro-2-methyl-pyrimidine (4) (700 mg, 3.91 mmol), 4-methoxybenzylamine (510 ml, 3.91 mmol), and K2CO3 (810 mg,5.86 mmol) in anhydrous DMF (10 mL). The vessel was sealed and irradiated at 150 C for 1 h. After cooling, dichloromethane was added (20 mL) and the crude reaction mixture was washed with saturated aqueous NH4Cl (15 mL). The organic layer was dried over Na2SO4, filtered and evaporated to dryness. The residue was purified by flash chromatography (dichloromethane:methanol 20:1) to yield 696 mg (64%) of 11 as a yellow solid. Mp 155-157 C. MS (ES, positive mode):m/z 279 (M+H)+ with a Cl isotopic pattern. 1H NMR (DMSO-d6, 300 MHz) delta: 2.52 (s, 3H, CH3-2), 2.68 (s, 3H, CH3-8), 3.71(s, 3H, OCH3), 5.39 (s, 2H, CH2), 6.89 (d, 2H, J=8.6 Hz, Ar), 7.17 (d,2H, J=8.5 Hz, Ar).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 39906-04-2, 4,6-Dichloro-2-methylpyrimidin-5-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Canela, Mara-Dolores; Liekens, Sandra; Camarasa, Mara-Jos; Priego, Eva Mara; Prez-Prez, Mara-Jess; European Journal of Medicinal Chemistry; vol. 87; (2014); p. 421 – 428;,
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Pyrimidine – Wikipedia

Synthetic Route of 39906-04-2 , The common heterocyclic compound, 39906-04-2, name is 4,6-Dichloro-2-methylpyrimidin-5-amine, molecular formula is C5H5Cl2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Compound 1 (800 mg, 4.48 mmol) and benzenamine (510 mg, 5.44 mmol) were suspended in EtOH/H2O (30 mL, 1:8). Concentrated hydrochloric acid (0.5 mL) was added at room temperature followed by warming reaction to reflux. After stirring for 10 h the reaction was cooled to room temperature and stirred for 6 h. The precipitate was collected on a sintered glass funnel and rinsed with water (10 mL) followed by hexanes (10 mL). After drying in vacuo, Compound 2a (850 mg) was obtained. Yield: 81%; gray solid. MS (EI) m/z (%)=234 (M+).

The synthetic route of 39906-04-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Xu, Dan; Sun, Li-Ping; You, Qi-Dong; Tetrahedron; vol. 68; 22; (2012); p. 4248 – 4251;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 39906-04-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 39906-04-2, name is 4,6-Dichloro-2-methylpyrimidin-5-amine, molecular formula is C5H5Cl2N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

As shown in step 10-v of Scheme 10, to a solution of 4,6-dichloro-2-methyl-pyrimidin-5-amine (14.04 g, 78.88 mmol) stirred in methanol-d4 (140.4 mL) was added formic acid-d2 (7.77 g, 161.7 mmol) and Pd black (765 mg, 7.19 mmol, wetted in methanol-d4), followed by triethylamine (16.36 g, 22.53 mL, 161.7 mmol). The reaction mixture was sealed in a tube and stirred at RT overnight. The mixture was then filtered and concentrated under reduced pressure. Et2O (250 mL) was added and the mixture stirred for 1 hour at RT. The resulting solids were filtered and washed with Et2O (*2). The filtrate was concentrated under reduced pressure to yield 4,6-dideutero-2-methyl-pyrimidin-5-amine (compound 2043, 5.65 g, 65% yield) as a light yellow solid: 1H NMR (300 MHz, DMSO-d6) delta 5.25 (s, 2H), 2.40 (s, 3H). This compound was used in subsequent steps without further purification.

According to the analysis of related databases, 39906-04-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Charifson, Paul S.; Cottrell, Kevin Michael; Deng, Hongbo; Duffy, John P.; Gao, Huai; Giroux, Simon; Green, Jeremy; Jackson, Katrina Lee; Kennedy, Joseph M.; Lauffer, David J.; Ledeboer, Mark Willem; Li, Pan; Maxwell, John Patrick; Morris, Mark A.; Pierce, Albert Charles; Waal, Nathan D.; Xu, Jinwang; US2013/281431; (2013); A1;,
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Pyrimidine – Wikipedia

Related Products of 39906-04-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 39906-04-2 as follows.

Reference Example 4-2 Preparation of 6-chloro-N4-cyclohexyl-2-methylpyrimidine-4,5-diamine A mixture of 5-amino-4,6-dichloro-2-methylpyrimidine (1.0 g), cyclohexylamine (770 muL), N,N-diisopropylethylamine (1.2 mL), and N-methylpyrrolidone (5 mL) was stirred at 120 C. overnight. To the reaction mixture were additionally added cyclohexylamine (770 muL) and N,N-diisopropylethylamine (1.2 mL), and the resulting mixture was stirred at 120 C. overnight. The reaction mixture was allowed to cool to room temperature, water was added thereto, and the resulting mixture was extracted twice with ethyl acetate. The resulting organic layers were combined, washed with saturated brine, dried over anhydrous magnesium sulfate, and the insoluble matters were removed by filtration. The resulting filtrate was concentrated under reduced pressure, and the resulting residues were purified by silica gel column chromatography (solvent: hexane/ethyl acetate=90/10 to 70/30) to give the title compound (1.35 g) (yield 100%) as a brown powder. MS(APCI) m/z: 241/243 [M+H]+

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,39906-04-2, its application will become more common.

Reference:
Patent; MITSUBISHI TANABE PHARMA CORPORATION; UBE INDUSTRIES, LTD.; NAKAJIMA, Tatsuo; HAYASHI, Norimitsu; ISHIZAWA, Kouhei; TSUZAKI, Yasunori; IWAMURA, Ryo; TSUBOIKE, Kazunari; US2019/185479; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39906-04-2, name is 4,6-Dichloro-2-methylpyrimidin-5-amine, the common compound, a new synthetic route is introduced below. name: 4,6-Dichloro-2-methylpyrimidin-5-amine

Preparation 1 6-Chloro-N*4*-(4-methoxyphenyl)-2-methylpyrimidine-4,5-diamine; 4,6-dichloro-2-methyl-pyrimidin-5-ylamine (985.3 g, 5.53 MoI) was added with stirring to a 2OL reactor charged with EtOH (4.0 L) over 3 minutes to give complete solution. p-Anisidine (718.0 g, 5.83 MoI) was then added with stirring over 3 minutes. A dark brown solution was observed and addition of both reagents gave an exotherm of 130C. EtOH (1 L) was then added followed by a premixed solution of c.HCI (0.5 L) in EtOH (2 L) at a steady rate over 40 minutes. A slight exotherm up to approx 2O0C was noted. The solution was then warmed to 8O0C and held at that temperature for 3.5 hours during which a grey precipitate appeared. Heating was continued for a further 2 hours then the temperature was reduced to 490C, and stirring was continued for 19 hours. The reaction mixture was allowed to cool to 3O0C, before draining out of 2OL reactor. The reaction mixture was filtered to collect a beige precipitate. Washed with EtOH (2.5 L), the MTBE (2.5 L) and sucked dry under N2(g) for 22 hours. The filter cake was then dried under vacuum at 5O0C for 60 hours, to yield title compound, as the hydrochloride salt, as a beige solid (1.465 Kg, 88%). 1H NMR (400MHz, DMSO-d6) delta = 2.27 (s, 3H), 3.71 (s, 3H), 6.90 (d, 2H), 7.58 (d, 2H), 9.10 (bs, 1 H). LCMS (System 4): 2.4 mins m/z (APCI) 265 [MH+]

The synthetic route of 39906-04-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER LIMITED; WO2009/144632; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 39906-04-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 39906-04-2, name is 4,6-Dichloro-2-methylpyrimidin-5-amine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a solution of 5-amino-4,6-dichloro-2-methyl-pyrimidine (5.6mmol) in acetonitrile (20mL), Cs2CO3 (11.2mmol) and the suitable arylisothiocyanate (5.6mmol) were added. The suspension was stirred at 50C until disappearance (5-30h) of the starting materials (TLC monitoring: eluting system ciclohexane/ethyl acetate 7:3). Then, another 50mL of acetonitrile was added and the suspension was heated at 50C and filtered while hot. The filtrate, after the addition of 5g of silica gel (70-230 mesh), was stirred at room temperature for 20min and filtered. The solvent was removed in vacuum, and the residue was collected and recrystallized.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 39906-04-2, 4,6-Dichloro-2-methylpyrimidin-5-amine.

Reference:
Article; Varano, Flavia; Catarzi, Daniela; Squarcialupi, Lucia; Betti, Marco; Vincenzi, Fabrizio; Ravani, Annalisa; Varani, Katia; Dal Ben, Diego; Thomas, Ajiroghene; Volpini, Rosaria; Colotta, Vittoria; European Journal of Medicinal Chemistry; vol. 96; (2015); p. 105 – 121;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 39906-04-2 ,Some common heterocyclic compound, 39906-04-2, molecular formula is C5H5Cl2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a mixture of 4,6-dichloro-2-methylpyrimidin-5amine(1 g, 5.62 mmol) and O-ethyl carbonisothiocyanatidate(0.66 ml., 5.62 mmol) was added toluene (2 mL) to wet thesolids completely. The mixture was placed on 1000 C. oil bathfor 1.5 hours, at which time, the mixture had seized to give asolid mass. The solids were cooled to ambient temperatureand triturated with ether, then the resulting solids were collectedby filtration to give ethyl 7-chloro-5-methylthiazolo[5,4-d]pyrimidin-2-ylcarbamate (1.08 g, 3.96 mmol, 70.5%yield).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 39906-04-2, 4,6-Dichloro-2-methylpyrimidin-5-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; COOK II, JAMES H; MCDONALD, IVAR M; KING, DALTON; OLSON, RICHARD E; WANG, NENGHUI; IWUAGWU, CHRISTIANA I; ZUSI, F.CHRISTOPHER; MACOR, JOHN E; (330 pag.)JP5714745; (2015); B2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia