Category: 39906-04-2

Adding a certain compound to certain chemical reactions, such as: 39906-04-2, 4,6-Dichloro-2-methylpyrimidin-5-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 39906-04-2, blongs to pyrimidines compound. HPLC of Formula: C5H5Cl2N3

2-Methyl-4,6-dichloro-5-aminopyrimidine (Aldrich, 1.05 g) and ammonium hydroxide(3.0 mL, J.T. Baker, Phillipsburg, NJ, 28.0% – 30.0 %) were placed in a microwave vial. The vial was sealed and heated in a CEM microwave reactor (CEM Corporation, Matthews, NC) at120 0C and 40 Watts for 25 minutes. The reaction mixture was cooled to room temperature. This procedure was repeated a total of nine times using the following amounts of 2-methyl-4,6- dichloro-5-aminopyrimidine under the same reaction conditions:Run 2: 1.027 g. 2.5 mL ammonium hydroxide.Run 3: 1.034 g, 2.5 mL ammonium hydroxide.Run 4: 1.118 g, 2.6 mL ammonium hydroxide. Run 5 : 1.117 g, 2.5 mL ammonium hydroxide.Run 6: 1.149 g, 2.7 mL ammonium hydroxide.Run 7: 1.264 g, 2.6 mL ammonium hydroxide.Run 8: 1.106 g, 2.6 mL ammonium hydroxide.Run 9: 1.075 g, 2.7 mL ammonium hydroxide.All the runs were combined and concentrated to give 6-chloro-2-methylpyrimidine-4,5-diamin. MS (ESI pos. ion) m/z: 159. Calcd. MS: 158.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,39906-04-2, its application will become more common.

Reference:
Patent; AMGEN INC.; BODE, Christiane; BOEZIO, Alessandro; CHENG, Alan, C.; CHOQUETTE, Deborah; COATS, James, R.; COPELAND, Katrina, W.; HUANG, Hongbing; LA, Daniel; LEWIS, Richard; LIAO, Hongyu; POTASHMAN, Michele; STELLWAGEN, John; YI, Shuyan; NORMAN, Mark; STEC, Markian; PETERSON, Emily, A.; GRACEFFA, Russell; WO2010/132598; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 39906-04-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.39906-04-2, name is 4,6-Dichloro-2-methylpyrimidin-5-amine, molecular formula is C5H5Cl2N3, molecular weight is 178.02, as common compound, the synthetic route is as follows.

Example 77 (1 S,2R)-2-(4-(diisobutylamino)-3-(3-(2-methylpyrimidin-5-yl)ureido)phenyl)cyclopropanecarboxylic acid 77A. 2-methylpyrimidine-5-amineA solution of 4,6-dichloro-2-methylpyrimidin-5-amine (2 g, 11.23 mmol) in ethylether (93 ml) was treated with sodium hydroxide (7.37 g, 184 mmol) in water (22.05 ml)and 10% palladium on carbon (0.161 g, 1.5 17 mmol). The mixture was shaken at rt on aParr shaker under 50 psi of H2 gas for 22 h. The reaction was filtered through Celite andthe filter cake was washed with DCM. The solvent from the filtrate was evaporated togive a yellow residue. The suspension was re-dissolved in DCM and water. The aqueous layer was neutralized to approximately pH 6 with 4N HC1, then extracted with DCM (3X). The combined organic phases were dried over anhydrous Na2SO4, filtered, and concentrated to afford a yellow residue. The aqueous phase still contained product, so thewater was evaporated to give a yellow solid. The solid was taken up in MeOH and DCM and filtered to remove all salts. The filtrate was evaporated to give a yellow residue. A total of two crops were obtained – one from the extraction and one from the aqueous layer. Each crop was purified by flash chromatography and combined to give 77A (off- white solid, 0.968 g, 8.87 mmol, 79 % yield). ?H NMR (400MHz, CHLOROFORM-d) oe8.14 (s, 2H), 3.60 (br. s., 2H), 2.61 (s, 3H).

The chemical industry reduces the impact on the environment during synthesis 39906-04-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; BALOG, James Aaron; HUANG, Audris; CHEN, Bin; CHEN, Libing; SEITZ, Steven P.; HART, Amy C.; MARKWALDER, Jay A.; WO2014/150677; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 39906-04-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 39906-04-2, name is 4,6-Dichloro-2-methylpyrimidin-5-amine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a solution of 5-amino-4,6-dichloro-2-methyl-pyrimidine (5.6mmol) in acetonitrile (20mL), Cs2CO3 (11.2mmol) and the suitable arylisothiocyanate (5.6mmol) were added. The suspension was stirred at 50C until disappearance (5-30h) of the starting materials (TLC monitoring: eluting system ciclohexane/ethyl acetate 7:3). Then, another 50mL of acetonitrile was added and the suspension was heated at 50C and filtered while hot. The filtrate, after the addition of 5g of silica gel (70-230 mesh), was stirred at room temperature for 20min and filtered. The solvent was removed in vacuum, and the residue was collected and recrystallized.

According to the analysis of related databases, 39906-04-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Varano, Flavia; Catarzi, Daniela; Squarcialupi, Lucia; Betti, Marco; Vincenzi, Fabrizio; Ravani, Annalisa; Varani, Katia; Dal Ben, Diego; Thomas, Ajiroghene; Volpini, Rosaria; Colotta, Vittoria; European Journal of Medicinal Chemistry; vol. 96; (2015); p. 105 – 121;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 39906-04-2, Adding some certain compound to certain chemical reactions, such as: 39906-04-2, name is 4,6-Dichloro-2-methylpyrimidin-5-amine,molecular formula is C5H5Cl2N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39906-04-2.

4-Chloro-6-(2-fluoro-4-trifluoromethyl-phenyl)-2-methyl-pyhmidin-5-ylamine (Intermediate compound 4) To a solution of commercially available 5-amino-4,6-dichloro-2- methylpyrimidine (2.500 g, 15.2444 mmol) in DME (100 ml) and water (20 ml), 2- fluoro-4-(thfluoromethyl)phenylboronic acid (3.1696 g, 15.2444 mmol) and sodium carbonate (4.847 g, 45.7332 mmol) were added. The reaction mixture was degassed and kept under nitrogen atmosphere during the entire course of the reaction. Palladium (II) (bistriphenylphosphine)dichlohde (0.535 g, 0.7622 mmol) was added and the resulting reaction mixture, heated at 9O0C for 8 hrs, was worked up by addition of water and extraction with AcOEt. The organic phase, dried over anhydrous MgSO4, afforded upon evaporation a dark oily residue (-4.5 g), which was purified by preparative HPLC, to afford 1.21 O g (-26% yield) of the pure title compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 39906-04-2, 4,6-Dichloro-2-methylpyrimidin-5-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NEUROSEARCH A/S; WO2009/112461; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 39906-04-2, Adding some certain compound to certain chemical reactions, such as: 39906-04-2, name is 4,6-Dichloro-2-methylpyrimidin-5-amine,molecular formula is C5H5Cl2N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39906-04-2.

Preparation 23 4-(5-amino-6-chloro-2-methyl-pyrimidin-4-ylamino)-3-fluoro -phenol; A 10ml flask was charged with EtOH (3ml_). 2-methyl-4,6-dichloro-5-aminopyrimidine was added (140mg, 1.89 mMol) followed by 4-amino-3-fluoro-phenol (100mg, 1.89 mMol) and HCI (2M aq, 0.787ml_, 3.78 mMol). The reaction mixture was heated at 850C under N2 for 6 hours. The reaction mixture was evaporated, partitioned between 10 ml sodium bicarbonate solution and 10 ml ethyl acetate, the aqueous was extracted again twice with 10 ml ethyl acetate, the organics were combined, dried over magnesium sulphate, filtered and evaporated to give a purple gum (416 mg, 82%).LCMS (System 4, acidic run): 2.02 mins m/z (APCI) = 269 [MH+]

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 39906-04-2, 4,6-Dichloro-2-methylpyrimidin-5-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PFIZER LIMITED; WO2009/144632; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 39906-04-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 39906-04-2, name is 4,6-Dichloro-2-methylpyrimidin-5-amine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a solution of 5-amino-4,6-dichloro-2-methyl-pyrimidine (5.6mmol) in acetonitrile (20mL), Cs2CO3 (11.2mmol) and the suitable arylisothiocyanate (5.6mmol) were added. The suspension was stirred at 50C until disappearance (5-30h) of the starting materials (TLC monitoring: eluting system ciclohexane/ethyl acetate 7:3). Then, another 50mL of acetonitrile was added and the suspension was heated at 50C and filtered while hot. The filtrate, after the addition of 5g of silica gel (70-230 mesh), was stirred at room temperature for 20min and filtered. The solvent was removed in vacuum, and the residue was collected and recrystallized.

According to the analysis of related databases, 39906-04-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Varano, Flavia; Catarzi, Daniela; Squarcialupi, Lucia; Betti, Marco; Vincenzi, Fabrizio; Ravani, Annalisa; Varani, Katia; Dal Ben, Diego; Thomas, Ajiroghene; Volpini, Rosaria; Colotta, Vittoria; European Journal of Medicinal Chemistry; vol. 96; (2015); p. 105 – 121;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 39906-04-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 39906-04-2, name is 4,6-Dichloro-2-methylpyrimidin-5-amine. This compound has unique chemical properties. The synthetic route is as follows.

4-Chloro-6-(4-methoxy-phenyl)-2-methyl-pyhmidin-5-ylamine (Intermediate compound6}To a solution of commercially available 5-amino-4,6-dichloro-2- methylpyrimidine (6.000 g, 33.7038 mmol) in DME (50 ml) and water (10 ml), 4- methoxy phenyl boronic acid (5.122 g, 33.7038 mmol) and sodium carbonate (7.144 g, 67.4076 mmol) were added. The reaction mixture was degassed and kept under nitrogen atmosphere during the entire course of the reaction. Palladium (II) (bistriphenylphosphine)dichloride (1.183 g, 1.6852 mmol) was added and the resulting reaction mixture, heated at 9O0C for 3 hours, was worked up by addition of water and extraction with AcOEt. The organic phase, dried over anhydrous MgSO4, afforded upon evaporation a residue (-6 g), which eluted through silica gel with 4% AcOEt in hexane gave 4.503 g (-75% yield) of the pure title compound as a yellow solid.

According to the analysis of related databases, 39906-04-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NEUROSEARCH A/S; WO2009/112461; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 39906-04-2, 4,6-Dichloro-2-methylpyrimidin-5-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C5H5Cl2N3, blongs to pyrimidines compound. HPLC of Formula: C5H5Cl2N3

NH3 (g) was bubbled into EtOH (60 mL) at -40 C for 0.5 h (15 Psi). Then 4,6- dichloro-2-methyl-pyrimidin-5-amine (5 g, 28.09 mmol, 1 eq) was added at 18 C, and the result reaction mixture was stirred at 120 C for 13.5 hr (15 Psi). The reaction mixture was concentrated under reduced pressure to remove EtOH. Compound 6-chloro-2-methyl- pyrimidine -4, 5-diamine (I-791) (5.8g) was obtained as a yellow solid. LCMS m/z 158.8 (M+1)+.

The synthetic route of 39906-04-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SITARI PHARMA, INC.; CAMPBELL, David; CHAPMAN, Justin; CHEUNG, Mui, H.; DIRAIMONDO, Thoams, R.; DURON, Sergio, G.; (615 pag.)WO2020/33784; (2020); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 39906-04-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 39906-04-2, name is 4,6-Dichloro-2-methylpyrimidin-5-amine. A new synthetic method of this compound is introduced below.

1- 7A-80) a 4, 6-Dichloro-2-methylpyrimidin-5-ylamine (100 mg, 0.56 MMOL) and 4-chlorophenylamine (86 mg, 0.68 MMOL) were combined in H20 (1.5 ml) and 10: 1 ethanol/HCI (0.24 ml) and heated to reflux for 6 h. The reaction mixture was cooled and H20 added to it. The product was collected by filtration and dried on high vacuum to give the desired compound 1- 7A-80) a as a tan solid (173 mg) that was carried on crude: +ESI MS (M+1) 269.2.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,39906-04-2, 4,6-Dichloro-2-methylpyrimidin-5-amine, and friends who are interested can also refer to it.

Reference:
Patent; PFIZER PRODUCTS INC.; WO2004/37823; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia