3993-78-0 | Pyrimidines

9/23 News Extended knowledge of 3993-78-0

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3993-78-0, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 3993-78-0, 2-Amino-4-chloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 3993-78-0, blongs to pyrimidines compound. Safety of 2-Amino-4-chloropyrimidine

Under argon atmosphere, 4-chloropyrimidin-2-amine 10d (0.61g, 4.72mmol,It was prepared by the method “WO2009158011, A1” disclosed in the patent application),Compound 10c (1.1g, 5.19mmol),[1,1?-bis (diphenylphosphino) ferrocene] palladium dichloride (173mg, 0.24mmol),Potassium carbonate (1.30 g, 9.44 mmol) was dissolved in 20 mL of a mixed solution of 1,4-dioxane and water (V / V = 5: 1), heated to 90 C, and stirred for 2 hours. Stop the reaction,It was cooled to room temperature, concentrated under reduced pressure, and the residue was purified with CombiFlash rapid preparator using eluent system A to obtain the title product 10e (753 mg), yield: 89.01%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3993-78-0, its application will become more common.

Reference:
Patent; Jiangsu Hengrui Pharmaceutical Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.; Lu Biao; Wang Shenglan; Zhang Caihua; He Feng; Tao Weikang; (36 pag.)CN110684020; (2020); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

14/9/2021 News New downstream synthetic route of 3993-78-0

Statistics shows that 3993-78-0 is playing an increasingly important role. we look forward to future research findings about 2-Amino-4-chloropyrimidine.

Synthetic Route of 3993-78-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3993-78-0, name is 2-Amino-4-chloropyrimidine, molecular formula is C4H4ClN3, molecular weight is 129.55, as common compound, the synthetic route is as follows.

General procedure: To a round-bottom flask was charged with the correspondingaromatic halogen (1.0 equiv), the corresponding boronic acid(1.05-1.25 equiv), Pd(dppf)Cl2 (0.05 equiv) and base Na2CO3 (2.0equiv) under nitrogen atmosphere, then 1,4-dioxane (14 mL) andwater (2 mL) were added and the vessel was immediately sealed tightly. The resulting mixture was heated at 95 C for a period time (usually 2-6 h) until the completion of the reaction as monitoredby TLC. The cooled mixture was diluted with water and exhaustively extracted with ethyl acetate (30 mL 3). The organic phase was washed by brine, dried over anhydrous Na2SO4, and evaporated under reduced pressure. The residue was purified by chromatography on silica gel using ethyl acetate/petroleum ether as the eluent to afford the products.

Statistics shows that 3993-78-0 is playing an increasingly important role. we look forward to future research findings about 2-Amino-4-chloropyrimidine.

Reference:
Article; Chen, Yadong; Dong, Ruinan; Duan, Chunqi; Huang, Jianhang; Jiang, Fei; Li, Hongmei; Li, Shuwen; Liu, Chenhe; Lu, Tao; Tang, Weifang; Wang, Xinren; Xu, Junyu; Zhang, Tianyi; Zhang, Yanmin; Zhu, Gaoyuan; Zhu, Yuqin; European Journal of Medicinal Chemistry; vol. 200; (2020);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

07/9/2021 News Share a compound : 3993-78-0

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3993-78-0, 2-Amino-4-chloropyrimidine, and friends who are interested can also refer to it.

Related Products of 3993-78-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3993-78-0, name is 2-Amino-4-chloropyrimidine. A new synthetic method of this compound is introduced below.

A mixture of 4-fluoropiperidine hydrochloride (4.9 g, 35.1 mmol), 4-chloropyrimidin-2-amine (5.00 g, 38.6 mmol) and potassium carbonate (14.6 g, 105 mmol) in N-methyl-2-pyrrolidinone (15.0 mL) was stirred under argon for 2 h at 120 C. The reaction mixture was cooled to room temperature, was poured into NaOH (1 M) and ice and was extracted twice with ethyl acetate. The organic layers were washed with brine, combined, dried over Na2SC>4, filtered and the volatiles were evaporated to yield 8.33 g of a light yellow waxy solid. The solid was triturated with tert. butyl methylether (-10 mL) and stirred for 30 min. Then the suspension was filtrated and dried under high vacuum to yield 6.38 g (83 %, contains residual N-methyl-2-pyrrolidinone) of a light yellow solid. MS: m/z = 197.5 (M+H)+ ; The product was obtained starting from 1 -(2-fluoroethyl)piperazine hydrochloride (705 mg, 3.55 mmol), 4-chloropyrimidin-2-amine (506 mg, 3.91 mmol) and potassium carbonate (1.47 g, 10.7 mmol) in N-methyl-2-pyrrolidinone (1.5 mL) according to the method described in example 2, step 1 after overnight heating as light brown solid (642 mg, 79 ). MS: m/z = 226.6 (M+H)+

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3993-78-0, 2-Amino-4-chloropyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GOBBI, Luca; KNUST, Henner; KOERNER, Matthias; MURI, Dieter; WO2014/187762; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

01/9/2021 News New downstream synthetic route of 3993-78-0

The synthetic route of 3993-78-0 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 3993-78-0, 2-Amino-4-chloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 3993-78-0, blongs to pyrimidines compound. Product Details of 3993-78-0

4-(lH-indol-l-yl)pyrimidin-2-amine (15a). A mixture of 2-amino-4-chloropyrimidine (0.206g, 1.590mmol), indole (0.372g, 3.180mmol) and Cs2C03 (1.550g, 4.77 mmol) in anhydrous DMF (1.6 ml) was stirred in a Biotage microwave reactor for lh at 110 C. After cooling to room temperature, the reaction mixture diluted with water (5ml) and extracted with ethyl acetate (2 x 10ml). The combined organic extracts were dried over Na2S04 and the solvent removed under reduced pressure. Chromatography on silica gel using the FlashM aster 3 purification station (AcOEt/Hexane) afforded 15a (0.125 g, 0.593 mmol, 37%) as an off-white solid. 1H NMR (400 MHz, OMSO-d6) delta 8.78 (d, 1H, J = 8.28 Hz), 8.23 (d, J = 5.64 Hz, 1H), 8.03 (d, J = 3.64 Hz, 1H), 7.59 (d, J = 7.76 Hz, 1H), 7.27-7.22 (m, 1H), 7.17 (t, J = 7.36 Hz, 1H), 6.93 (d, J = 5.92 Hz, 1H), (bs, 2H), 6.74 (d, J = 3.60 Hz, 1H); HRMS (ESI-ve) calculated for Ci2Hn 4 (M+H)+ 211.0978, found 211.0979.

The synthetic route of 3993-78-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE INC.; LAWRENCE, Nicholas, J.; SEBTI, Said, M.; PIREDDU, Roberta; WO2012/135697; (2012); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Analyzing the synthesis route of 2-Amino-4-chloropyrimidine

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3993-78-0, 2-Amino-4-chloropyrimidine.

Related Products of 3993-78-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3993-78-0, name is 2-Amino-4-chloropyrimidine, molecular formula is C4H4ClN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A light yellow suspension of 4-chloropyrimidin-2-amine (5.01 g, 38.7 mmol), pyrrolidine (2.50 g, 2.91 ml, 35.2 mmol) and potassium carbonate (9.72 g, 70.3 mmol) in N-methyl-2- pyrrolidinone (15.0 mL) was stirred under argon at 120 C for 2 h and at room temperature overnight. The reaction mixture was cooled to room temperature and was poured into NaOH (1 M, 200 mL) and ice. The aqueous layer was extracted with ethyl acetate (200 mL) whereof part of the product precipitated in the water phase. The precipitate was filtered, washed water, triturated with dichloromethane and dried to obtain 3.1 g product as white solid. The separated ethyl acetate phase was dried over MgS04, filtered and concentrated in vacuum. The resulting light yellow solid was triturated with dichloromethane and dried to obtain 1.1 g product as white solid. The aqueous phase was extracted with dichloromethane (3 x 100 mL), dried over MgS04, filtered and concentrated in vacuum. The resulting light yellow solid was triturated with dichloromethane to obtain another 0.52 g product as white solid. The dichloromethane layers were combined, concentrated in vacuum and the product was purified by flash chromatography (using silica gel and a dichloromethane/methanol/ammonia gradient) to yield another 0.46 g product as light yellow. In total 5.18 g (89.7 ) of a light yellow solid were obtained. MS: m/z = 165.3 (M+H)+

Extracurricular laboratory: Synthetic route of 3993-78-0

With the rapid development of chemical substances, we look forward to future research findings about 3993-78-0.

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3993-78-0, name is 2-Amino-4-chloropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. category: pyrimidines

With the rapid development of chemical substances, we look forward to future research findings about 3993-78-0.

Analyzing the synthesis route of 2-Amino-4-chloropyrimidine

The synthetic route of 3993-78-0 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3993-78-0, name is 2-Amino-4-chloropyrimidine, the common compound, a new synthetic route is introduced below. Formula: C4H4ClN3

[0879] To a mixture of 2-amino-4-chloro-pyrimidine 79 (10.2 g, 79 mmol) in methanol (140 mL) and acetonitrile (100 mL), N-bromosuccinimide (14.01 g, 79 mmol) was added, and the resulting mixture was stirred at RT for about 0.5 h. The reaction mixture was treated with Et2O (200 mL), then cooled to about 5 C. and stirred for about 1 h. The mixture was filtered and the product air dried to afford compound 134.

The synthetic route of 3993-78-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; INTELLKINE, LLC; INFINITY PHARMACEUTICALS, INC.; CASTRO, Alfredo C.; EVANS, Catherine A.; JANARDANANNAIR, Somarajannair; LESCARBEAU, Andre; LIU, Tao; SNYDER, Daniel A.; TREMBLAY, Martin R.; REN, Pingda; LIU, Yi; LI, Liansheng; CHAN, Katrina; US2013/53362; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Introduction of a new synthetic route about 3993-78-0

The synthetic route of 3993-78-0 has been constantly updated, and we look forward to future research findings.

NaH (1.15 g, 60% in mineral oil, 28.7 mmol) was added the mixture of 4-chloropyrimidin-2-amine (1.0 g, 7.75 mmol) and solketal (3.07 g, 23.25 mmol) in dioxane (12 mL) solution at 0 C. The temperature was elevated to 120 C for 15 h. After cooling to room temp, the solids were filtered, filtrate was concentrated and residue purified by column chromatography to give 4-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)pyrimidin-2- amine (1.2 g, 69 %). MS (ESI) calcd for C10H15N3O3: 225.11

The synthetic route of 3993-78-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SIRTRIS PHARMACEUTICALS, INC.; CASAUBON, Rebecca, L.; NARAYAN, Radha; OALMANN, Christopher; VU, Chi, B.; WO2013/59587; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Extracurricular laboratory: Synthetic route of 2-Amino-4-chloropyrimidine

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3993-78-0, its application will become more common.

Electric Literature of 3993-78-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3993-78-0, name is 2-Amino-4-chloropyrimidine. A new synthetic method of this compound is introduced below.

To a solution of 2-fluoro-5- (tetramethyl-l,3,2-dioxaborolan-2-yl)benzonitrile (1.71 g, 6.92 mmol) in dioxane (40 mL) was added 4-chloropyrimidin-2-amine (950 mg, 7.33 mmol), sodium carbonate solution (1.4 M in water, 10 mL, 14.00 mmol) and Pd(PCyg)2Ci2 (1.08 g, 1.47 mmol) at room temperature. The resulting mixture was stirred for 3 h at 100 C. When the reaction was done, the reaction mixture was concentrated under reduced pressure and the residue was purified by flash chromatography eluting with EtOAc in hexane (0 % to 100 % gradient) to yield 5-(2-aminopyrimidin-4-yl)-2- fluorobenzonitrile as an yellow solid (990 mg, 66 %). MS: m/z = 215.0 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3993-78-0, its application will become more common.

Reference:
Patent; MERCK PATENT GMBH; KARRA, Srinivasa R.; XIAO, YuFang; SHERER, Brian A.; (380 pag.)WO2019/79373; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The important role of 2-Amino-4-chloropyrimidine

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3993-78-0, its application will become more common.

Synthetic Route of 3993-78-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 3993-78-0 as follows.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3993-78-0, its application will become more common.