Category: 3993-78-0

Adding a certain compound to certain chemical reactions, such as: 3993-78-0, 2-Amino-4-chloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C4H4ClN3, blongs to pyrimidines compound. COA of Formula: C4H4ClN3

A microwave vial was charged with 4-chloropyrimidin-2-amine (300 mg, 2.32 mmol), isopropylamine (828 mg, 1.2 ml, 14.0 mmol) and water (1.0 mL). The vial was flushed with argon, closed and stirred at 180 C for 30 min under microwave irradiation (caution: the pressure reached >20 bar). The reaction mixture was cooled to room temperature and extracted with dichloromethane and water. The organic layer was washed with water and the aqueous layers were back-extracted with dichloromethane. The organic layers were combined, dried over Na2S04, filtered and concentrated. The product was obtained after triturating the residue with diethyl ether and a few drops of ethyl acetate as off-white solid (282 mg, 80 ).MS: m/z = 153.4 (M+H)+

The synthetic route of 3993-78-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GOBBI, Luca; KNUST, Henner; KOERNER, Matthias; MURI, Dieter; WO2014/187762; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3993-78-0, name is 2-Amino-4-chloropyrimidine, molecular formula is C4H4ClN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 3993-78-0

THF (20 mL) was added to a mixture of 4-chloro-2-aminopyrimidine (500 mg, 3.87 mmol) and N-Boc piperazine (7.21 g, 38.7 mmol). The reaction was stirred at 70 C. overnight. After cooling, the solvent was removed in vacuo and the remaining residue purified by silica gel chromatography (1:1 petroleum ether:ethyl acetate) to give tert-butyl 4-(2-aminopyrimidin-4-yl)piperazine-1-carboxylate (650 mg, 2.33 mmol, 60% yield). MS (ESI) calcd for C13H21N5O2: 279.2.

With the rapid development of chemical substances, we look forward to future research findings about 3993-78-0.

Reference:
Patent; BLUM, Charles A.; Caldwell, Richard Dana; Casaubon, Rebecca; Disch, Jeremy S.; Fox, Ryan Michael; Koppetsch, Karsten; Miller, William Henry; NG, Pui Yee; Oalmann, Christopher; Perni, Robert B.; Szczepankiewicz, Bruce G.; White, Brian; US2015/152108; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 3993-78-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3993-78-0, name is 2-Amino-4-chloropyrimidine, molecular formula is C4H4ClN3, molecular weight is 129.55, as common compound, the synthetic route is as follows.

A mixture of 2-amino-4-chloro-pyrimidine (7,5 mmol, 1g) with DMAP (0,2 eq, 1,5 mmol, 183,5 mg), triethylamine (0,2 eq, 1,5 mmol, 0,2 ml) and di-tert-butyl-dicarbonate (2 eq, 15 mmol, 3,2 g) in dichloromethane (60 mL) was stirred at room temperature for 48 h. When the reaction was finished the solvent is evaporated and the resulting crude was dissolved in CH2Cl2 and washed with water. The organic phase was evaporated to dryness in vacuo and the residue purified by silica gel column chromatography using as eluent AcOEt/Heptane in gradient. NMR (CDCl3): delta ppm 7.9 (d, 1H); 6.52 (d, 1H); 1.43 (s, 18 H)

The chemical industry reduces the impact on the environment during synthesis 3993-78-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; NOSCIRA, S.A.; Medina Padilla, Miguel; Dominguez Correa, Juan Manuel; Fuertes Huerta, Ana; Palomo Nicolau, Francisco; Lopez Ogalla, Javier; Herrero Santos, Susana; Alonso Cascon, Mercedes; Alonso Gordillo, Diana; Rubio Arrieta, Laura; EP2647634; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3993-78-0, name is 2-Amino-4-chloropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 2-Amino-4-chloropyrimidine

5-Methoxy-1H-pyrrolo[3,2-b]pyridine (201-20) (200 mg, 1.35 mmol, 1 eq), cesium carbonate (877.5 mg, 2.7 mmol, 2 eq) and 4-chloropyrimidin-2-amine (203-20) (261 mg, 2.025 mmol, 1.5 eq) were mixed in N-methylpyrrolidone (5 mL). The mixture was heated to 150C and stirred to react for 2 hours. After the reaction was completed, the temperature was lowered to room temperature, and the reaction mixture was quenched with water, filtered and the residue was washed with water, dried in vacuum to give a gray solid (300 mg, yield: 92.13%). LCMS (ESI): m/z 242[M + H]+.

With the rapid development of chemical substances, we look forward to future research findings about 3993-78-0.

Reference:
Patent; Guangzhou Bebetter Medicine Technology Co., Ltd.; CAI, Xiong; QIAN, Changgeng; WENG, Yunwo; LIU, Bin; WANG, Yanyan; LIN, Mingsheng; LI, Junqi; QING, Yuanhui; YOU, Huajin; ZHOU, Shiqing; XUE, Weicai; (76 pag.)EP3345900; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 3993-78-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3993-78-0, name is 2-Amino-4-chloropyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

A microwave vial was charged with 2-amino-4-chloropyrimidine (2.0 g, 15.4 mmol), and pyrrolidine (10 mL) was added. The vial was sealed, and heated in the microwave at 150 C for 1 h. After cooling, the reaction was diluted with methanol (30 mL), and silica (15 g) was added. All solvents were removed in vacuo, and the remaining silica slurry loaded on a 40.0 g silica column. Elution with a 0% to 10% methanol in dichloromethane gradient yielded 4-(pyrrolidin-1-yl)pyrimidin-2-amine (1.70 g, 67% yield). MS (ESI) calcd for C8H14N4: 164.11

According to the analysis of related databases, 3993-78-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SIRTRIS PHARMACEUTICALS, INC.; CASAUBON, Rebecca, L.; NARAYAN, Radha; OALMANN, Christopher; VU, Chi, B.; WO2013/59587; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Chemistry is an experimental science, Product Details of 3993-78-0, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 3993-78-0, Name is 2-Amino-4-chloropyrimidine, molecular formula is C4H4ClN3, belongs to pyrimidines compound. In a document, author is Fathi, Ahlam M..

Characteristics of multidentate schiff base ligand and its complexes using cyclic voltammetry, fluorescence, antimicrobial behavior and DFT-calculations

The electrochemical behavior of a series of the metal complexes [Fe(III), Ni(II), Ru(III),Pd(II) and Hf(IV)]derived from the Schiff base ligand(E)-5-((phenyl(-pyridin-2-yl) methylene) amino) pyrimidine-2,4(1H, 3H)-dione(H2L) which was previously prepared from condensation of 5-aminouracil and 2-benzoylpyridine was studied by using cyclic voltammetric technique. The Schiff base ligand H2L and its metal complexes exhibited quasi- reversible oxidation- reduction with three electron transfer and it was suggested that their reactions on the platinum surface electrode are not purely diffusion controlled but also under adsorption control. The redox reactive sites of the H2L and its complexes were located via the geometry optimization and frequency calculations using density functional theory (DFT) at the B3LYP/LanL2DZ level of theory. In addition, the Schiff base ligand and its metal complexes exhibit fluorescent properties. The antimicrobial activity of the Schiff base ligand H2L and its metal complexes was tested against Gram-positive bacteria (Staphylococcus aureus and Bacillus cereus(,Gram-negative bacteria (E. coli and Pseudomonas aeruginosa) and fungal strain (Aspergillus niger) by using agar well-diffusion method. The microbial testes of the ligand (H2L) and its metal complexes exhibited good inhibition efficiency to prevent growth of bacteria. (c) 2020 Elsevier B.V. All rights reserved.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 3993-78-0, in my other articles. Product Details of 3993-78-0.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

In an article, author is Behera, Prafulla Kumar, once mentioned the application of 3993-78-0, Quality Control of 2-Amino-4-chloropyrimidine, Name is 2-Amino-4-chloropyrimidine, molecular formula is C4H4ClN3, molecular weight is 129.55, MDL number is MFCD00038021, category is pyrimidines. Now introduce a scientific discovery about this category.

Gold(I) and gold(III) complexes supported by a pyrazine/pyrimidine wingtip N-heterocyclic carbene: Synthesis, structure and DFT studies

Starting from pyrazine and pyrimidine functionalized N-heterocyclic carbene (NHC) proligand 1-(2-Pyrazinyl)-3(methyl) imidazolium chloride (1.HCl), 1-(2-Pyrimidyl)-3(methyl) imidazolium chloride (2.HCl), four novel gold complexes [Au(1)Cl], (1a); [Au(1)Cl-3], (1b), [Au(2)Cl], (2a) and [Au(2)Cl-3] (2b) were synthesized and characterized using NMR spectroscopic techniques and elemental analysis. Additionally, the solid state structures of 1a & 2b were elucidated using single crystal X-ray diffraction analysis, which revealed that in 1a, the carbene nucleus and the chloride ion bound to Au(I) nearly linear having C-Au-Cl bond angle 178.84 degrees. Where as in 2b, the carbene nucleus and the chloride ion bound to the Au(III) adopts the square planar geometry surrounding Au(III). A series of DFT calculations were also performed to gain further insight into the respective structures of the complexes to relate the crystallographic parameters and electronic distribution. (C) 2020 Published by Elsevier B.V.

Interested yet? Read on for other articles about 3993-78-0, you can contact me at any time and look forward to more communication. Quality Control of 2-Amino-4-chloropyrimidine.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

In an article, author is Esteban-Parra, Gines M., once mentioned the application of 3993-78-0, Formula: C4H4ClN3, Name is 2-Amino-4-chloropyrimidine, molecular formula is C4H4ClN3, molecular weight is 129.55, MDL number is MFCD00038021, category is pyrimidines. Now introduce a scientific discovery about this category.

Anti-diabetic and anti-parasitic properties of a family of luminescent zinc coordination compounds based on the 7-amino-5-methyl-1,2,4-triazolo[1,5-alpha] pyrimidine ligand

We report on the formation of a triazolopyrimidine derivative ligand, 7-amino-5-methyl-1,2,4-triazolo[1,5-alpha] pyrimidine (7-amtp), and a new family of coordination compounds based on this ligand and zinc as metal ion, synthesized by conventional routes. These materials possess different mononuclear structures, namely [ZnCl2(7-amtp)(2)] (1), [Zn(7-amtp)(2)(H2O)(4)](NO3)(2)2(7-amtp)6H(2)O (2) and [Zn(7-amtp)(2)(H2O)(4)](SO4)1.5H(2)O (3) derived from the use of different zinc (II) salts, in such a way that the counterions govern the crystallization to a large extent. These compounds present and show variable luminescent properties based on ligand-centred charge transfers which have been deeply studied by Time Dependent Density Functional Theory (TD-DFT) calculations. When these compounds are transferred to solution, preserving complex entities as corroborated by NMR studies, they present interesting anti-diabetic and anti-parasitic capabilities, with a comparatively higher selectivity index than other previously reported triazolopyrimidine-based materials. The results derived from in vivo experiments conducted in mice also confirm their promising activity as anti-diabetic drug being capable of dropping glucose levels after oral administration. Therefore, these new materials may be considered as excellent candidates to be further investigated in the field of luminescent coordination compounds with biomedical applications.

If you are interested in 3993-78-0, you can contact me at any time and look forward to more communication. Formula: C4H4ClN3.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Reference of 3993-78-0, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 3993-78-0, Name is 2-Amino-4-chloropyrimidine, SMILES is C1=CN=C(N=C1Cl)N, belongs to pyrimidines compound. In a article, author is Savage, Jonathan C., introduce new discover of the category.

A Broccoli aptamer chimera yields a fluorescent K+ sensor spanning physiological concentrations

The RNA aptamer Broccoli accepts 2 ‘ fluorinated (2 ‘ F) pyrimidine nucleotide incorporation without perturbation of structure or fluorescence in the presence of potassium and DFHBI. However, the modification decreases Broccoli’s apparent affinity for K+ >30-fold. A chimera of Broccoli RNAs with mixed chemistries displays linear fluorescent gain spanning physiological K+ concentrations, yielding an effective RNA-based fluorescent K+ sensor.

Reference of 3993-78-0, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 3993-78-0 is helpful to your research.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 3993-78-0, Name is 2-Amino-4-chloropyrimidine, molecular formula is C4H4ClN3. In an article, author is Kim, Yeonji,once mentioned of 3993-78-0, COA of Formula: C4H4ClN3.

Design and Synthesis of 5-Aryl-substituted Phenylpyrimidine-2,4-diamine Derivatives as Novel Mer and Tyro3 Kinase Inhibitors

5-Aryl-substituted (piperdin-4-yl)pyrimidine-2,4-diamine derivatives were synthesized and their inhibitory activities were evaluated against TAM kinase (Tyro3, Axl, Mer), respectively. Detailed SAR studies on the fifth position of pyrimidine could lead to the discovery of potent and selective TAM kinase inhibitor. Compounds 6f, 7b, and 7f exhibited potent inhibitory activity and excellent selectivity toward Axl, Tyro3 and Mer kinases. Molecular docking studies corroborated that slight changes of substituents induced dramatic structural change of Met596, 623, 674 backbone carbonyl and amide in the hinge region of Axl, Tyro3, Mer, and resulted in different binding poses of 6f, 7b, and 7f, respectively. It was identified as a strong possibility to control selectivity by structural modification of phenyl substituents of pyrimidine as a new class of TAM kinase inhibitors.

Interested yet? Keep reading other articles of 3993-78-0, you can contact me at any time and look forward to more communication. COA of Formula: C4H4ClN3.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia