Category: 40230-24-8

Heterocycles. 41. Preparation of substituted 3,4-dihydro-2(1H)-pyrimidinimines and 2-aminopyrimidines from guanidine and 濞?閻?unsaturated ketones was written by Wendelin, Winfried;Harler, Anton. And the article was included in Monatshefte fuer Chemie in 1975.Related Products of 40230-24-8 This article mentions the following:

HN:C(NH2)2 reacted with RCOCR1:CHR3[R = Me, Ph3R1 = H, Me; R2 = H, Me, Ph, or R1R2 = (CH2)9] to give the unstable dihydropyrimidinimines I, which dehydrogenated to give the corresponding 2-pyrimidinamines II. The unstable I[R = Ph, R1 = H, R2 = Me; R-R2 = Me; R = Me, R1R2 = (CH2)4] were isolated as the corresponding stable 1H-2-pyrimidinium and 1H-2-quinazolinium picrates, whereas I(R = R2 = Ph, R1 = H) was isolated as its hydrochloride. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Related Products of 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Related Products of 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Preparation of heterocycles by the reaction of diaza binucleophiles with chalcones: influence of the substituent on position 2 was written by Simon, Dominique;Lafont, Olivier;Farnoux, Claude Combet;Miocque, Marcel. And the article was included in Journal of Heterocyclic Chemistry in 1985.COA of Formula: C16H13N3 This article mentions the following:

The reaction of PhCH:CRCOPh (R = Br, NET₂, OPh, Bz, SPh, NO₂, H) with R¹NHNH₂ gave various hydrazine derivatives or the pyrazoles I or pyrazolines II. Reaction with thiourea or guanidine gave the pyrimidines III and IV (R = H, OPh, SPh). In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8COA of Formula: C16H13N3).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.COA of Formula: C16H13N3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

A simple and highly efficient synthesis of novel fluorinated 4,6-disubstituted aminopyrimidines using Cd(OAc)₂ was written by Kumar, Amit;Kumari, Poonam;Bhagat, Sunita. And the article was included in Synthetic Communications in 2020.Related Products of 40230-24-8 This article mentions the following:

A highly efficient fluorination reaction of 4,6-disubstituted aminopyrimidines I (R¹ = C₆H₅, 4-ClC₆H₄, 4-BrC₆H₄, 4-FC₆H₄, 2-thienyl; R² = H, OMe, F, Cl, Br, Me; X = H) using N-Fluorobenzenesulfonimide (NFSI) has been developed, presumably proceeding via C-H bond activation. Cadmium acetate was employed as the salts, and various fluorinated 4,6-disubstituted aminopyrimidines I (X = F) have been generated in good to excellent yields. This chem. endows an economical method of valuable fluorinated 4,6-disubstituted aminopyrimidines I (X = F) through a direct C-F bond formation. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Related Products of 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Related Products of 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

One-pot synthesis and in vitro microbiological evaluation of pyrimidinyl thiazolidinones catalyzed by activated fly ash in dry media was written by Kanagarajan, V.;Gopalakrishnan, M.. And the article was included in Pharmaceutical Chemistry Journal in 2010.Recommanded Product: 40230-24-8 This article mentions the following:

Novel bioactive 2-phenyl-3-(4,6-diarylpyrimidin-2-yl)thiazolidin-4-ones were synthesized with good yields in a short reaction time by 1-pot multicomponent reaction of 2-amino-4,6-diarylpyrimidines, PhCHO, and thioglycolate under microwave irradiation in the presence of an activated fly ash catalyst in dry medium. The characterization of these compounds was performed by m.p., elemental anal., mass spectra, FT-IR, and ¹H and ¹³C NMR. In search for new leads toward potent antimicrobial agents, all the synthesized compounds were tested in vitro for their antibacterial activity against Bacillus subtilis and Micrococcus luteus and antifungal activity against Aspergillus niger, Candida albicans, Candida 6, and Candida 51, and the results were discussed. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Recommanded Product: 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Recommanded Product: 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Metal-free cascade synthesis of unsymmetrical 2-aminopyrimidines from imidazolate enaminones was written by Cui, Xue;Ma, Jianting;Zeng, Tingting;Xu, Junyu;Li, Youbin;Wang, Xuesong. And the article was included in RSC Advances in 2021.Application of 40230-24-8 This article mentions the following:

A convenient metal-free synthesis of unsym. 2-aminopyrimidines I [R¹ = cyclopropyl, Ph, 4-MeC₆H₄, etc.; R² = Ph, 4-ClC₆H₄, 4-MeOC₆H₄, etc.] from imidazolate enaminones had been developed. In this procedure, various structural 2-aminopyrimidines I, as well as 4,5-dihydroisoxazol-5-ols and pyrazoles were synthesized in moderate to excellent yields. A plausible mechanism was also proposed for the cascade reaction. This method represented an effective strategy toward the synthesis of unsym. 2-aminopyrimidines I. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Application of 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Application of 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthesis and in vitro microbiological evaluation of an array of biolabile 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides was written by Kanagarajan, V.;Thanusu, J.;Gopalakrishnan, M.. And the article was included in European Journal of Medicinal Chemistry in 2010.Formula: C16H13N3 This article mentions the following:

Biolabile 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides I (R¹ = H, F, Me; R² = H, F, MeO) were synthesized and evaluated for their in vitro antibacterial and antifungal activities. The min. inhibitory concentration tested against the same set of bacterial and fungal strains showed that I (R¹ = F, R² = H) against 閻?Hemolytic streptococcus and Klebsiella pneumoniae and I (R¹ = R² = F) against Escherichia coli and Pseudomonas had excellent antibacterial activity. Compounds I (R¹ = F, R² = H, MeO) showed inhibition against Aspergillus flavus, I (R¹ = Me, R² = F) against Microsporum gypseum, I (R¹ = F, R² = MeO) against Mucor, and compounds I (R¹ = Me, R² = MeO; R¹ = R² = F) against Rhizopus. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Formula: C16H13N3).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Formula: C16H13N3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Ionic Liquid-Coated Nanoparticles (CaO@SiO₂@BAIL): A Bi-Functional and Environmentally Benign Catalyst for Green Synthesis of Pyridine, Pyrimidine, and Pyrazoline Derivatives was written by Sameri, Fatemeh;Bodaghifard, Mohammad Ali;Mobinikhaledi, Akbar. And the article was included in Polycyclic Aromatic Compounds in 2022.Name: 4,6-Diphenylpyrimidin-2-amine This article mentions the following:

A novel ionic liquid-coated nanomaterials (CaO@SiO₂@BAIL) was successfully synthesized by anchoring the 1-(3-(trimethoxysilyl)propyl)-1,3,5,7-tetraazaadamantan-1-ium chlorozincate (II) bi-functional ionic liquid (BAIL) onto the surface of silica-coated CaO nanoparticles. The structure of catalyst was characterized using various anal. techniques such as Fourier-transform IR spectroscopy (FT-IR), X-ray powder diffraction (XRD), scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDS), WDS map scan, thermogravimetric (TGA), and inductively-coupled plasma-mass spectrometry (ICP-MS). The performances of prepared hybrid nanomaterial (CaO@SiO₂@BAIL) as a catalyst were evaluated for the efficient synthesis of the pharmaceutically valuable heterocyclic compounds A variety of pyridine, pyrimidine, and pyrazoline derivatives were synthesized in the presence of CaO@SiO₂@BAIL within green conditions. The presented method has several advantages such as high yields, low reaction times, and easy preparation of the catalyst. The bi-functional heterogeneous nanocatalyst can be reused at least six times without considerable loss of its catalytic activity. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Name: 4,6-Diphenylpyrimidin-2-amine).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Name: 4,6-Diphenylpyrimidin-2-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Hyperactive magnetically separable nano-sized MgFe₂O₄ catalyst for the synthesis of several five- and six-membered heterocycles was written by Bansal, Shobha;Kumar, Yogendra;Das, Dipak Kumar;Singh, Prabal Pratap. And the article was included in Chemistry & Chemical Technology in 2019.Recommanded Product: 40230-24-8 This article mentions the following:

MgFe₂O₄ nanoparticle ferrites were synthesized by combustion technique using pure ferric nitrate and magnesium nitratecarbonate. The magnetically separable MgFe₂O₄ MNP’s were found to be hyper active catalyst for the synthesis of a wide range of biol. active five and six-membered heterocyclic moieties at refluxing conditions. Reaction times were lowest in comparison to all reported in literature with excellent yields. Strong electron pull of Fe³⁺ was responsible for its hyper activity, which was substantiated by substitution of Fe³⁺ by other trivalent metal ions. Mg²⁺ contain a unique role because replacement of Mg²⁺ has poor catalytic activity. The developed protocol was efficiently utilized for the synthesis of a series of substituted mono/bis pyrimidines, pyrimidin-2-ol, pyrimidin-2-thiol, pyrazoles and isoxazoles by condensing monochalcones/1,4-bischalcones with various bis-nucleophiles in the presence of catalytic amount of heterogenous magnetic MgFe₂O₄ nanoparticles. The structure of these synthesized compounds was determined by FTIR, ¹H, ¹³C and mass spectra. The catalyst was removed easily from reaction mixture by using a simple external magnet. Nanoparticles of ferrite were recovered and reused with no appreciable change in the activity even after the five runs. Nanoparticles were characterized by XRD, TEM and IR spectroscopy. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Recommanded Product: 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Recommanded Product: 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthesis of pyrimidine derivatives by the reaction of pyrylium salts with guanidine and compounds of its series was written by Zvezdina, E. A.;Zhdanova, M. P.;Dorofeenko, G. N.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1980.Application In Synthesis of 4,6-Diphenylpyrimidin-2-amine This article mentions the following:

Treatment of pyrylium salts I (R = Ph, p-MeOC₆H₄, p-O₂NC₆H₄; R¹ = Ph) with H₂NC(:NH)NH₂.HBr gave 35-63% pyrimidinylpyridinium salts II. Pyrimidinum salts III (R = Ph, p-MeOC₆H₄) were obtained in 43 and 69% yield, resp. by reaction of I with methylguanidine nitrate. I and sulfanylguanidine gave pyridinium salts IV (R = R¹ = Ph, Me). 1,2,4,6-Tetraphenylpyridinium perchlorate was obtained in 25% yield by reaction of I with PhNHC(:NPh)NH₂. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Application In Synthesis of 4,6-Diphenylpyrimidin-2-amine).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Application In Synthesis of 4,6-Diphenylpyrimidin-2-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthesis and evaluation of 2-(2,6-dihalophenyl)-3-pyrimidinyl-1,3-thiazolidin-4-one analogues as anti-HIV-1 agents was written by Rawal, Ravindra K.;Tripathi, Rajkamal;Katti, S. B.;Pannecouque, Christophe;De Clercq, Erik. And the article was included in Bioorganic & Medicinal Chemistry in 2007.Application In Synthesis of 4,6-Diphenylpyrimidin-2-amine This article mentions the following:

A series of 2-(2,6-dihalophenyl)-3-(substituted pyrimidinyl)-1,3-thiazolidin-4-ones were designed on the prediction of quant. structure-activity relationship (QSAR) studies, synthesized, and evaluated as HIV-1 reverse transcriptase inhibitors. Our attempts in correlating the identified mol. surface features related properties for modeling the HIV-1 RT inhibitory activity resulted in some statistically significant QSAR models with good predictive ability. The results showed that compounds 4m (I, R₁ = Cl) and 4n (I, R₁ = F) were highly active in inhibiting HIV-1 replication with EC₅₀ values in the range of 22-28 nM in MT-4 as well as in CEM cells with selectivity indexes of >10,000. The derived models collectively suggest that the compounds should be compact without bulky substitution on its peripheries for better HIV-1 RT inhibitory activity. These models also indicate a preference for hydrophobic compounds to obtain good HIV-1 RT inhibitory activity. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Application In Synthesis of 4,6-Diphenylpyrimidin-2-amine).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Application In Synthesis of 4,6-Diphenylpyrimidin-2-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia