Butta, Ragavendra et al. published their research in Journal of Heterocyclic Chemistry in 2017 | CAS: 40230-24-8

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Quality Control of 4,6-Diphenylpyrimidin-2-amine

Synthesis and Antimicrobial Activity of Azolyl Pyrimidines was written by Butta, Ragavendra;Donthamsetty V, Sowmya;Adivireddy, Padmaja;Venkatapuram, Padmavathi. And the article was included in Journal of Heterocyclic Chemistry in 2017.Quality Control of 4,6-Diphenylpyrimidin-2-amine This article mentions the following:

A new class of azolyl pyrimidines I (X = O, S, NH; R = C6H5, 4-H3CC6H4, 4-ClC6H4, 4-BrC6H4, 4-O2NC6H4) linked by diamino sulfone moiety was prepared and their antimicrobial activity was studied. Chloro-substituted and nitro-substituted thiazolyl pyrimidines I (X = S; R = 4-ClC6H4 and 4-O2NC6H4) showed excellent antibacterial activity against Bacillus subtilis, while imidazolyl pyrimidines I (X = NH; R = 4-ClC6H4 and 4-O2NC6H4) exhibited promising antifungal activity against Aspergillus niger. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Quality Control of 4,6-Diphenylpyrimidin-2-amine).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Quality Control of 4,6-Diphenylpyrimidin-2-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Zanatta, Nilo et al. published their research in Journal of Heterocyclic Chemistry in 2008 | CAS: 40230-24-8

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Related Products of 40230-24-8

Synthesis and characterization of new trifluoromethyl substituted 3-ethoxycarbonyl- and 3-pyrimidin-2-yl-(1,2,3)-oxathiazinane-S-oxides was written by Zanatta, Nilo;Borchhardt, Deise M.;Flores, Darlene C.;Coelho, Helena S.;Marchi, Tiago M.;Flores, Alex F. C.;Bonacorso, Helio G.;Martins, Marcos A. P.. And the article was included in Journal of Heterocyclic Chemistry in 2008.Related Products of 40230-24-8 This article mentions the following:

This paper describes the synthesis and characterization of a new series of 4-substituted 3-ethoxycarbonyl- and 3-(4,6-diphenylpyrimidin-2-yl)-6-trifluoromethyl-(1,2,3)oxathiazinane S-oxides by cyclization of 4,4,4-trifluoro-3-hydroxybutylcarbamates and 4-(4,6-diphenylpyrimidin-2-ylamino)-1,1,1-trifluorobutan-2-ols, resp., with SOCl2. The anal. of the NMR data allowed us to define important features of the mol. structure. Significant chem. and structural differences were observed between the trifluoromethylated oxathiazinanes obtained in this work from other analogous compounds reported in the literature. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Related Products of 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Related Products of 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Meenakshisundaram, S. P. et al. published their research in Catalysis Communications in 2007 | CAS: 40230-24-8

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.SDS of cas: 40230-24-8

Oxalic acid catalysed chromium(VI) oxidation of some 2-amino-4,6-diarylpyrimidines was written by Meenakshisundaram, S. P.;Gopalakrishnan, M.;Nagarajan, S.;Sarathi, N.. And the article was included in Catalysis Communications in 2007.SDS of cas: 40230-24-8 This article mentions the following:

Some 2-amino-4,6-diarylpyrimidines (APM), synthesized from chalcones and guanidine hydrochloride in presence of alkali by microwave irradiation in solvent-free conditions, were subjected to oxidation with chromium(VI)-oxalic acid complex (Cr(VI)-Oxa) in highly acidic solutions Oxalic acid (Oxa) offers the reaction a more favorable pathway and in the absence of oxalic acid the reaction is sluggish. The depletion of chromium(VI) shows a complicated kinetics involving a fast reaction to about 35% consumption followed by a slow one. Low dielec. constant of the medium facilitates the reaction. The investigations with 2-amino-6-(4-nitrophenyl)- 4-phenylpyrimidine and 2-amino-6-(4-methoxyphenyl)-4-phenylpyrimidine reveal that, irresp. of the nature of the substituents, the rates are higher than for the parent. APM is catalytically converted to the unusual product 3-hydroxy-1,3-diphenyl-propan-1-one. Consideration of the kinetic behaviors under different exptl. conditions and the product assignment provide valuable mechanistic insight into the system studied. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8SDS of cas: 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.SDS of cas: 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Brown, D. J. et al. published their research in Australian Journal of Chemistry in 1973 | CAS: 40230-24-8

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Computed Properties of C16H13N3

Pyrimidine reactions. XXIV. Dehalogenation of 2-halopyrimidines by hydriodic acid was written by Brown, D. J.;Waring, P.. And the article was included in Australian Journal of Chemistry in 1973.Computed Properties of C16H13N3 This article mentions the following:

2-Halopyrimidines underwent dehalogenation conveniently on treatment with hot HI to give the pyrimidines (I; R1 = H, R = R2 = Me, Ph; R = R2 = H, R1 = Me; R1 = R2 = H, R = Me). Unsubstituted pyrimidine was obtained similarly from its 2-chloro-, 2-bromo, or 2-iodo derivative, the last was made in a pure state for the first time. 4-Chloro-2,6-dimethylpyrimidine underwent hydrolysis in hot HI, and transhalogenation to give its 4-iodo analog at lower temperatures; both 2-chloro-4-methoxypyrimidine and 5-chlorouracil gave uracil with hot HI and 4-chloro-2,6-dimethoxypyrimidine gave 6-iodouracil under similar conditions. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Computed Properties of C16H13N3).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Computed Properties of C16H13N3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Kanagarajan, V. et al. published their research in Pharmaceutical Chemistry Journal in 2012 | CAS: 40230-24-8

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Computed Properties of C16H13N3

Pyrimidino piperazinyl acetamides: innovative class of hybrid acetamide drugs as potent antimicrobial and antimycobacterial agents was written by Kanagarajan, V.;Gopalakrishnan, M.. And the article was included in Pharmaceutical Chemistry Journal in 2012.Computed Properties of C16H13N3 This article mentions the following:

New 2-(4-methylpiperazin-1-yl)-N-(4,6-diarylpyrimidin-2-yl)acetamides (34-42) have been synthesized and tested for their in vitro antimicrobial and antimycobacterial properties. Compounds 34, 39 against S. aureus, 39 against 閻?hemolytic Streptococcus, 42 against V. cholerae, 40-42 against E. coli, 38, 39 against K. pneumoniae, and 37-41 against P. aeruginosa showed excellent antibacterial activity by inhibiting the growth of the resp. organisms at a min. inhibitory concentration of 6.25 婵炴挾鎸?mL. Noteworthy compounds 40 against A. flavus, 34 against M. indicus, 40, 42 against R. arrhizus and M. gypseum also exhibited excellent antifungal activity by inhibiting the growth of these microorganisms, at a min. inhibitory concentration of 6.25 婵炴挾鎸?mL. Moreover, compounds 36, 38, and 40-42 showed promising antitubercular activity by inhibiting the growth of M. tuberculosis H 37 Rv and clin. isolated isoniazid-resistant M. tuberculosis strains. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Computed Properties of C16H13N3).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Computed Properties of C16H13N3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Mudaliar, Sulochana S. et al. published their research in ChemistrySelect in 2017 | CAS: 40230-24-8

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.HPLC of Formula: 40230-24-8

An Efficient Synthetic Strategy for sp3(C)-N Amination on 4-thiazolidinone with Primary Heteroaryl Amines was written by Mudaliar, Sulochana S.;Shaikh, Mohammedumar M.;Chikhalia, Kishor H.. And the article was included in ChemistrySelect in 2017.HPLC of Formula: 40230-24-8 This article mentions the following:

An efficient sp3(C)-N amination reaction between 4-thiazolidinone and primary heteroaryl amine has been developed under C-H functionalization. Cross-coupling reaction between non-prefunctionalized slightly more acidic sp3 C-H bond of 4-thiazolidinones and different heteroaryl amines involving one-pot synthetic strategy, single step reaction as well as aerial oxidation make this amination more effective than existing methods for the construction of sp3(C)-N bond. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8HPLC of Formula: 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.HPLC of Formula: 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Kumar, Bhupinder et al. published their research in Bioorganic Chemistry in 2018 | CAS: 40230-24-8

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.HPLC of Formula: 40230-24-8

Synthesis and biological evaluation of pyrimidine bridged combretastatin derivatives as potential anticancer agents and mechanistic studies was written by Kumar, Bhupinder;Sharma, Praveen;Gupta, Vivek Prakash;Khullar, Madhu;Singh, Sandeep;Dogra, Nilambra;Kumar, Vinod. And the article was included in Bioorganic Chemistry in 2018.HPLC of Formula: 40230-24-8 This article mentions the following:

A number of pyrimidine bridged combretastatin derivatives were designed, synthesized and evaluated for anticancer activities against breast cancer (MCF-7) and lung cancer (A549) cell lines using MTT assays. Most of the synthesized compounds displayed good anticancer activity with IC50 values in low micro-molar range. Compounds I and II were found most potent in the series with IC50 values of 4.67 娓璏 & 3.38 娓璏 and 4.63 娓璏 & 3.71 娓璏 against MCF7 and A549 cancer cell lines, resp. Biol. evaluation of these compounds showed that selective cancer cell toxicity (in vitro using human lung and breast cancer cell lines) might be due to the inhibition of antioxidant enzymes instigating elevated ROS levels which triggers intrinsic apoptotic pathways. These compounds were found nontoxic to the normal human primary cells. Compound I, was found to be competitive inhibitor of colchicine and in the tubulin binding assay it showed tubulin polymerization inhibition potential comparable to colchicine. The mol. modeling studies also showed that the synthesized compounds fit well in the colchicine-binding pocket. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8HPLC of Formula: 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.HPLC of Formula: 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Glotova, T. E. et al. published their research in Russian Journal of Organic Chemistry in 2007 | CAS: 40230-24-8

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.SDS of cas: 40230-24-8

Reaction of N-(carbamimidoyl)thiourea with 1-benzoyl-2-phenylacetylene was written by Glotova, T. E.;Dvorko, M. Yu.;Albanov, A. I.;Protsuk, N. I.. And the article was included in Russian Journal of Organic Chemistry in 2007.SDS of cas: 40230-24-8 This article mentions the following:

1-Benzoyl-2-phenylacetylene reacted with N-(carbamimidoyl)thiourea H2NC(:S)NHC(:NH)NH2 in glacial acetic acid saturated with 20% HBr to give (4,6-diphenyl-2H-1,3-thiazin-2-ylidene)guanidine hydrobromide. The reaction of the same compounds in anhydrous EtOH in the presence of NaOEt led to the formation of N-(4,6-diphenylpyrimidin-2-yl)thiourea. Bis(3-oxo-1,3-diphenylprop-1-en-1-yl) sulfide and 1-benzoyl-2-ethylsulfanyl-2-phenylethylene were isolated in the reactions of 1-benzoyl-2-phenylacetylene with N-(carbamimidoyl)thiourea and N-(carbamimidoyl)-S-ethylisothiuronium bromide, resp., in anhydrous MeOH. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8SDS of cas: 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.SDS of cas: 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Saikia, Susmita et al. published their research in ChemistrySelect in 2019 | CAS: 40230-24-8

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Related Products of 40230-24-8

One-Pot Sequential Synthesis of 2-Amino-4,6-Diaryl Pyrimidines Involving SO3H-Functionalized Piperazinium-Based Dicationic Ionic Liquids as Homogeneous Catalysts was written by Saikia, Susmita;Borah, Ruli. And the article was included in ChemistrySelect in 2019.Related Products of 40230-24-8 This article mentions the following:

A new series of -SO3H functionalized dicationic ionic liquids based on N,N,N’,N’-tetrasulfopiperazinium cation [TSPi]+ and various anions [X] (X = Cl, CF3SO3, TsO) was synthesized. Bronsted acidity of these ionic liquids was determined by Hammett plot using UV-Visible absorbance spectra. Further, they were examined as acidic catalysts for one-pot preparation of 2-amino-4,6-diarylpyrimidines I [R = H, 2-HO, 4-Cl, 2,4-Cl2, etc.] through Biginelli-like reaction of acetophenone, benzaldehydes and urea followed by a condensation-aromatization reaction with phenylhydrazine under solvent-free grinding method. The most acidic catalyst, [TSPi][CF3SO3]2, offered good to satisfactory yield within 15-25 mins reaction time. Easy recyclability and simple and mild reaction conditions represented the advantages of this method. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Related Products of 40230-24-8).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Related Products of 40230-24-8

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Cousins, David L. et al. published their research in Angewandte Chemie, International Edition in 2021 | CAS: 40230-24-8

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Category: pyrimidines

Pyrimidin-6-yl Trifluoroborate Salts as Versatile Templates for Heterocycle Synthesis was written by Cousins, David L.;Fricero, Prisca;Kopf, Kenji P. M.;McColl, Elliot J.;Czechtizky, Werngard;Lim, Yee Hwee;Harrity, Joseph P. A.. And the article was included in Angewandte Chemie, International Edition in 2021.Category: pyrimidines This article mentions the following:

We report a novel and general method to access a highly understudied privileged scaffold – pyrimidines bearing a trifluoroborate at C4 (e.g., I) and highlight the broad utility of these intermediates in a rich array of downstream functionalization reactions. This chem. is underpinned by the unique features of the trifluoroborate group; its robustness provides an opportunity to carry out chemoselective reactions at other positions on the pyrimidine while providing a pathway for elaboration at the C-B bond when suitably activated. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Category: pyrimidines).

4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia